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Impaired glucose metabolism is associated with tooth loss in middle-aged adults : the Northern Finland Birth Cohort Study 1966 |
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| Author: | Similä, Toni1,2; Auvinen, Juha2,3; Puukka, Katri2,4; |
| Organizations: |
1Research Unit of Oral Health Sciences, Faculty of Medicine, University of Oulu, P.O. Box 5000, Oulu 90014, Finland 2Medical Research Center Oulu, Oulu University Hospital, P.O. Box 5000, Oulu 90029, Finland 3Center for Life Course Health Research, University of Oulu, P.O. Box 5000, Oulu 90014, Finland
4NordLab Oulu, Oulu University Hospital, P.O. Box 500, Oulu 90029, Finland
5Health Center of Oulu, Oulu, Finland |
| Format: | article |
| Version: | accepted version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.7 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2018100137050 |
| Language: | English |
| Published: |
Elsevier,
2018
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| Publish Date: | 2019-05-30 |
| Description: |
AbstractAims: We investigated the association of impaired glucose metabolism with tooth loss in adults in the Northern Finland Birth Cohort Study 1966 (NFBC1966). Methods: We examined 4394 participants from the 46-year follow-up of the NFBC1966. Self-reported number of teeth as well as insulin and glucose values, taken during a standard oral glucose tolerance test (OGTT), served as the primary study variables. A multinomial logistic regression model served to analyse (unadjusted, smoking-adjusted and fully adjusted) the association between number of teeth (0–24, 25–27, 28–32) and glucose metabolism in women and men. Results: Among women, type 2 diabetes — whether previously known or detected during screening — pointed to a higher likelihood of 0–24 teeth (fully adjusted OR = 2.99, 95%CI = 1.54–5.80) and 25–27 teeth (OR = 1.91, 95%CI = 1.18–3.08) than did normal glucose tolerance. Similarly, impaired fasting glucose and impaired glucose tolerance together indicated a higher likelihood of 0–24 teeth (OR = 1.71, 95%CI = 1.09–2.69) than did normal glucose tolerance. A similar, statistically non-significant, pattern emerged among men. Number of teeth associated with OGTT insulin and glucose curves as well as with the Matsuda index in both women and men. Conclusions: Tooth loss strongly associated with impaired glucose metabolism in middle-aged Finnish women see all
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| Series: |
Diabetes research and clinical practice |
| ISSN: | 0168-8227 |
| ISSN-E: | 1872-8227 |
| ISSN-L: | 0168-8227 |
| Volume: | 142 |
| Pages: | 110 - 119 |
| DOI: | 10.1016/j.diabres.2018.05.035 |
| OADOI: | https://oadoi.org/10.1016/j.diabres.2018.05.035 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3121 General medicine, internal medicine and other clinical medicine 313 Dentistry 3142 Public health care science, environmental and occupational health |
| Subjects: | |
| Funding: |
NFBC1966 received financial support from University of Oulu Grant no. 24000692, Oulu University Hospital Grant no. 24301140, ERDF European Regional Development Fund Grant no. 539/2010 A31592. |
| Dataset Reference: |
Data is available from the Northern Finland Birth Cohort (NFBC) for researchers who meet the criteria for accessing confidential data. Please, contact NFBC project center (NFBCprojectcenter@oulu.fi) and visit the cohort website (http://www.oulu.fi/nfbc/) for more information. |
| Copyright information: |
© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |