University of Oulu

Ehret, G., Ferreira, T., Chasman, D., Jackson, A., Schmidt, E., Johnson, T., Thorleifsson, G., Luan, J., Donnelly, L., Kanoni, S., Petersen, A., Pihur, V., Strawbridge, R., Shungin, D., Hughes, M., Meirelles, O., Kaakinen, M., Bouatia-Naji, N., Kristiansson, K., Shah, S., Kleber, M., Guo, X., Lyytikäinen, L., Fava, C., Eriksson, N., Nolte, I., Magnusson, P., Salfati, E., Rallidis, L., Theusch, E., Smith, A., Folkersen, L., Witkowska, K., Pers, T., Joehanes, R., Kim, S., Lataniotis, L., Jansen, R., Johnson, A., Warren, H., Kim, Y., Zhao, W., Wu, Y., Tayo, B., Bochud, M., Absher, D., Adair, L., Amin, N., Arking, D., Axelsson, T., Baldassarre, D., Balkau, B., Bandinelli, S., Barnes, M., Barroso, I., Bevan, S., Bis, J., Bjornsdottir, G., Boehnke, M., Boerwinkle, E., Bonnycastle, L., Boomsma, D., Bornstein, S., Brown, M., Burnier, M., Cabrera, C., Chambers, J., Chang, I., Cheng, C., Chines, P., Chung, R., Collins, F., Connell, J., Döring, A., Dallongeville, J., Danesh, J., de Faire, U., Delgado, G., Dominiczak, A., Doney, A., Drenos, F., Edkins, S., Eicher, J., Elosua, R., Enroth, S., Erdmann, J., Eriksson, P., Esko, T., Evangelou, E., Evans, A., Fall, T., Farrall, M., Felix, J., Ferrières, J., Ferrucci, L., Fornage, M., Forrester, T., Franceschini, N., Franco, O., Franco-Cereceda, A., Fraser, R., Ganesh, S., Gao, H., Gertow, K., Gianfagna, F., Gigante, B., Giulianini, F., Goel, A., Goodall, A., Goodarzi, M., Gorski, M., Gräßler, J., Groves, C., Gudnason, V., Gyllensten, U., Hallmans, G., Hartikainen, A., Hassinen, M., Havulinna, A., Hayward, C., Hercberg, S., Herzig, K., Hicks, A., Hingorani, A., Hirschhorn, J., Hofman, A., Holmen, J., Holmen, O., Hottenga, J., Howard, P., Hsiung, C., Hunt, S., Ikram, M., Illig, T., Iribarren, C., Jensen, R., Kähönen, M., Kang, H., Kathiresan, S., Keating, B., Khaw, K., Kim, Y., Kim, E., Kivimaki, M., Klopp, N., Kolovou, G., Komulainen, P., Kooner, J., Kosova, G., Krauss, R., Kuh, D., Kutalik, Z., Kuusisto, J., Kvaløy, K., Lakka, T., Lee, N., Lee, I., Lee, W., Levy, D., Li, X., Liang, K., Lin, H., Lin, L., Lindström, J., Lobbens, S., Männistö, S., Müller, G., Müller-Nurasyid, M., Mach, F., Markus, H., Marouli, E., McCarthy, M., McKenzie, C., Meneton, P., Menni, C., Metspalu, A., Mijatovic, V., Moilanen, L., Montasser, M., Morris, A., Morrison, A., Mulas, A., Nagaraja, R., Narisu, N., Nikus, K., O'Donnell, C., O'Reilly, P., Ong, K., Paccaud, F., Palmer, C., Parsa, A., Pedersen, N., Penninx, B., Perola, M., Peters, A., Poulter, N., Pramstaller, P., Psaty, B., Quertermous, T., Rao, D., Rasheed, A., Rayner, N., Renström, F., Rettig, R., Rice, K., Roberts, R., Rose, L., Rossouw, J., Samani, N., Sanna, S., Saramies, J., Schunkert, H., Sebert, S., Sheu, W., Shin, Y., Sim, X., Smit, J., Smith, A., Sosa, M., Spector, T., Stančáková, A., Stanton, A., Stirrups, K., Stringham, H., Sundstrom, J., Swift, A., Syvänen, A., Tai, E., Tanaka, T., Tarasov, K., Teumer, A., Thorsteinsdottir, U., Tobin, M., Tremoli, E., Uitterlinden, A., Uusitupa, M., Vaez, A., Vaidya, D., van