Emran, S.; Lappalainen, R.; Kullaa, A.M.; Myllymaa, S. Concentric Ring Probe for Bioimpedance Spectroscopic Measurements: Design and Ex Vivo Feasibility Testing on Pork Oral Tissues. Sensors 2018, 18, 3378.
Concentric ring probe for bioimpedance spectroscopic measurements : design and ex vivo feasibility testing on pork oral tissues
|Author:||Emran, Shekh1; Lappalainen, Reijo1; Kullaa, Arja M.2,3,4;|
1SIB Labs, Department of Applied Physics, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland
2Institute of Dentistry, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland
3Research Unit of Oral Health Sciences, University of Oulu, P.O. Box 8000, FI-90014 Oulu, Finland
4Educational Dental Clinic, Kuopio University Hospital, P.O. Box 100, FI-70029 Kuopio, Finland
|Online Access:||PDF Full Text (PDF, 2.2 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2018103042038
Multidisciplinary Digital Publishing Institute,
|Publish Date:|| 2018-10-30
Many oral diseases, such as oral leukoplakia and erythroplakia, which have a high potential for malignant transformations, cause abnormal structural changes in the oral mucosa. These changes are clinically assessed by visual inspection and palpation despite their poor accuracy and subjective nature. We hypothesized that non-invasive bioimpedance spectroscopy (BIS) might be a viable option to improve the diagnostics of potentially malignant lesions. In this study, we aimed to design and optimize the measurement setup and to conduct feasibility testing on pork oral tissues. The contact pressure between a custom-made concentric ring probe and tissue was experimentally optimized. The effects of loading time and inter-electrode spacing on BIS spectra were also clarified. Tissue differentiation testing was performed for ex vivo pork oral tissues including palatinum, buccal mucosa, fat, and muscle tissue samples. We observed that the most reproducible results were obtained by using a loading weight of 200 g and a fixed time period under press, which was necessary to allow meaningful quantitative comparison. All studied tissues showed their own unique spectra, accompanied by significant differences in both impedance magnitude and phase (p ≤ 0.014, Kruskal-Wallis test). BIS shows promise, and further studies are warranted to clarify its potential to detect specific pathological tissue alterations.
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
217 Medical engineering
114 Physical sciences
This research was funded by the Finnish Funding Agency for Technology and Innovation (Tekes) project “Novel spectroscopic methods for early detection and screening of oral cancer”, grant number 52/31/2014.
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).