University of Oulu

Akbaraly, T., Würtz, P., Singh-Manoux, A., Shipley, M., Haapakoski, R., Lehto, M., Desrumaux, C., Kähönen, M., Lehtimäki, T., Mikkilä, V., Hingorani, A., Humphries, S., Kangas, A., Soininen, P., Raitakari, O., Ala-Korpela, M., Kivimäki, M. (2018) Association of circulating metabolites with healthy diet and risk of cardiovascular disease: analysis of two cohort studies. Scientific Reports, 8 (1), 8620. doi:10.1038/s41598-018-26441-1

Association of circulating metabolites with healthy diet and risk of cardiovascular disease : analysis of two cohort studies

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Author: Akbaraly, Tasnime1,2,3,4,5; Würtz, Peter6; Singh-Manoux, Archana2,7;
Organizations: 1Inserm U 1198
2Department of Epidemiology and Public Health, London, University College London
3Department of Psychiatry & Autism Resources Centre, Hospital and University Research Center of Montpellier - CHRU
4University Montpellier
6Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu
7INSERM, U1018, Centre for Research in Epidemiology and Population Health, Hôpital Paul Brousse
8Department of Clinical Physiology, University of Tampere School of Medicine and Tampere University Hospital
9Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine
10Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku
11Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Institute of Cardiovascular Sciences, University College London
12NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland
13Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital
14Medical Research Council Integrative Epidemiology Unit at the University of Bristol
15Population Health Science, Bristol Medical School, University of Bristol
16Systems Epidemiology, Baker Heart and Diabetes Institute
17Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, The Alfred Hospital, Monash University
18Clinicum, Faculty of Medicine, University of Helsinki
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 3 MB)
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Language: English
Published: Springer Nature, 2018
Publish Date: 2018-08-16


Diet may modify metabolomic profiles towards higher or lower cardiovascular disease (CVD) risk. We aimed to identify metabolite profiles associated with high adherence to dietary recommendations — the Alternative Healthy Eating Index (AHEI) — and the extent to which metabolites associated with AHEI also predict incident CVD. Relations between AHEI score and 80 circulating lipids and metabolites, quantified by nuclear magnetic resonance metabolomics, were examined using linear regression models in the Whitehall II study (n = 4824, 55.9 ± 6.1 years, 28.0% women) and were replicated in the Cardiovascular Risk in Young Finns Study (n = 1716, 37.7 ± 5.0 years, 56.3% women). We used Cox models to study associations between metabolites and incident CVD over the 15.8-year follow-up in the Whitehall II study. After adjustment for confounders, higher AHEI score (indicating healthier diet) was associated with higher degree of unsaturation of fatty acids (FA) and higher ratios of polyunsaturated FA, omega-3 and docosahexaenoic acid relative to total FA in both Whitehall II and Young Finns studies. A concordance of associations of metabolites with higher AHEI score and lower CVD risk was observed in Whitehall II. Adherence to healthy diet seems to be associated with specific FA that reduce risk of CVD.

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Series: Scientific reports
ISSN: 2045-2322
ISSN-E: 2045-2322
ISSN-L: 2045-2322
Volume: 8
Issue: 1
Article number: 8620
DOI: 10.1038/s41598-018-26441-1
Type of Publication: A1 Journal article – refereed
Field of Science: 3142 Public health care science, environmental and occupational health
3141 Health care science
3121 General medicine, internal medicine and other clinical medicine
Funding: We thank all of the participating civil service departments and their welfare, personnel, and establishment officers; the British Occupational Health and Safety Agency; the British Council of Civil Service Unions; all participating civil servants in the Whitehall II study; and all members of the Whitehall II study team. The Whitehall II Study team comprises research scientists, statisticians, study coordinators, nurses, data managers, administrative assistants and data entry staff, who make the study possible. The Whitehall II study has been supported by grants from the UK Medical Research Council (K013351 and MR/R024227/1); the British Heart Foundation (PG/11/63/29011 and RG/13/2/30098); the British Health and Safety Executive; the British Department of Health; the National Heart, Lung, and Blood Institute (R01HL036310); the National Institute on Aging, National Institute of Health (R01AG013196, R01 AG034454); the Economic and Social Research Council (ES/J023299/1). The Young Finns Study has been financially supported by the Academy of Finland: grants 286284 (T.L.), 134309, 126925, 121584, 124282, 129378 (Salve), 117787 (Gendi), and 41071 (Skidi); the Social Insurance Institution of Finland; Kuopio, Tampere and Turku University Hospital Medical Funds (grant X51001 for T.L.); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation of Cardiovascular Research; Finnish Cultural Foundation; Tampere Tuberculosis Foundation (T.L.); Emil Aaltonen Foundation (T.L.); Yrjö Jahnsson Foundation (T.L.). and Signe ja Ane Gyllenberg’s Foundation (T.L). Tasnime Akbaraly is supported by the Medical Research Council (K013351). Peter Würtz is supported by the Novo Nordisk Foundation and the Academy of Finland (294834). Martin Shipley is supported by the British Heart Foundation. Steven Humphries was supported by the BHF (PG08/008) and the National Institute for Health Research University College London Hospitals Biomedical Research Centre. Rita Haapakoski was supported by the European Commission LIFEPATH project (Horizon 2020 grant 633666). Mika Ala-Korpela has been supported by the Sigrid Juselius Foundation and the Strategic Research Funding from the University of Oulu, Finland. He works in a unit that is supported by the University of Bristol and UK Medical Research Council (MC_UU_12013/1). The Baker Institute is supported in part by the Victorian Government’s Operational Infrastructure Support Program. Mika Kivimaki is supported by the Medical Research Council (K013351 and MR/R024227/1), UK, NordForsk, the Nordic Programme on Health and Welfare, the Academy of Finland (311492) and a Helsinki Institute of Life Science fellowship. The funding organization or sponsor had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Academy of Finland Grant Number: 286284
Detailed Information: 286284 (Academy of Finland Funding decision)
134309 (Academy of Finland Funding decision)
126925 (Academy of Finland Funding decision)
121584 (Academy of Finland Funding decision)
124282 (Academy of Finland Funding decision)
129378 (Academy of Finland Funding decision)
117787 (Academy of Finland Funding decision)
41071 (Academy of Finland Funding decision)
294834 (Academy of Finland Funding decision)
311492 (Academy of Finland Funding decision)
Dataset Reference: Electronic supplementary material
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