Mapping of polycrystalline films of biological fluids utilizing the Jones-matrix formalism
|Author:||Ushenko, Vladimir A1; Dubolazov, Alexander V1; Pidkamin, Leonid Y1;|
1Yuriy Fedkovych Chernivtsi National University, 2 Kotsubinsky Str., 58012, Chernivtsi, Ukraine
2Opto-Electronics and Measurement Techniques, Faculty of Information Technology and Electrical Engineering, University of Oulu, Erkki Koiso-Kanttilankatu 3, Oulu 90570, Finland
3Interdisciplinary Laboratory of Biophotonics, National Research Tomsk State University, Prospect Lenina 36, Tomsk 634050, Russia
4ITMO University, Kronverkskiy Prospect 49, St Petersburg 197101, Russia
5Institute of Biology, Irkutsk State University, 3 Lenin St, Irkutsk 664003, Russia
6Institute of Engineering Physics for Biomedicine (PhysBio), National Research Nuclear University MEPhI, 115409 Moscow, Russia
|Online Access:||PDF Full Text (PDF, 3.1 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2019041011693
|Publish Date:|| 2019-04-10
Utilizing a polarized light approach, we reconstruct the spatial distribution of birefringence and optical activity in polycrystalline films of biological fluids. The Jones-matrix formalism is used for an accessible quantitative description of these types of optical anisotropy. We demonstrate that differentiation of polycrystalline films of biological fluids can be performed based on a statistical analysis of the distribution of rotation angles and phase shifts associated with the optical activity and birefringence, respectively. Finally, practical operational characteristics, such as sensitivity, specificity and accuracy of the Jones-matrix reconstruction of optical anisotropy, were identified with special emphasis on biomedical application, specifically for differentiation of bile films taken from healthy donors and from patients with cholelithiasis.
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
114 Physical sciences
This work was supported by the Strategic Action funding programme of the ITEE Faculty of the University of Oulu. IM also acknowledges partial support from the MEPhI Academic Excellence Project (Contract No. 02.a03.21.0005) and Russian Science Foundation (Grant No.: 15-14-10008).
© 2018 Astro Ltd. This is an author-created, un-copyedited version of an article published in Laser Physics. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.1088/1555-6611/aa8cd9.