University of Oulu

Peppi Koivunen, Thomas Kietzmann, Hypoxia-Inducible Factor Prolyl 4-Hydroxylases and Metabolism, Trends in Molecular Medicine, Volume 24, Issue 12, 2018, Pages 1021-1035, ISSN 1471-4914, https://doi.org/10.1016/j.molmed.2018.10.004

Hypoxia-inducible factor prolyl 4-hydroxylases and metabolism

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Author: Koivunen, Peppi1; Kietzmann, Thomas2
Organizations: 1Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland
2Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe201901071495
Language: English
Published: Elsevier, 2018
Publish Date: 2019-11-01
Description:

Abstract

Hypoxia-inducible factor prolyl 4-hydroxylases (HIF-P4Hs, also known as PHDs or EglNs) are enzymes that act as cellular oxygen sensors. Inhibition of HIF-P4Hs leads to stabilization of hypoxia-inducible transcription factors (HIFs), which initiates a gene expression program that allows organisms to cope with low oxygen levels and restore tissue oxygenation. This involves, for example, upregulation of erythropoiesis and angiogenesis, modulation of inflammatory responses, and reprogramming of metabolism. Currently, several pharmacological HIF-P4H inhibitors are in clinical trials mainly for renal anemia. However, recent data suggest that HIF-P4H inhibitors could also be considered to treat metabolic disorders. Here, we discuss the potential of targeting HIF-P4Hs and the HIF pathway for the treatment of obesity, metabolic syndrome, atherosclerosis, and fatty liver diseases (FLDs).

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Series: Trends in molecular medicine
ISSN: 1471-4914
ISSN-E: 1471-499X
ISSN-L: 1471-4914
Volume: 24
Issue: 12
Pages: 1021 - 1035
DOI: 0.1016/j.molmed.2018.10.004
OADOI: https://oadoi.org/0.1016/j.molmed.2018.10.004
Type of Publication: A2 Review article in a scientific journal
Field of Science: 1182 Biochemistry, cell and molecular biology
Subjects:
Copyright information: © 2018 Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
  https://creativecommons.org/licenses/by-nc-nd/4.0/