Duijn, C., van Iperen, E., Vasan, R., Verwoert, G., Virtamo, J., Vitart, V., Voight, B., Vollenweider, P., Wagner, A., Wain, L., Wareham, N., Watkins, H., Weder, A., Westra, H., Wilks, R., Wilsgaard, T., Wilson, J., Wong, T., Yang, T., Yao, J., Yengo, L., Zhang, W., Zhao, J., Zhu, X., Bovet, P., Cooper, R., Mohlke, K., Saleheen, D., Lee, J., Elliott, P., Gierman, H., Willer, C., Franke, L., Hovingh, G., Taylor, K., Dedoussis, G., Sever, P., Wong, A., Lind, L., Assimes, T., Njølstad, I., Schwarz, P., Langenberg, C., Snieder, H., Caulfield, M., Melander, O., Laakso, M., Saltevo, J., Rauramaa, R., Tuomilehto, J., Ingelsson, E., Lehtimäki, T., Hveem, K., Palmas, W., März, W., Kumari, M., Salomaa, V., Chen, Y., Rotter, J., Froguel, P., Jarvelin, M., Lakatta, E., Kuulasmaa, K., Franks, P., Hamsten, A., Wichmann, H., Palmer, C., Stefansson, K., Ridker, P., Loos, R., Chakravarti, A., Deloukas, P., Morris, A., Newton-Cheh, C., Munroe, P., (2016) The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nature Genetics, 48 (10), 1171-1184. doi:10.1038/ng.3667

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

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Author: Ehret, Georg B.1,2; Ferreira, Teresa3; Chasman, Daniel I.4,5;
Jackson, Anne U.6,7; Schmidt, Ellen M.8; Johnson, Toby9,10; Thorleifsson, Gudmar11; Luan, Jian'an12; Donnelly, Louise A.13; Kanoni, Stavroula14; Petersen, Ann -Kristin15; Pihurl, Vasyl1; Strawbridge, Rona J.16,17; Shungin, Dmitry18,19,20; Hughes, Maria F.21; Meirelles, Osorio22; Kaakinen, Marika23; Bouatia-Naji, Nabila24,25; Kristiansson, Kati26,27; Shah, Sonia28; Kleber, Marcus E.29; Guo, Xiuqing30,31; Lyytikainen, Leo-Pekka32,33; Fava, Cristiano34,35; Eriksson, Nidas36; Nolte, Ilja M.37; Magnusson, Patrik K.38; Salfati, Elias L.39; Rallidis, Loukianos S.40; Theusch, Elizabeth41; Smith, Andrew J. P.42; Folkersen, Lasse16; Witkowska, Kate9,43; Pers, Tune H.44,45,46,47; Joehanes, Roby48; Kim, Stuart K.49; Lataniotis, Lazaros14; Jansen, Rick50; Johnson, Andrew D.48,51; Warren, Helen9,43; Kim, Young Jin52; Zhao, Wei53; Wu, Ying54; Tayo, Bamidele O.55; Bochud, Murielle56,57; Absher, Devin58; Adair, Linda S.59; Amin, Najaf60; Arkingl, Dan E.1; Axelsson, Tomas61; Baldassarre, Damian62,63; Balkau, Beverley64; Bandinelli, Stefania65; Barnes, Michael R.14,43; Barroso, Ines66,67,68; Bevan, Stephen69; Bis, Joshua C.70; Bjornsdottir, Gyda11; Boehnke, Michael6,7; Boerwinkle, Eric71; Bonnycastle, Lori L.72; Boomsma, Dorret I.73; Bornstein, Stefan R.74; Brown, Morris J.75; Burnier, Michel76,57; Cabrera, Claudia P.9,43; Chambers, John C.77,78; Chang, I-Shou79; Cheng, Ching-Yu80,81,82,83; Chines, Peter S.72; Chung, Ren-Hua84; Collins, Francis S.72; Connell, John M.85; Doring, Angela86,87; Dallongeville, Jean88; Danesh, John66,89,90; de Faire, Ulf91; Delgado, Graciela29; Dominiczak, Anna