Speckle dynamics under ergodicity breaking
|Author:||Anton, Sdobnov1; Alexander, Bykov1; Molodij, Guillaume2;|
1Faculty of Information Technology and Electrical Engineering, University of Oulu, Oulu 90570, Finland
2Department of Veterinary Resources, Weizmann Institute of Science, Rehovot 76100, Israel
3Interdisciplinary Laboratory of Biophotonics, National Research Tomsk State University, Tomsk 634050, Russia
4Institute of Engineering Physics for Biomedicine (PhysBio), National Research Nuclear University MEPhI, 115409 Moscow, Russia
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe201902114462
|Publish Date:|| 2019-03-26
Laser speckle contrast imaging (LSCI) is a well-known and versatile approach for the non-invasive visualization of flows and microcirculation localized in turbid scattering media, including biological tissues. In most conventional implementations of LSCI the ergodic regime is typically assumed valid. However, most composite turbid scattering media, especially biological tissues, are non-ergodic, containing a mixture of dynamic and static centers of light scattering. In the current study, we examined the speckle contrast in different dynamic conditions with the aim of assessing limitations in the quantitative interpretation of speckle contrast images. Based on a simple phenomenological approach, we introduced a coefficient of speckle dynamics to quantitatively assess the ratio of the dynamic part of a scattering medium to the static one. The introduced coefficient allows one to distinguish real changes in motion from the mere appearance of static components in the field of view. As examples of systems with static/dynamic transitions, thawing and heating of Intralipid samples were studied by the LSCI approach.
Journal of physics. D, Applied physics
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
114 Physical sciences
This work was supported by the CIMO Fellowships program (21.3.16/TM-16-10089/CIMO Fellowship/WS19), EDUFI Fellowship program (13.10.17/TM-17-10655/EDUFI Fellowship/ WS 19), the Academy of Finland (Grant No. 290596), the Tomsk State University Academic D I Mendeleev Fund Program and the National Research Nuclear University MEPhI’s Academic Excellence Project (Contract No. 02.a03.21.0005). The authors are grateful to A Dombovari, MSc, and Dr G Lorite for their help in the preparation of samples and their useful discussions.
|Academy of Finland Grant Number:||
290596 (Academy of Finland Funding decision)
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