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Gender differences in thyroid function and obesity among finnish women and men : the FIN-D2D-study |
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| Author: | Saltevo, Juha1; Kautiainen, Hannu2,3,4; Mäntyselkä, Pekka4,5; |
| Organizations: |
1Department of Medicine, Central Finland Central Hospital 2Unit of Primary Health Care, Helsinki University Central Hospital 3Department of General Practice, University of Helsinki
4Primary Health Care Unit, Kuopio University Hospital
5Institute of Public Health and Clinical Nutrition, Primary Health Care, School of Medicine, University of Eastern Finland 6National Institute for Health and Welfare 7Center for Life Course Epidemiology and Systems Medicine, University of Oulu 8Unit of Primary Health Care and MRC, Oulu University Hospital 9Department of Medicine, Seinäjoki Central Hospital 10Department of Endocrinology, Helsinki University Hospital and University of Helsinki 11Pirkanmaa Hospital District 12Tampere University Hospital 13Unit of Family Practice, Central Finland Central Hospital |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.3 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2018100537587 |
| Language: | English |
| Published: |
Open Access Text,
2016
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| Publish Date: | 2018-10-05 |
| Description: |
AbstractBackground: Our aim was to study the relationship between thyroid function and body weight in a large Finnish adult population, taking into account the effect of gender, because the results of previous studies are conflicting. Methods: A random sample of 4500 Finnish subjects aged 45–74 years old was selected from the National Population Register. The participation rate was 64%. Height, weight, waist circumference, and blood pressure were measured. Medications used, current smoking, the use of alcohol, and leisure-time physical activity (LTPA) wereas queried. Thyroid values (free T4, free T3, and TSH) were measured in 1307 men and 1434 women. Subjects receiving thyroid hormone (N=92) were excluded. Results: The mean age of the subjects was 59.7 years and their mean body mass index (BMI) was 27.4 kg/m². After adjustment for age, LTPA, and current smoking, TSH showed no linearity (p=0.09) across increasing BMI; in women TSH ranged from 1.85 ± 1.15 to 2.02 ± 1.29 IU/L and in men, from 1.79 ± 1.19 to 2.04 ± 1.33 IU/L (p=0.13). FT3 -values increased from 3.85 ± 0.67 to 3.97 ± 0.59 pmol/L in women (p=0.004), but not in men, with increasing BMI. FT4 -values decreased from 13.78 ± 2.07 to 13.31 ± 1.91 pmol/L with increasing BMI in men (p<0.001 for linearity), but not in women. Conclusions: TSH values did not increase along with BMI in men and women with BMI, but FfT3 levels increased in women, and FfT4 levels decreased in men along with increasing BMI. The reasons for these gender differences need further research. see all
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| Series: |
Integrative endocrinology and metabolism |
| ISSN: | 2515-0928 |
| ISSN-L: | 2515-0928 |
| Volume: | 1 |
| Issue: | 1 |
| Pages: | 1 - 6 |
| DOI: | 10.15761/IEM.1000102 |
| OADOI: | https://oadoi.org/10.15761/IEM.1000102 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3142 Public health care science, environmental and occupational health |
| Subjects: | |
| Funding: |
FIN-D2D was supported by financing from the hospital districts of Central Finland, Pirkanmaa, Southern Ostrobothnia, North Ostrobothnia, the Finnish National Public Health Institute, the Finnish Diabetes Association, the Ministry of Social Affairs and Health in Finland, and Finland’s Slot Machine Association in cooperation with the FIN-D2D Study Group. |
| Copyright information: |
© 2016 Saltevo J. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |