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Li, W., Hirvasniemi, J., Guo, X., Saarakkala, S., Lammi, M., Qu, C. (2018) Comparison of bone texture between normal individuals and patients with Kashin-Beck disease from plain radiographs in knee. Scientific Reports, 8 (1), 17510. doi:10.1038/s41598-018-35552-8

Comparison of bone texture between normal individuals and patients with Kashin-Beck disease from plain radiographs in knee

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Author: Li, Wenrong1,2; Hirvasniemi, Jukka3; Guo, Xiong2;
Organizations: 1Department of Medical Imaging, The First Affiliated Hospital of Xi´an Jiaotong University
2School of Public Health, Xi´an Jiaotong University Health Science Center
3Center for Machine Vision and Signal Analysis, Faculty of Information Technology and Electrical Engineering, University of Oulu
4Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu
5Medical Research Center Oulu, Oulu University Hospital and University of Oulu
6Department of Diagnostic Radiology, Oulu University Hospital
7Department of Integrative Molecular Biology, Umeå University
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.4 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe201901031230
Language: English
Published: Springer Nature, 2018
Publish Date: 2019-01-03
Description:

Abstract

To compare tibial bone texture between Kashin-Beck disease (KBD) patients and normal individuals from plain radiographs using an advanced image analysis. Plain knee radiographs were obtained from KBD patients (n = 49) and age-matched healthy controls (n = 98). KBD were graded with diagnostic criteria WS/T 207-2010. The textural values related to bone structure from medial and lateral tibial subchondral and trabecular bones were evaluated using entropy of Laplacian-based image (ELap), entropy of local binary patterns (ELBP), homogeneity indices (HI) of local angles (HIMean, HIPerp and HIParal), and fractal dimensions from horizontal (FDHor) and vertical (FDVer) structures. KBD patients were shorter in height and lighter in weight, and their tibial width was wider than controls. Anatomical angle of KBD patients showed more genu valgus. Total KBD patients and subgroups had higher ELap, HIMean, HIPerp and HIParal in detected tibial subchondral and trabecular bones than controls, except ELap in lateral subchondral bone. ELBP, FDHor and FDVer from the detected tibial bone in KBD patients and subgroups were lower than controls, except FDVer in lateral trabecular bone. Our results indicate that micro-scale in bone texture in KBD-affected knees can be quantitatively examined from plain radiographs using an advanced image analysis.

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Series: Scientific reports
ISSN: 2045-2322
ISSN-E: 2045-2322
ISSN-L: 2045-2322
Volume: 8
Article number: 17510
DOI: 10.1038/s41598-018-35552-8
OADOI: https://oadoi.org/10.1038/s41598-018-35552-8
Type of Publication: A1 Journal article – refereed
Field of Science: 3126 Surgery, anesthesiology, intensive care, radiology
3111 Biomedicine
Subjects:
Article
Funding: The authors express their appreciation for the support of Faculty of Medicine, Umeå University, Academy of Finland (grant nos 268378 and 308165) and Key international cooperation research project of the National Natural Science Foundation of China (grant no. 8162010826).
Academy of Finland Grant Number: 268378
308165
Detailed Information: 268378 (Academy of Finland Funding decision)
308165 (Academy of Finland Funding decision)
Copyright information: © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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