University of Oulu

Irina Y. Yanina, Alexey P. Popov, Alexander V. Bykov, Igor V. Meglinski, Valery V. Tuchin, “Monitoring of temperature-mediated phase transitions of adipose tissue by combined optical coherence tomography and Abbe refractometry,” J. Biomed. Opt. 23(1), 016003 (2018), doi: 10.1117/1.JBO.23.1.016003

Monitoring of temperature-mediated phase transitions of adipose tissue by combined optical coherence tomography and Abbe refractometry

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Author: Yanina, Irina1,2; Popov, Alexey3,4; Bykov, Alexander3,4;
Organizations: 1Saratov State University, Research-Educational Institute of Optics and Biophotonics, Saratov, Russia
2Tomsk State University, Interdisciplinary Laboratory of Biophotonics, Tomsk, Russia
3University of Oulu, Optoelectronics and Measurement Techniques Research Unit, Oulu, Finland
4ITMO University, Terahertz Biomedicine Laboratory, St. Petersburg, Russia
5Irkutsk State University, Institute of Biology, Irkutsk, Russia
6ITMO University, Laboratory of Femtomedicine, St. Petersburg, Russia
7Institute of Precision Mechanics and Control of the Russian Academy of Sciences, Laboratory of Laser Diagnostics of Technical and Living Systems, Saratov, Russia
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 2 MB)
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Language: English
Published: SPIE, 2018
Publish Date: 2019-02-08


Observation of temperature-mediated phase transitions between lipid components of the adipose tissues has been performed by combined use of the Abbe refractometry and optical coherence tomography. The phase transitions of the lipid components were clearly observed in the range of temperatures from 24°C to 60°C, and assessed by quantitatively monitoring the changes of the refractive index of 1- to 2-mmthick porcine fat tissue slices. The developed approach has a great potential as an alternative method for obtaining accurate information on the processes occurring during thermal lipolysis.

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Series: Journal of biomedical optics
ISSN: 1083-3668
ISSN-E: 1560-2281
ISSN-L: 1083-3668
Volume: 23
Issue: 1
Article number: 016003
DOI: 10.1117/1.JBO.23.1.016003
Type of Publication: A1 Journal article – refereed
Field of Science: 213 Electronic, automation and communications engineering, electronics
217 Medical engineering
Funding: The authors thank Dr. S. V. Eremina (Department of English and Intercultural Communication of Saratov State University) for proof of English, L.E. Dolotov for help in design of the registration part of the AR Atago DR-M2 1550 (Atago, Japan). This study was supported in part by Academy of Finland projects Grants 288164 (I.Yu.Y.), 260321 and 290596 (A.P.P., A.V.B.); the Russian Presidential Grant Nos. MK-6009.2016.2 (I.Yu.Y.) and NSh-7898.2016.2 (V.V.T. and I.Yu.Y.), the Government of Russian Federation Grant No. 074-U01 (A.P.P., A.V.B., I.V.M., and V.V.T.), and the Tomsk State University Competitiveness Improvement Programme (I.Yu.Y. and V.V.T.). I.V.M. also acknowledges a partial support provided by the Russian Science Foundation project No. 15-14-10008. All authors have no financial interest.
Academy of Finland Grant Number: 288164
Detailed Information: 288164 (Academy of Finland Funding decision)
260321 (Academy of Finland Funding decision)
290596 (Academy of Finland Funding decision)
Copyright information: © 2018 Society of Photo-Optical Instrumentation Engineers (SPIE).