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Dynamics of plasma lipidome in progression to islet autoimmunity and type 1 diabetes : type 1 diabetes prediction and prevention study (DIPP) |
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| Author: | Lamichhane, Santosh1; Ahonen, Linda2; Sparholt Dyrlund, Thomas2; |
| Organizations: |
1Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, 20520, Finland 2Steno Diabetes Center Copenhagen, 2820, Gentofte, Denmark 3Children’s Hospital, University of Helsinki and Helsinki University Hospital, 00290, Helsinki, Finland
4Research Program Unit, Diabetes and Obesity, University of Helsinki, 00290, Helsinki, Finland
5Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland 6Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland 7Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland 8Clinical Microbiology, Turku University Hospital, Turku, Finland 9Institute of Biomedicine, Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland 10Department of Pediatrics, Turku University Hospital, Turku, Finland 11Department of Paediatrics, PEDEGO Research Unit, Medical Research Centre, University of Oulu, Oulu, Finland 12Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland 13Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden 14Department of Chemistry, Örebro University, 702 81, Örebro, Sweden 15Tampere Center for Child Health Research, Tampere University Hospital, Tampere, Finland 16Folkhälsan Research Center, Helsinki, Finland 17School of Medical Sciences, Örebro University, 702 81, Örebro, Sweden |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 3 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2018091735930 |
| Language: | English |
| Published: |
Springer Nature,
2018
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| Publish Date: | 2018-09-17 |
| Description: |
AbstractType 1 diabetes (T1D) is one of the most prevalent autoimmune diseases among children in Western countries. Earlier metabolomics studies suggest that T1D is preceded by dysregulation of lipid metabolism. Here we used a lipidomics approach to analyze molecular lipids in a prospective series of 428 plasma samples from 40 children who progressed to T1D (PT1D), 40 children who developed at least a single islet autoantibody but did not progress to T1D during the follow-up (P1Ab) and 40 matched controls (CTR). Sphingomyelins were found to be persistently downregulated in PT1D when compared to the P1Ab and CTR groups. Triacylglycerols and phosphatidylcholines were mainly downregulated in PT1D as compared to P1Ab at the age of 3 months. Our study suggests that distinct lipidomic signatures characterize children who progressed to islet autoimmunity or overt T1D, which may be helpful in the identification of at-risk children before the initiation of autoimmunity. see all
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| Series: |
Scientific reports |
| ISSN: | 2045-2322 |
| ISSN-E: | 2045-2322 |
| ISSN-L: | 2045-2322 |
| Volume: | 8 |
| Article number: | 10635 |
| DOI: | 10.1038/s41598-018-28907-8 |
| OADOI: | https://oadoi.org/10.1038/s41598-018-28907-8 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3121 General medicine, internal medicine and other clinical medicine |
| Subjects: | |
| Funding: |
This work was supported by the JDRF grants 4-1998-274, 4-1999-731 4-2001-435 and special research funds for Oulu, Tampere and Turku University Hospitals in Finland. This work was supported by the Juvenile Diabetes Research Foundation (2-SRA-2014-159-Q-R to M.O.) and the Academy of Finland (Centre of Excellence in Molecular Systems Immunology and Physiology Research – SyMMyS, Decision No. 250114, to M.O. and M.K.). |
| Copyright information: |
© The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
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https://creativecommons.org/licenses/by/4.0/ |