University of Oulu

Tu, H., Pirskanen-Matell, R., Heikkinen, A., Oikarainen, T., Risteli, J. and Pihlajaniemi, T. (2018), Autoimmune antibodies to collagen XIII in myasthenia gravis patients. Muscle Nerve, 57: 506-510.

Autoimmune antibodies to collagen XIII in myasthenia gravis patients

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Author: Tu, Hongmin1; Pirskanen‐Matell, Ritva2; Heikkinen, Anne1;
Organizations: 1Centre of Excellence in Cell‐Extracellular Matrix Research, Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu
2Department of Neurology, Karolinska University Hospital Solna
3Department of Clinical Chemistry, Cancer and Translational Medicine Research Unit, Medical Research Center, University of Oulu and Northern Finland Laboratory Centre NordLab, Oulu University Hospital
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.8 MB)
Persistent link:
Language: English
Published: John Wiley & Sons, 2017
Publish Date: 2019-01-03


Introduction: Evaluation of the nerve fascicular structure can be useful in diagnosing nerve damage, but it is a very challenging task with 3T MRI because of limited resolution. In this pilot study, we present the feasibility of high‐resolution 7T MRI for examining the nerve fascicular structure.

Methods: A 3‐dimensional (3D) gradient‐spoiled sequence was used for imaging peripheral nerves in extremities. Images acquired with different in‐plane resolutions (0.42 × 0.42 mm vs. 0.12 × 0.12 mm), and different main field strengths (7T vs. 3T) were compared.

Results: The individual nerve fascicles were identified at 0.12 × 0.12 mm resolution in both field strengths but not at 0.42 × 0.42 mm resolution. The fascicular structure was more sharply depicted in 7T images than in 3T images.

Discussion: High‐resolution 3D imaging with 7T MRI demonstrated feasibility for imaging nerve fascicular structures.

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Series: Muscle & nerve
ISSN: 0148-639X
ISSN-E: 1097-4598
ISSN-L: 0148-639X
Volume: 57
Issue: 3
Pages: 506 - 510
DOI: 10.1002/mus.25969
Type of Publication: A1 Journal article – refereed
Field of Science: 1182 Biochemistry, cell and molecular biology
Funding: Academy of Finland (Centre of Excellence Grant 2012–2017 284605 to T.P.); and the Sigrid Juselius Foundation.
Academy of Finland Grant Number: 284605
Detailed Information: 284605 (Academy of Finland Funding decision)
Copyright information: © 2017 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Tu, H. , Pirskanen‐Matell, R. , Heikkinen, A. , Oikarainen, T. , Risteli, J. and Pihlajaniemi, T. (2018), Autoimmune antibodies to collagen XIII in myasthenia gravis patients. Muscle Nerve, 57: 506-510, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.