University of Oulu

Eero Kajantie, Sonja Strang-Karlsson, Kari Anne Indredavik Evensen, Peija Haaramo, Adult outcomes of being born late preterm or early term – What do we know?, Seminars in Fetal and Neonatal Medicine, Volume 24, Issue 1, 2019, Pages 66-83, ISSN 1744-165X,

Adult outcomes of being born late preterm or early term : what do we know?

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Author: Kajantie, Eero1,2,3,4; Strang-Karlsson, Sonja1,3,5; Indredavik Evensen, Kari Anne4,6;
Organizations: 1National Institute for Health and Welfare, Public Health Promotion Unit, Helsinki, Oulu, Finland
2PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
3Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
4Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
5Department of Clinical Genetics, HUSLAB, Helsinki University Hospital, Helsinki, Finland
6Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.5 MB)
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Language: English
Published: Elsevier, 2019
Publish Date: 2019-11-03


The literature on adult outcomes of people born late preterm (LPT, 34–36 completed weeks) or early term (ET, 37–38 weeks) was reviewed. In PubMed, 9547 articles were identified; 53 were eligible. Of these, 12 were based on clinical cohorts, 32 on medical birth register linkages, and nine on historical birth cohorts; 48 out of 53 on Nordic countries; 50 out of 53 reported on LPT and eight out of 53 reported on ET. LPT plus ET have increased early (< 45 years) adult all-cause mortality. Despite increased cardiometabolic risk factors and slightly lower cardiorespiratory fitness in LPT, no studies showed increased risk for coronary heart disease, some showed increased risk for stroke, and all showed increased risk for type 2 diabetes. Most show increased risk for asthma and decreased allergic rhinitis. LPT have slightly lower cognitive abilities and higher rates of several mental disorders; ET have intermediate values. LPT and ET adults have slightly lower education, occupational status, and income. We recommend that authors report findings of LPT/ET separately from those born more preterm.

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Series: Seminars in fetal and neonatal medicine
ISSN: 1744-165X
ISSN-E: 1878-0946
ISSN-L: 1744-165X
Volume: 24
Issue: 1
Pages: 66 - 83
DOI: 10.1016/j.siny.2018.11.001
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
Copyright information: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license