University of Oulu

Rytkönen E, Ottavainen V, Rytkönen A, Uusitalo S, Lehenkari P, Sándor GK. Denosumab treatment for aggressive multiple recurrent familial central giant-cell granulomas. Ann Maxillofac Surg 2018;8:265-9. Available from:

Denosumab treatment for aggressive multiple recurrent familial central giant-cell granulomas

Saved in:
Author: Rytkönen, Eelis1; Ottavainen, Vuokko1; Rytkönen, Aleksi2;
Organizations: 1Department of Oral and Maxillofacial Surgery, Oulu University Hospital, Oulu, Finland
2Department of Pathology, Oulu University Hospital, Oulu, Finland
3Department of Anatomy, University of Oulu
4Department of Orthopaedics, Oulu University Hospital
5Department of Oral and Maxillofacial Surgery, University of Oulu and Oulu University Hospital, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1 MB)
Persistent link:
Language: English
Published: Wolters Kluwer, 2018
Publish Date: 2019-01-02


Background: Aggressive familial giant-cell granulomas of the jaws can be severely deforming. Surgical and nonsurgical treatments may be associated with multiple recurrences. Denosumab, a new generation antiresorptive drug, is an osteoclast inhibitor, which may be particularly useful to manage such potentially disfiguring lesions.

Materials and Methods: Two sisters, both with a history of multiple recurrent aggressive central giant-cell granuloma (CGCG)-like lesions in both jaws, were referred for management. All lesions were histologically consistent with the diagnosis of CGCG. The lesions were treated surgically with curettage and perilesional injection of triamcinolone. In particular, the older sister had four separate anatomic sites where some of her lesions had multiple recurrences necessitating three repeat procedures. A course of subcutaneous denosumab was administered following the last giant-cell granuloma removal in both sisters.

Results: Bony healing was normal. No further recurrences were observed over 3.5 years of follow-up after denosumab therapy in either sister.

Conclusions: In this small cohort comprising two sisters with multiple aggressive recurrent giant-cell granuloma lesions at multiple sites in the mouth, subcutaneous denosumab administration was associated with success over 3.5 years of follow-up. This report cautiously adds to the clinical experience in the use of denosumab for the treatment of recurrent aggressive familial CGCG lesions.

see all

Series: Annals of maxillofacial surgery
ISSN: 2231-0746
ISSN-E: 2249-3816
ISSN-L: 2231-0746
Volume: 8
Issue: 2
Pages: 265 - 269
DOI: 10.4103/ams.ams_192_18
Type of Publication: A1 Journal article – refereed
Field of Science: 3126 Surgery, anesthesiology, intensive care, radiology
Funding: Oulu University Hospital VTR Grants, Oulu, Finland.
Copyright information: © 2018 Annals of Maxillofacial Surgery | Published by Wolters Kluwer - Medknow. This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution‑NonCommercial‑ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non‑commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.