University of Oulu

Bell, GA, Männistö, T, Liu, A, et al. The joint role of thyroid function and iodine concentration on gestational diabetes risk in a population‐based study. Acta Obstet Gynecol Scand. 2019; 98: 500– 506. https://doi.org/10.1111/aogs.13523

The joint role of thyroid function and iodine concentration on gestational diabetes risk in a population‐based study

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Author: Bell, Griffith A.1; Männistö, Tuija2; Liu, Aiyi1;
Organizations: 1Division of Intramural Population Health Research, National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA
2Northern Finland Laboratory Center NordLab, Oulu University and Oulu University Hospital, Oulu, Finland
3Wadsworth Center, New York State Department of Health, Albany, NY, USA
4Biobank Borealis of Northern Finland, Oulu University Hospital, Oulu, Finland
5Faculty of Medicine, University of Oulu, Oulu, Finland
6National Institute of Health and Welfare, Helsinki, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe201903209462
Language: English
Published: John Wiley & Sons, 2019
Publish Date: 2019-12-23
Description:

Abstract

Introduction: Iodine is essential for thyroid function, and iodine deficiency during pregnancy is common in Europe and the USA. However, no published studies have examined the role of iodine deficiency in the relation between thyroid function and gestational diabetes mellitus (GDM).

Material and methods: We conducted a population‐based, nested case‐control study within the Finnish Maternity Cohort using pregnancy and perinatal outcome data from the Finnish Maternal Birth Register. We randomly selected 224 GDM cases with singleton pregnancies and 224 controls without GDM from all singleton births occurring in Finland during 2012‐2013. Blood was drawn at 10‐14 weeks’ gestation and analyzed for serum iodide, thyroglobulin, and thyroid‐stimulating hormone (TSH) concentrations. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CI) of GDM.

Results: Very high thyroglobulin concentration (>95% percentile; >83 μg/L) was not associated with significantly altered odds of GDM compared to those with normal levels (OR 0.41; 95% CI: 0.12, 1.38). High concentrations of TSH were also not associated with increased odds of GDM compared to normal levels of TSH (OR 0.45; 95% CI: 0.06, 3.18). Women in the lowest 5th percentile (<1.58 ng/mL) of iodine did not have increased odds of GDM compared to those with iodide in the highest quartile (OR 0.39; 95% CI: 0.11, 1.35).

Conclusions: Low levels of iodide and thyroid function in early pregnancy are not associated with increased risk of GDM in this mildly iodine‐deficient population.

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Series: Acta obstetricia et gynecologica Scandinavica
ISSN: 0001-6349
ISSN-E: 1600-0412
ISSN-L: 0001-6349
Volume: 98
Issue: 4
Pages: 500 - 506
DOI: 10.1111/aogs.13523
OADOI: https://oadoi.org/10.1111/aogs.13523
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Subjects:
Copyright information: © 2018 Nordic Federation of Societies of Obstetrics and Gynecology. This is the peer reviewed version of the following article: Bell, GA, Männistö, T, Liu, A, et al. The joint role of thyroid function and iodine concentration on gestational diabetes risk in a population‐based study. Acta Obstet Gynecol Scand. 2019; 98: 500– 506, which has been published in final form at https://doi.org/10.1111/aogs.13523. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.