University of Oulu

Ushenko, V., Sdobnov, A., Syvokorovskaya, A., Dubolazov, A., Vanchulyak, O., Ushenko, A., Ushenko, Y., Gorsky, M., Sidor, M., Bykov, A., Meglinski, I. (2018) 3D Mueller-Matrix Diffusive Tomography of Polycrystalline Blood Films for Cancer Diagnosis. Photonics, 5 (4), 54. doi:10.3390/photonics5040054

3D Mueller-matrix diffusive tomography of polycrystalline blood films for cancer diagnosis

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Author: Ushenko, Volodimir1; Sdobnov, Anton2; Syvokorovskaya, Anna3;
Organizations: 1Optics and Publishing Department, Chernivtsi National University, 2 Kotsiubynskyi Str., 58012 Chernivtsi, Ukraine
2Opto-Electronic and Measurement Techniques, University of Oulu, P. O. Box 4500, 90014 Oulu, Finland
3Department of Forensic Medicine, Bukovinian State Medical University, 3 Theatral Sq., 58000 Chernivtsi, Ukraine
4Interdisciplinary Laboratory of Biophotonics, National Research Tomsk State University, 634050 Tomsk, Russia
5Institute of Engineering Physics for Biomedicine (PhysBio), National Research Nuclear University “MEPhI”, 15409 Moscow, Russia
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Version: published version
Access: open
Online Access: PDF Full Text (PDF, 3.7 MB)
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Language: English
Published: Multidisciplinary Digital Publishing Institute, 2018
Publish Date: 2019-01-23


The decomposition of the Mueller matrix of blood films has been carried out using differential matrices with polarized and depolarized parts. The use of a coherent reference wave is applied and the algorithm of digital holographic reconstruction of the field of complex amplitudes is used. On this basis, the 3D Mueller-matrix diffuse tomography method — the reconstruction of distributions of fluctuations of linear and circular birefringence of depolarizing polycrystalline films of human blood is analytically justified and experimentally tested. The dynamics of the change in the magnitude of the statistical moments of the first-fourth order, which characterize layer-by-layer distributions of fluctuations in the phase anisotropy of the blood film, is examined and analyzed. The most sensitive parameters for prostate cancer are the statistical moments of the third and fourth orders, which characterize the asymmetry and kurtosis of fluctuations in the linear and circular birefringence of blood films. The excellent accuracy of differentiation obtained polycrystalline films of blood from healthy donors and patients with cancer patients was achieved.

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Series: Photonics
ISSN: 2304-6732
ISSN-E: 2304-6732
ISSN-L: 2304-6732
Volume: 5
Issue: 4
Article number: 54
DOI: 10.3390/photonics5040054
Type of Publication: A1 Journal article – refereed
Field of Science: 114 Physical sciences
Funding: Authors acknowledge financial support of the Academy of Finland (grant projects: 314369 and 311698). ASand IM would like to express sincere thanks to INFOTECH. IM acknowledges partial support from the MEPhI Academic Excellence Project (Contract No. 02.a03.21.0005), and National Research Tomsk State University Academic D.I. Mendeleev Fund Program.
Academy of Finland Grant Number: 314369
Detailed Information: 314369 (Academy of Finland Funding decision)
311698 (Academy of Finland Funding decision)
Copyright information: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (