University of Oulu

Bengs, S. , Becker, E. , Busenhart, P. , Spalinger, M. R., Raselli, T. , Kasper, S. , Lang, S. , Atrott, K. , Mamie, C. , Vavricka, S. R., Boehmer, L. , Knuth, A. , Tuomisto, A. , Mäkinen, M. J., Hruz, P. , Turina, M. , Rickenbacher, A. , Petrowsky, H. , Weber, A. , Frei, P. , Halama, M. , Jenkins, G. , Sheppard, D. , Croner, R. S., Christoph, J. , Britzen‐Laurent, N. , Naschberger, E. , Schellerer, V. , Stürzl, M. , Fried, M. , Rogler, G. and Scharl, M. (2019), β6‐integrin serves as a novel serum tumor marker for colorectal carcinoma. Int. J. Cancer. doi:10.1002/ijc.32137

β6‐integrin serves as a novel serum tumor marker for colorectal carcinoma

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Author: Bengs, Susan1; Becker, Eugenia1; Busenhart, Philipp1;
Organizations: 1Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland
2Department of Immunology, Stanford University, Stanford, CA
3National Center for Cancer Care and Research NCCCR, Hamad Medical Corporation, Doha, Qatar
4Cancer and Translational Medicine Research Unit, Department of Pathology, University of Oulu, Oulu, Finland
5Oulu University Hospital and Medical Research Center Oulu, Oulu, Finland
6Department of Gastroenterology, University Hospital, Basel, Switzerland
7Department of Visceral and Transplant Surgery, University and University Hospital Zurich, Zürich, Switzerland
8Department of Pathology, Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
9Clinic for Gastroenterology Bethanien, Zürich, Switzerland
10Clinic for Gastroenterology Zurich-Fluntern, Zurich, Switzerland
11Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, United Kingdom
12Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, University of California, San Francisco, CA
13Department of Surgery, University Hospital Magdeburg, Magdeburg, Germany
14Department of Medical Informatics, University of Erlangen-Nuremberg, Erlangen, Germany
15Division of Molecular and Experimental Surgery, University Medical Center Erlangen, Erlangen, Germany
16Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2019040911662
Language: English
Published: John Wiley & Sons, 2019
Publish Date: 2020-01-17
Description:

Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer‐related deaths worldwide and the need for novel biomarkers and therapeutic strategies to improve diagnosis and surveillance is obvious. This study aims to identify β6‐integrin (ITGB6) as a novel serum tumor marker for diagnosis, prognosis, and surveillance of CRC. ITGB6 serum levels were validated in retro‐ and prospective CRC patient cohorts. ITGB6 serum levels were analyzed by ELISA. Using an initial cohort of 60 CRC patients, we found that ITGB6 is present in the serum of CRC, but not in non‐CRC control patients. A cut‐off of ≥2 ng/mL ITGB6 reveals 100% specificity for the presence of metastatic CRC. In an enlarged study cohort of 269 CRC patients, ITGB6 predicted the onset of metastatic disease and was associated with poor prognosis. Those data were confirmed in an independent, prospective cohort consisting of 40 CRC patients. To investigate whether ITGB6 can also be used for tumor surveillance, serum ITGB6‐levels were assessed in 26 CRC patients, pre‐ and post‐surgery, as well as during follow‐up visits. After complete tumor resection, ITGB6 serum levels declined completely. During follow‐up, a new rise in ITGB6 serum levels indicated tumor recurrence or the onset of new metastasis as confirmed by CT scan. ITGB6 was more accurate for prognosis of advanced CRC and for tumor surveillance as the established marker carcinoembryonic antigen (CEA). Our findings identify ITGB6 as a novel serum marker for diagnosis, prognosis, and surveillance of advanced CRC. This might essentially contribute to an optimized patient care.

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Series: International journal of cancer
ISSN: 0020-7136
ISSN-E: 1097-0215
ISSN-L: 0020-7136
Volume: In press
DOI: 10.1002/ijc.32137
OADOI: https://oadoi.org/10.1002/ijc.32137
Type of Publication: A1 Journal article – refereed
Field of Science: 3111 Biomedicine
Subjects:
Funding: Grant sponsors: Deutsche Forschungsgemeinschaft; Foundation for Scientific Research at the University of Zurich; Hartmann-Müller Foundation; Promedica Foundation, Chur; Stiftung Experimentelle Biomedizin; Swiss National Science Foundation; The German Research Foundation; Grant numbers: SFB/TRR241, DFG, RU2438; The Foundation for Scientific Research at the University of Zurich; The Hartmann-Müller Foundation; The Promedica Foundation, Chur; The Swiss National Science Foundation; Grant numbers: CRSII3 154488/1, 314730_166381, 314730_146204; Stiftung Experimentelle Biomedizin.
Copyright information: © 2019 UICC. This is the peer reviewed version of the following article: Bengs, S. , Becker, E. , Busenhart, P. , Spalinger, M. R., Raselli, T. , Kasper, S. , Lang, S. , Atrott, K. , Mamie, C. , Vavricka, S. R., Boehmer, L. , Knuth, A. , Tuomisto, A. , Mäkinen, M. J., Hruz, P. , Turina, M. , Rickenbacher, A. , Petrowsky, H. , Weber, A. , Frei, P. , Halama, M. , Jenkins, G. , Sheppard, D. , Croner, R. S., Christoph, J. , Britzen‐Laurent, N. , Naschberger, E. , Schellerer, V. , Stürzl, M. , Fried, M. , Rogler, G. and Scharl, M. (2019), β6‐integrin serves as a novel serum tumor marker for colorectal carcinoma. Int. J. Cancer. doi:10.1002/ijc.32137, which has been published in final form at https://doi.org/10.1002/ijc.32137. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.