University of Oulu

Lee, J.-Y., Kwon, J.-J., Sándor, G. K., & Kim, Y.-D. (2019). Effectiveness of Collagen Membrane in the Treatment of Schneiderian Membrane Perforation. Applied Sciences, 9(7), 1514. doi:10.3390/app9071514

Effectiveness of collagen membrane in the treatment of Schneiderian membrane perforation

Saved in:
Author: Lee, Jae-Yeol1,2; Kwon, Jin-Ju1; Sándor, George K.3,4;
Organizations: 1Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University
2Institute of Translational Dental Sciences & Dental Research Institute, Pusan National University
3Department of Oral and Maxillofacial Surgery, Oulu University Hospital and Medical Research Center, University of Oulu
4BioMediTech, Institute of Biosciences and Medical Technology, University of Tampere
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.8 MB)
Persistent link:
Language: English
Published: Multidisciplinary Digital Publishing Institute, 2019
Publish Date: 2019-04-24


Schneiderian membrane perforation (SMP) is the most common complication encountered during sinus lift procedures. SMPs should be managed to prevent loss of the valuable bone graft and bone substitute materials. A fast-resorbing collagen membrane (CM) is a soft, white, pliable, and nonfriable sponge used in dental surgery. The purpose of this study was to evaluate the clinical outcomes of SMP repair using CMs when an SMP had occurred during a sinus lifting procedure. The patients were divided into three groups according to the size of the SMPs during the sinus lift procedure. (A) Group 1: there was no perforation of the Schneiderian membrane but the membrane was weakened (or thinned) and repaired using CMs. (B) Group 2: the SMP was small to medium in size (< 10 mm) and repaired using CMs and fibrin adhesive (FA). (C) Group 3: the SMP was large in size (> 10 mm) and repaired using a collagen plug. The negative control group consisted of patients who did not have any SMP (Control) and these patients were randomly selected. Orthopantomographic X-rays taken before surgery, 2–3 days following surgery, and over 6 months after surgery (follow-up) were used to evaluate the acquired bone height according to groups. Bone heights were measured from the crestal bone at the planned implant placement sites. Clinical outcomes, including implant success and complications according to repair method, were also investigated. There was no significant difference in bone heights between the groups with the exception of group 3. The overall implant survival rate was 100% for implants placed in sinuses with frank SMPs or weakened sinus membranes. The CM is applicable for small-to-moderate perforations or sinus membranes which have been weakened or thinned during sinus lift procedures.

see all

Series: Applied sciences
ISSN: 2076-3417
ISSN-E: 2076-3417
ISSN-L: 2076-3417
Volume: 9
Issue: 7
DOI: 10.3390/app9071514
Type of Publication: A1 Journal article – refereed
Field of Science: 313 Dentistry
Funding: This study was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF-2018R1A5A2023879) and a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI17C0708).
Copyright information: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (