University of Oulu

K. Murtoniemi, T. Vahlberg, E. Hämäläinen, E. Kajantie, A.K. Pesonen, K. Räikkönen, P. Taipale, P.M. Villa, H. Laivuori, The effect of low-dose aspirin on serum placental growth factor levels in a high-risk PREDO cohort, Pregnancy Hypertension, Volume 13, 2018, Pages 51-57, ISSN 2210-7789, https://doi.org/10.1016/j.preghy.2018.04.003

The effect of low-dose aspirin on serum placental growth factor levels in a high-risk PREDO cohort

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Author: Murtoniemi, K.1,2; Vahlberg, T.3; Hämäläinen, E.4,5;
Organizations: 1Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, P.O. Box 63, FI-00014 University of Helsinki, Finland
2Department of Obstetrics and Gynaecology, University of Turku and Turku University Hospital, PO Box 52, FI-20521 Turku, Finland
3Department of Clinical Medicine, Biostatistics, University of Turku and Turku University Hospital, FI-20014 University of Turku, Finland
4Vita Healthcare Service Ltd., Laivakatu 5 F, FI-00150 Helsinki, Finland
5Department of Clinical Chemistry, University of Helsinki, Helsinki, Finland
6National Institute for Health and Welfare, Chronic Disease Prevention Unit, FI-00271 Helsinki, Finland
7Hospital for Children and Adolescents, University of Helsinki and Helsinki University Hospital, Stenbäckinkatu 11, P.O. Box 281, FI-00029 HUS, Finland
8PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, 90014 Oulu, Finland
9Department of Psychology and Logopedics, University of Helsinki, Faculty of Medicine, P.O.Box 63, FI-00014 University of Helsinki, Finland
10Terveystalo Oy, Asemakatu 22-24, FI-70100 Kuopio, Finland
11Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Helsinki, Haartmaninkatu 2, P.O. Box 140, FI-00029 HUS, Finland
12Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, P.O.Box 20, FI-00014 University of Helsinki, Finland
13Department of Obstetrics and Gynecology, Tampere University Hospital, PO Box 2000, FI-33521 Tampere, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2018102638876
Language: English
Published: Elsevier, 2018
Publish Date: 2019-04-07
Description:

Abstract

Objectives: Our first aim was to study the longitudinal changes of serum placental growth factor (PlGF) concentration between 12+0 and 28+0 weeks of gestation in the prospective PREDO cohort. Our second aim was to study the effect of low-dose acetylsalicylic acid (LDA; 100 mg/day), started before the 14th week of gestation, on PlGF concentration.

Study design: Blood samples were collected at 12+0–14+0, 18+0–20+0 and 26+0–28+0 weeks of gestation in 101 women without and 309 with clinical risk factors for pre-eclampsia. Risk-women were divided into two groups: to those who had medium risk for pre-eclampsia and to those who had high risk for pre-eclampsia. Finally there were seven groups according to risk, treatment (no prevention/placebo/LDA) and outcome measure pre-eclampsia. Longitudinal changes in the PlGF concentration between groups were compared. To investigate the effect of LDA on serum PlGF concentration, placebo (N = 62) and LDA (N = 61) groups were compared. A repeated measures ANOVA was used to analyze differences in PlGF levels between the groups.

Results: The increase in serum PlGF concentration was higher in LDA than in placebo group (time × group effect, p = 0.046). The increase in serum PlGF concentration during pregnancy was lower in high-risk women who had placebo and developed pre-eclampsia and in medium-risk women who developed pre-eclampsia compared to the other women (time × group effect, p < 0.001). There were no differences in PlGF change between low-risk women, medium-risk women who did not develop pre-eclampsia, high-risk women in the placebo group without pre-eclampsia and high-risk women in the LDA group with and without pre-eclampsia (p = 0.15).

Conclusions: Our finding suggests an association between LDA started before 14 weeks of gestation and higher increase in serum PlGF concentration.

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Series: Pregnancy hypertension
ISSN: 2210-7789
ISSN-E: 2210-7797
ISSN-L: 2210-7789
Volume: 13
Pages: 51 - 57
DOI: 10.1016/j.preghy.2018.04.003
OADOI: https://oadoi.org/10.1016/j.preghy.2018.04.003
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
Subjects:
Copyright information: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
  https://creativecommons.org/licenses/by-nc-nd/4.0/