University of Oulu

Petr Štěpánek, Clara Sanchez-Perez, Ville-Veikko Telkki, Vladimir V. Zhivonitko, Anu M. Kantola, High-throughput continuous-flow system for SABRE hyperpolarization, Journal of Magnetic Resonance, Volume 300, 2019, Pages 8-17, ISSN 1090-7807, https://doi.org/10.1016/j.jmr.2019.01.003

High-throughput continuous-flow system for SABRE hyperpolarization

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Author: Štěpánek, Petr1; Sanchez-Perez, Clara2,3; Telkki, Ville-Veikko1;
Organizations: 1NMR Research Unit, Faculty of Science, University of Oulu, P.O. Box 3000, FI-90014, Finland
2Environmental and Chemical Engineering, Faculty of Technology, University of Oulu, FI-90014, Finland
3Present address: Department of Chemistry, University College London, 20 Gordon Street London WC1H 0AJ, United Kingdom
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.2 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe201902185266
Language: English
Published: Elsevier, 2019
Publish Date: 2019-02-18
Description:

Abstract

Signal Amplification By Reversible Exchange (SABRE) is a versatile method for hyperpolarizing small organic molecules that helps to overcome the inherent low signal-to-noise ratio of nuclear magnetic resonance (NMR) measurements. It offers orders of magnitude enhanced signal strength, but the obtained nuclear polarization usually rapidly relaxes, requiring a quick transport of the sample to the spectrometer. Here we report a new design of a polarizing system, which can be used to prepare a continuous flow of SABRE-hyperpolarized sample with a considerable throughput of several millilitres per second and a rapid delivery into an NMR instrument. The polarizer performance under different conditions such as flow rate of the hydrogen or liquid sample is tested by measuring a series of NMR spectra and magnetic resonance images (MRI) of hyperpolarized pyridine in methanol. Results show a capability to continuously produce sample with dramatically enhanced signal over two orders of magnitude. The constant supply of hyperpolarized sample can be exploited, e.g., in experiments requiring multiple repetitions, such as 2D- and 3D-NMR or MRI measurements, and also naturally allows measurements of flow maps, including systems with high flow rates, for which the level of achievable thermal polarization might not be usable any more. In addition, the experiments can be viably carried out in a non-deuterated solvent, due to the effective suppression of the thermal polarization by the fast sample flow. The presented system opens the possibilities for SABRE experiments requiring a long-term, stable and high level of nuclear polarization.

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Series: Journal of magnetic resonance
ISSN: 1090-7807
ISSN-E: 1096-0856
ISSN-L: 1090-7807
Volume: 300
Pages: 8 - 17
DOI: /10.1016/j.jmr.2019.01.003
OADOI: https://oadoi.org//10.1016/j.jmr.2019.01.003
Type of Publication: A1 Journal article – refereed
Field of Science: 114 Physical sciences
116 Chemical sciences
Subjects:
MRI
Funding: This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement NMOSPEC No 654967 (PS) and from Academy of Finland (Grant 316180) (PS). We acknowledge the generous support provided by the European Research Council (ERC) under Horizon 2020 (H2020/2018-2022/ERC grant agreement No. 772110) and the Academy of Finland (Grant Nos. 289649 and 294027). We also thank the Magnus Ehrnrooth Foundation for financial support (PS). The authors acknowledge financial support from the Kvantum institute (University of Oulu).
EU Grant Number: (654967) NMOSPEC - Experimental Nuclear Magneto-Optic Spectroscopy
(772110) UFLNMR - Ultrafast Laplace NMR
Academy of Finland Grant Number: 316180
289649
294027
Detailed Information: 316180 (Academy of Finland Funding decision)
289649 (Academy of Finland Funding decision)
294027 (Academy of Finland Funding decision)
Copyright information: © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
  https://creativecommons.org/licenses/by/4.0/