F.92; Doney, Alex S. F.13; Drenos, Fotios42,93; Edkins, Sarah66; Eicher, John D.48,51; Elosua, Roberto94; Enroth, Stefan95,96; Erdmann, Jeanette97,98; Eriksson, Per16; Esko, Tonu44,99,100; Evangelou, Evangelos77,101; Evans, Alun21; Fai, Tove102; Farra, Martin3,103; Felixl, Janine F.104; Ferrieres, Jean105; Ferrucci, Luigi106; Fornage, Myriam107; Forrester, Terrence108; Franceschinil, Nora109; Franco, Oscar H.104; Franco-Cereceda, Anders110; Fraser, Ross M.111,112; Ganesh, Santhi K.113; Gao, He77; Gertow, Karl16,17; Gianfagna, Francesco114,115; Gigante, Bruna91; Giulianini, Franco4; Goe, Anuj3,103; Goodall, Alison H.116,117; Goodarzi, Mark118; Gorski, Mathias119,120; Grassler, Jurgen121; Groves, Christopher J.122; Gudnason, Vilmundur123,124; Gyllensten, Ulf95,96; Hallmans, Goran18; Hartikainen, Anna-Liisa125,126; Hassinen, Maija127; Havulinna, Aki S.26; Hayward, Caroline128; Hercberg, Serge129; Herzig, Karl-Heinz130,131,132,133; Hicks, Andrew A.134,135; Hingorani, Aroon D.28; Hirschhorn, Joel N.44,45,136,137; Hofmanl, Albert104,138; Holmen, Jostein139; Holmen, Oddgeir Lingaas139,140; Hottenga, Jouke-Jan73; Howard, Phil42; Hsiung, Chao A.84; Hunt, Steven C.141,142; Ikram, M. Arfan104,143,144; Illig, Thomas145,146; Iribarren, Carlos147; Jensen, Richard A.70,148; Kahonen, Mika149,150; Kang, Hyun Min6,7; Kathiresan, Sekar151,152,153; Keating, Brendan J.154,155; Khaw, Kay-Tee156; Kim, Yun Kyoung52; Kim, Eric30,31; Kivimaki, Mika28; Klopp, Norman145,157; Kolovou, Genovefa158; Komulainen, Pirjo127; Kooner, Jaspal S.159,78,160; Kosova, Gulum100,151,161; Krauss, Ronald M.162; Kuh, Diana163; Kutalik, Zoltan164,165,166; Kuusisto, Johanna167; Kvaloy, Kirsti139; Lakka, Timo A.127,168,169; Lee, Nanette R.170,171; Lee, I-Te172,173; Lee, Wen-Jane174; Levy, Daniel48,175; Li, Xiaohui30,31; Liang, Kae-Woei176,177; Lin, Honghuang48,178; Lin, Li2; Lindstrom, Jaana26; Lobbens, Stephane179,180,181; Mannisto, Satu26; Muller, Gabriele182; Muller-Nurasyid, Martina15,183,184; Mach, Francois2; Markus, Hugh S.185; Marouli, Eirini14,186; McCarthy, Mark I.3,122; McKenzie, Colin A.108; Meneton, Pierre187; Menni, Cristina188; Metspalu, Andres99; Mijatovic, Vladan189; Moilanen, Leena190,191; Montasser, May E.192; Morris, Andrew D.13; Morrison, Alanna C.193; Mulas, Antonella194; Nagaraja, Ramaiah22; Narisu, Narisu72; Nikus, Kjell195,196; O'Donnell, Christopher J.48,153,197; O'Reilly, Paul F.198; Ong, Ken K.12; Paccaud, Fred158; Palmer, Cameron D.44,136,199; Parsa, Afshin192; Pedersen, Nancy L.38; Penninx, Brenda W.200,201,202; Perola, Markus26,27,99; Peters, Annette87; Poulter, Neil203; Pramstaller, Peter P.134,135,204,205; Psaty, Bruce M.70,206,207,208; Quertermous, Thomas39; Rao, Dabeeru C.209; Rasheed, Asif210; Rayner, N. William3,66,122; Renstrom, Frida18,19,211; Rettig, Rainer212; Rice, Kenneth M.213; Roberts, Robert214,215; Rose, Lynda M.4; Rossouw, Jacques197; Samani, Nilesh