University of Oulu

Toni Similä, Juha Auvinen, Katri Puukka, Sirkka Keinänen-Kiukaanniemi, Jorma I. Virtanen, Impaired glucose metabolism is associated with tooth loss in middle-aged adults: The Northern Finland Birth Cohort Study 1966, Diabetes Research and Clinical Practice, Volume 142, 2018, Pages 110-119, ISSN 0168-8227, https://doi.org/10.1016/j.diabres.2018.05.035

Impaired glucose metabolism is associated with tooth loss in middle-aged adults : the Northern Finland Birth Cohort Study 1966

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Author: Similä, Toni1,2; Auvinen, Juha2,3; Puukka, Katri2,4;
Organizations: 1Research Unit of Oral Health Sciences, Faculty of Medicine, University of Oulu, P.O. Box 5000, Oulu 90014, Finland
2Medical Research Center Oulu, Oulu University Hospital, P.O. Box 5000, Oulu 90029, Finland
3Center for Life Course Health Research, University of Oulu, P.O. Box 5000, Oulu 90014, Finland
4NordLab Oulu, Oulu University Hospital, P.O. Box 500, Oulu 90029, Finland
5Health Center of Oulu, Oulu, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2018100137050
Language: English
Published: Elsevier, 2018
Publish Date: 2019-05-30
Description:

Abstract

Aims: We investigated the association of impaired glucose metabolism with tooth loss in adults in the Northern Finland Birth Cohort Study 1966 (NFBC1966).

Methods: We examined 4394 participants from the 46-year follow-up of the NFBC1966. Self-reported number of teeth as well as insulin and glucose values, taken during a standard oral glucose tolerance test (OGTT), served as the primary study variables. A multinomial logistic regression model served to analyse (unadjusted, smoking-adjusted and fully adjusted) the association between number of teeth (0–24, 25–27, 28–32) and glucose metabolism in women and men.

Results: Among women, type 2 diabetes – whether previously known or detected during screening – pointed to a higher likelihood of 0–24 teeth (fully adjusted OR = 2.99, 95%CI = 1.54–5.80) and 25–27 teeth (OR = 1.91, 95%CI = 1.18–3.08) than did normal glucose tolerance. Similarly, impaired fasting glucose and impaired glucose tolerance together indicated a higher likelihood of 0–24 teeth (OR = 1.71, 95%CI = 1.09–2.69) than did normal glucose tolerance. A similar, statistically non-significant, pattern emerged among men. Number of teeth associated with OGTT insulin and glucose curves as well as with the Matsuda index in both women and men.

Conclusions: Tooth loss strongly associated with impaired glucose metabolism in middle-aged Finnish women

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Series: Diabetes research and clinical practice
ISSN: 0168-8227
ISSN-E: 1872-8227
ISSN-L: 0168-8227
Volume: 142
Pages: 110 - 119
DOI: 10.1016/j.diabres.2018.05.035
OADOI: https://oadoi.org/10.1016/j.diabres.2018.05.035
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 Internal medicine
313 Dentistry
3142 Public health care science, environmental and occupational health
Subjects:
Funding: NFBC1966 received financial support from University of Oulu Grant no. 24000692, Oulu University Hospital Grant no. 24301140, ERDF European Regional Development Fund Grant no. 539/2010 A31592.
Dataset Reference: Data is available from the Northern Finland Birth Cohort (NFBC) for researchers who meet the criteria for accessing confidential data. Please, contact NFBC project center (NFBCprojectcenter@oulu.fi) and visit the cohort website (http://www.oulu.fi/nfbc/) for more information.
Copyright information: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
  https://creativecommons.org/licenses/by-nc-nd/4.0/