University of Oulu

Choi, N.-R., Sándor, G., & Kim, Y.-D. (2018). Efficacy of Collagen-Based Membranes in Alveolar Bone Augmentation. Applied Sciences, 8(11), 2048. doi:10.3390/app8112048

Efficacy of collagen-based membranes in alveolar bone augmentation

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Author: Choi, Na-Rae1; Sándor, George K.2,3; Kim, Yong-Deok1
Organizations: 1Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University
2Department of Oral and Maxillofacial Surgery, Oulu University Hospital and Medical Research Center, University of Oulu
3BioMediTech, Institute of Biosciences and Medical Technology, University of Tampere
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.6 MB)
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Language: English
Published: Multidisciplinary Digital Publishing Institute, 2018
Publish Date: 2018-11-16


Collagen-based membranes (CBMs) have similar permissive bone formation capabilities when compared to non-absorbable membranes. CBMs have been classified as non-cross-linked membranes (NCLMs) and cross-linked membranes (CLMs) depending on whether the cross-linking between the collagen fibers was artificially increased. The purpose of this study is to evaluate the bone maintenance capacity between NCLMs and CLMs by comparing resorption of regenerated bone. The inclusion criteria consisted of: (1) The use of a CBM, either being an NCLM or CLM for coverage of grafted bone; (2) follow-up for more than one year; (3) the presence of the patient’s orthopantomographic X-ray (OPTG) immediately following the installation of implants and one year after. The bone resorption observed in the OPTG was determined by measuring the number of exposed threads of the implant. The number of thread exposures in the implant was compared according to CBM types. OPTGs taken immediately following the installation of implants and at one year after installation were compared. The subject of the measurement was always the implant in which the greatest number of exposed threads were present in each patient. A total of 56 subjects and 97 implants were used in this study. There was no significant difference between NCLM and CLM groups (p > 0.05). However, there was a statistically significant difference (p = 0.02) between the groups when a bone graft was applied to both the maxilla and the mandible. The average number of thread exposures was less than 1.5. In this study, no comparison was made between commonly known causes of bone loss and membrane types.

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Series: Applied sciences
ISSN: 2076-3417
ISSN-E: 2076-3417
ISSN-L: 2076-3417
Volume: 8
Issue: 11
Article number: 2048
DOI: 10.3390/app8112048
Type of Publication: A1 Journal article – refereed
Field of Science: 313 Dentistry
Funding: This study was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (NRF-2018R1A5A2023879) and a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI17C0708).
Copyright information: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (