University of Oulu

Metsämarttila, E., Rodilla, E., Jokelainen, J., Herrala, S., Leppäluoto, J., Keinänen-Kiukaanniemi, S., Herzig, K. (2018) Effect of physical activity on pulse wave velocity in elderly subjects with normal glucose, prediabetes or Type 2 Diabetes. Scientific Reports, 8 (1), 8045. doi:10.1038/s41598-018-25755-4

Effect of physical activity on pulse wave velocity in elderly subjects with normal glucose, prediabetes or Type 2 Diabetes

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Author: Metsämarttila, Erja1; Rodilla, Enrique2,3; Jokelainen, Jari4;
Organizations: 1Research Unit of Biomedicine, and Biocenter of Oulu, Oulu University
2Hypertension Clinic, Internal Medicine, Hospital de Sagunto
3Universidad Cardenal Herrera-CEU, CEU Universities
4Center for Life Course Epidemiology and Systems Medicine, Faculty of Medicine, University of Oulu
5Oulu University Hospital, Unit of General Practice, and Health Center of Oulu
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.5 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2018081033597
Language: English
Published: Springer Nature, 2018
Publish Date: 2018-08-10
Description:

Abstract

Carotid-femoral pulse wave velocity ((cf)PWV) is a measure of arterial stiffness, predicting cardiovascular disease. We hypothesized that the amount of physical activity (PA) is correlated with reduced arterial stiffness in Type 2 diabetic (T2D) subjects. 570 subjects from the 1945 Oulu birth cohort were included in the analysis. (cf)PWV was determined by a non-invasive applanation tonometry. Oral glucose tolerance test was performed and LDL and HDL cholesterol analyzed. PA was registered daily with a wrist-worn acceleration meter for two weeks. (cf)PWV values in subjects with impaired glucose metabolism (IGM) and T2D were higher than in normal glycemic subjects (P < 0.001). PA, fasting and 2 h glucose and HbA1c correlated significantly with (cf)PWV, but HDL or LDL cholesterol did not. The 2 h glucose, heart rate and alcohol consumption in T2D subjects had independent effects on (cf)PWV in multiple regression analysis. T2D and IGM were significantly associated to (cf)PWV. Interestingly, lipids did not have an additional effect on (cf)PWV. Subjects walking more than 10 000 steps/day had 0.2 m/s lower (cf)PWV than those walking less than 6000 steps/day. Presence of T2D, elevated heart rate and alcohol consumption in males were associated with increased aortic stiffening in elderly subjects.

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Series: Scientific reports
ISSN: 2045-2322
ISSN-E: 2045-2322
ISSN-L: 2045-2322
Volume: 8
Issue: 1
Article number: 8045
DOI: 10.1038/s41598-018-25755-4
OADOI: https://oadoi.org/10.1038/s41598-018-25755-4
Type of Publication: A1 Journal article – refereed
Field of Science: 3141 Health care science
3121 Internal medicine
Subjects:
Funding: The study was funded by University of Oulu Hospital Fund.
Copyright information: © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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