J.116,117; Sanna, Serena194; Saramies, Jouko216; Schunkert, Heribert217,218,219; Sebert, Sylvain132,169,220; Sheu, Wayne H-H17,172,173,206; Shin, Young-Ah52; Sim, Xueling6,7,221,165; Smit, Johannes H.200; Smith, Albert V.123,124; Sosa, Maria X.1; Spector, Tim D.188; Stancakova, Alena222; Stanton, Alice V.223; Stirrups, Kathleen E.14,224,83; Stringham, Heather M.6,7; Sundstrom, Johan61; Swift, Amy J.72; Syvanen, Ann-Christine61; Tai, E-Shyong81,221,165,225; Tanaka, Toshiko106; Tarasov, Kirill V.226; Teumer, Alexander227; Thorsteinsdottir, Unnur11,124; Tobin, Martin D.228; Tremoli, Elena62,63; Uitterlinden, Andre G.104,229; Uusitupa, Matti230,231; Vaez, Ahmad37,232; Vaidya, Dhananjay233; van Duijn, Cornelia M.104,234; van Iperen, Erik P. A.235,236; Vasan, Ramachandran S.48,237,238; Verwoert, Germaine C.104; Virtamo, Jarmo26; Vitart, Veronique128; Voight, Benjamin F.239; Vollenweider, Peter240; Wagner, Aline241; Wain, Louise V.228; Wareham, Nicholas J.12; Watldns, Hugh3,103; Weder, Alan B.242; Westra, Harm Jan243; Wilks, Rainford244; Wilsgaard, Tom245,246; Wilson, James F.111,128; Wong, Tien Y.80,81,82,83; Yang, Tsun-Po14,247; Yao, Jie30,31; Yengo, Loic179,180,181; Zhang, Weihua77,159; Zhao, Jing Hua12; Zhu, Xiaofeng248; Bovet, Pascal56,57,249; Cooper, Richard S.55; Mohlke, Karen L.54; Saleheen, Danish210,250; Lee, Jong-Young52; Elliott, Paul77,251; Gierman, Hinco J.49,252; Willer, Cristen J.8,242; Franke, Lude; Hovingh, G. Kees; Taylor, Kent D.30,31; Dedoussis, George186; Sever, Peter203; Wong, Andrew163; Lind, Lars61; Assimes, Themistocles L.39; Njolstad, Inger245,246; Schwarz, Peter E. H.74,253,254,255; Langenberg, Claudia12; Snieder, Harold37; Caulfield, Mark J.9,43; Melander, E.34; Laakso, Markku167; Saltevo, Juha256; Rauramaa, Rainer127,169; Tuomilehto, Jaakko26,257,258,259; Ingelsson, Erik39,102; Lehtimaki, Terho32,33; Hveem, Kristian139; Palmas, Walter260; Marz, Winfried261,262; Kumar, Meena28; Salomaa, Veikko26; Chen, Yii-Der I.30,31; Rotter, Jerome I.30,31; Froguel, Philippe123,179,180,181; Jarvelin, Marjo-Riitta132,220,251,263; Lakatta, Edward G.226; Kuulasmaa, Kari26; Franks, Paul W.18,19,264; Hamsten, Anders16,17; Wichmann, H-Erich86,184,265; Palmer, Colin N. A.13; Stefansson, Kari11,124; Ridker, Paul M.4,5; Loos, Ruth J. F.12,266,267; Chalcravarti, Aravinda1; Deloukas, Panos14,268; Morris, Andrew P.3,269; Newton-Cheh, Christopher136,100,150,161; Munroe, Patricia B.9,43
Organizations: 1Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Ctr Complex Dis Genom, Baltimore, MD USA.
2Univ Hosp Geneva, Dept Med, Cardiol, Geneva, Switzerland.
3Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
4Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA.
5Harvard Med Sch, Boston, MA USA.
6Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.
7Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA.
8Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA.
9Queen Mary Univ London, William Harvey Res Inst, Clin Pharmacol, London, England.
