University of Oulu

Manninen, A., Varjosalo, M., Proteomics 2017, 1600022.

A proteomics view on integrin-mediated adhesions

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Author: Manninen, Aki1; Varjosalo, Markku2
Organizations: 1Biocenter Oulu, Oulu Center for Cell‐Matrix Research, Faculty of Biochemistry and Molecular Medicine University of Oulu Oulu Finland
2Institute of Biotechnology, Biocenter 3 University of Helsinki Helsinki Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 4.9 MB)
Persistent link:
Language: English
Published: John Wiley & Sons, 2017
Publish Date: 2017-10-06


Individual cells in multicellular organisms constantly explore their microenvironment, or niche, to obtain spatial information that is used to regulate cell behavior to maintain tissue integrity. The extracellular matrix (ECM) is an important source of such spatial information. Binding of the integrin family receptors to the ECM triggers formation of integrin adhesion complexes (IACs) that link the ECM network to cellular cytoskeleton via remarkably large multiprotein complexes collectively referred to as the integrin adhesome. Recent advances in proteomics have enabled researchers to study the IAC composition in detail. Various biochemical IAC isolation methods and culture conditions have been employed to study the composition and dynamics of integrin‐mediated adhesions mainly in fibroblasts and lymphoblasts. These studies have led to identification of daunting lists of potential IAC components. This review focuses on the current status of proteomics‐driven research seeking to understand integrin functions by comprehensive analysis of IAC components. These systems level approaches have revealed the complexity of biochemical and biomechanical signals that are processed at IACs and provide a novel insight into how these signals are conveyed to regulate cellular behavior.

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Series: Proteomics
ISSN: 1615-9853
ISSN-E: 1615-9861
ISSN-L: 1615-9853
Volume: 17
Issue: 3-4
DOI: 10.1002/pmic.201600022
Type of Publication: A2 Review article in a scientific journal
Field of Science: 3111 Biomedicine
Funding: This work was funded by Academy of Finland (A.M.: 140974, 263770, 135560 and M.V.: 288475).
Academy of Finland Grant Number: 140974
Detailed Information: 140974 (Academy of Finland Funding decision)
263770 (Academy of Finland Funding decision)
135560 (Academy of Finland Funding decision)
Copyright information: © 2016 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: Manninen, A., Varjosalo, M., Proteomics 2017, 1600022., which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.