High-throughput continuous-flow system for SABRE hyperpolarization |
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Author: | Štěpánek, Petr1; Sanchez-Perez, Clara2,3; Telkki, Ville-Veikko1; |
Organizations: |
1NMR Research Unit, Faculty of Science, University of Oulu, P.O. Box 3000, FI-90014, Finland 2Environmental and Chemical Engineering, Faculty of Technology, University of Oulu, FI-90014, Finland 3Present address: Department of Chemistry, University College London, 20 Gordon Street London WC1H 0AJ, United Kingdom |
Format: | article |
Version: | published version |
Access: | open |
Online Access: | PDF Full Text (PDF, 1.2 MB) |
Persistent link: | http://urn.fi/urn:nbn:fi-fe201902185266 |
Language: | English |
Published: |
Elsevier,
2019
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Publish Date: | 2019-02-18 |
Description: |
AbstractSignal Amplification By Reversible Exchange (SABRE) is a versatile method for hyperpolarizing small organic molecules that helps to overcome the inherent low signal-to-noise ratio of nuclear magnetic resonance (NMR) measurements. It offers orders of magnitude enhanced signal strength, but the obtained nuclear polarization usually rapidly relaxes, requiring a quick transport of the sample to the spectrometer. Here we report a new design of a polarizing system, which can be used to prepare a continuous flow of SABRE-hyperpolarized sample with a considerable throughput of several millilitres per second and a rapid delivery into an NMR instrument. The polarizer performance under different conditions such as flow rate of the hydrogen or liquid sample is tested by measuring a series of NMR spectra and magnetic resonance images (MRI) of hyperpolarized pyridine in methanol. Results show a capability to continuously produce sample with dramatically enhanced signal over two orders of magnitude. The constant supply of hyperpolarized sample can be exploited, e.g., in experiments requiring multiple repetitions, such as 2D- and 3D-NMR or MRI measurements, and also naturally allows measurements of flow maps, including systems with high flow rates, for which the level of achievable thermal polarization might not be usable any more. In addition, the experiments can be viably carried out in a non-deuterated solvent, due to the effective suppression of the thermal polarization by the fast sample flow. The presented system opens the possibilities for SABRE experiments requiring a long-term, stable and high level of nuclear polarization. see all
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Series: |
Journal of magnetic resonance |
ISSN: | 1090-7807 |
ISSN-E: | 1096-0856 |
ISSN-L: | 1090-7807 |
Volume: | 300 |
Pages: | 8 - 17 |
DOI: | 10.1016/j.jmr.2019.01.003 |
OADOI: | https://oadoi.org/10.1016/j.jmr.2019.01.003 |
Type of Publication: |
A1 Journal article – refereed |
Field of Science: |
114 Physical sciences 116 Chemical sciences |
Subjects: | |
Funding: |
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement NMOSPEC No 654967 (PS) and from Academy of Finland (Grant 316180) (PS). We acknowledge the generous support provided by the European Research Council (ERC) under Horizon 2020 (H2020/2018-2022/ERC grant agreement No. 772110) and the Academy of Finland (Grant Nos. 289649 and 294027). We also thank the Magnus Ehrnrooth Foundation for financial support (PS). The authors acknowledge financial support from the Kvantum institute (University of Oulu). |
EU Grant Number: |
(654967) NMOSPEC - Experimental Nuclear Magneto-Optic Spectroscopy (772110) UFLNMR - Ultrafast Laplace NMR |
Academy of Finland Grant Number: |
316180 289649 294027 |
Detailed Information: |
316180 (Academy of Finland Funding decision) 289649 (Academy of Finland Funding decision) 294027 (Academy of Finland Funding decision) |
Copyright information: |
© 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
https://creativecommons.org/licenses/by/4.0/ |