10GlaxoSmithKline, Stevenage, Herts, England.
11deCODE Genet Amgen Inc, Reykjavik, Iceland.
12Univ Cambridge, Sch Clin Med, Inst Metab Sci, MRC Epidemiol Unit, Cambridge Biomed Campus, Cambridge, England.
13Univ Dundee, Ninewells Hosp & Med Sch, Med Res Inst, Dundee, Scotland.
14Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.
15Helmholtz Zentrum Munchen, Inst Genet Epidemiol, Neuherberg, Germany.
16Karolinska Inst, Dept Med, Cardiovasc Res Unit, Ctr Mol Med, Stockholm, Sweden.
17Karolinska Univ Hosp Solna, Ctr Mol Med, Stockholm, Sweden.
18Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.
19Lund Univ, Genet & Mol Epidemiol Unit, Dept Clin Sci, Malmo, Sweden.
20Umea Univ, Dept Odontol, Umea, Sweden.
21Queens Univ Belfast, Ctr Excellence Publ Hlth, Belfast, Antrim, North Ireland.
22NIA, Genet Lab, Intramural Res Program, US Natl Inst Hlth, Baltimore, MD 21224 USA.
23Imperial Coll London, Sch Publ Hlth, Hammersmith Hosp, Dept Genom Common Dis, London, England.
24INSERM UMR 970, Paris Cardiovasc Res Ctr PARCC, Paris, France.
25Univ Paris 05, Sorbonne Paris Cite, Paris, France.
26Natl Inst Hlth & Welf, Helsinki, Finland.
27Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland.
28UCL, Dept Epidemiol & Publ Hlth, Genet Epidemiol Grp, London, England.
29Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Mannheim, Germany.
30Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Los Angeles Biomed Res Inst, Torrance, CA 90509 USA.
31Harbor UCLA Med Ctr, Dept Pediat, Torrance, CA 90509 USA.
32Fimlab Labs, Dept Clin Chem, Tampere, Finland.
33Univ Tampere, Dept Clin Chem, Sch Med, Tampere, Finland.
34Lund Univ, Dept Internal Med, Malmo, Sweden.
35Univ Verona, Dept Med, Verona, Italy.
36Uppsala Univ, Uppsala Clin Res Ctr, Uppsala, Sweden.
37Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
38Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
39Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA.
40Univ Athens, Sch Med, Attikon Hosp, Dept Cardiol 2, Athens, Greece.
41Childrens Hosp Oakland Res Inst, Oakland, CA USA.
42UCL, Inst Cardiovasc Sci, Ctr Cardiovasc Genet, London, England.
43Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Unit, London, England.
44Boston Childrens Hosp, Div Endocrinol, Boston, MA USA.
45Boston Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA USA.
46Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Metab Sect, Genet,Fac Hlth & Med Sci, Copenhagen, Denmark.
47Statens Serum Inst, Dept Epidemiol Res, Copenhagen, Denmark.
48NHLBI, Framingham Heart Study, Framingham, MA USA.
49Stanford Univ, Med Ctr, Dept Dev Biol & Genet, Stanford, CA 94305 USA.
50Vrije Univ Amsterdam, Dept Psychiat, Med Ctr, Amsterdam, Netherlands.
51NHLBI, Cardiovasc Epidemiol & Human Genom Branch, Bldg 10, Bethesda, MD 20892 USA.
52Natl Inst Hlth, Ctr Genome Sci, Osong Hlth Technol Adm Complex, Chungcheongbuk Do, South Korea.
53Univ Penn, Dept Med, Div Translat Med & Human Genet, Philadelphia, PA 19104 USA.
54Univ N Carolina, Dept Genet, Chapel Hill, NC USA.
55Loyola Univ, Chicago Stritch Sch Med, Dept Publ Hlth Sci, Maywood, IL 60153 USA.
56CHU Vaudois, Inst Social & Prevent Med IUMSP, Lausanne, Switzerland.
57Univ Lausanne, Lausanne, Switzerland.
58HudsonAlpha Inst Biotechnol, Huntsville, AL USA.
59Univ N Carolina, Dept Nutr, Chapel Hill, NC USA.
60Erasmus MC, Dept Epidemiol, Genet Epidemiol Unit, Rotterdam, Netherlands.
61Uppsala Univ, Dept Med Sci, Uppsala, Sweden.
62Univ Milan, Dipartimento Sci Farmacol & Biomol, Milan, Italy.
63IRCCS, Ctr Cardiol Monzino, Milan, Italy.
64Univ Paris 11, Ctr Res Epidemiol & Populat Hlth, INSERM U1018, URMS 1018, Villejuif, France.
65ASF, Geriatr Unit, Florence, Italy.
66Wellcome Trust Sanger Inst, Wellcome Trust Genome Campus, Hinxton, England.
67Univ Cambridge, Inst Metab Sci, Addenbrookes Hosp, Metab Res Labs, Cambridge, England.
68Addenbrookes Hosp, NIHR Cambridge Biomed Res Ctr, Inst Metab Sci, Cambridge, England.
69Lincoln Univ, Joseph Banks Labs, Sch Life Sci, Lincoln, England.
70Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.
71Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Human Genet Ctr, Houston, TX 77030 USA.
72NHGRI, Med Genom & Metab Genet Branch, US Natl Inst Hlth, Bethesda, MD 20892 USA.
73Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands.
74Univ Dresden, Med Fac Carl Gustav Carus, Dept Med 3, Dresden, Germany.
75Queen Mary Univ London, Barts Heart Ctr, William Harvey Res Inst, London, England.
76CHU Vaudois, Nephrol, Lausanne, Switzerland.
77Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.
78Imperial Coll Healthcare NHS Trust, London, England.
79Natl Inst Canc Res, Natl Hlth Res Inst, Zhunan Town, Taiwan.
80Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore.
81Duke NUS Grad Med Sch Singapore, Singapore, Singapore.
82Natl Univ Singapore, Dept Ophthalmol, Singapore, Singapore.
83Natl Univ Hlth Syst, Singapore, Singapore.
84Natl Hlth Res Inst, Div Biostat & Bioinformat, Inst Populat Hlth Sci, Zhunan Town, Taiwan.
85Univ Dundee, Ninewells Hosp & Med Sch, Dundee, Scotland.
86Helmholtz Zentrum Munchen, Inst Epidemiol 1, Neuherberg, Germany.
87Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.
88Univ Lille 2, INSERM UMR 1167, Inst Pasteur Lille, Lille, France.
89Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.
90Univ Cambridge, Dept Publ Hlth & Primary Care, NIHR Blood & Transplant Res Unit Donor Hlth & Gen, Cambridge, England.
91Karolinska Inst, Inst Environm Med, Div Cardiovasc Epidemiol, Stockholm, Sweden.
92Univ Glasgow, Inst Cardiovasc & Med Sci, BHF Glasgow Cardiovasc Res Ctr, Glasgow, Lanark, Scotland.
93Univ Bristol, Sch Social & Community Med, Med Res Council Integrat Epidemiol Unit, Oakfield House, Bristol, Avon, England.
94Inst Hosp Mar Invest Med IMIM, Cardiovasc Epidemiol & Genet, Barcelona, Spain.
95Uppsala Univ, Dept Immunol Genet & Pathol, Biomed Ctr, Uppsala, Sweden.
96Uppsala Univ, Biomed Ctr, Sci Life Lab, Uppsala, Sweden.
97Univ Lubeck, Inst Integrat & Expt Genom, Lubeck, Germany.
98Deutsch Zentrum Herz Kreislauf Forsch DZHK, Partner Site Hamburg, Kiel, Germany.
99Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.
100Broad Inst MIT & Harvard, Cambridge, MA USA.
101Univ Ioannina, Dept Hyg & Epidemiol, Sch Med, Ioannina, Greece.
102Uppsala Univ, Mol Epidemiol & Sci Life Lab, Dept Med Sci, Uppsala, Sweden.
103Univ Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford, England.
104Erasmus MC, Univ Med Ctr Rotterdam, Dept Epidemiol, Rotterdam, Netherlands.
105Toulouse Univ, Sch Med, Rangueil Univ Hosp, INSERM UMR 1027, Toulouse, France.
106NIA, Translat Gerontol Branch, Baltimore, MD 21224 USA.
107Univ Texas Hlth Sci Ctr Houston, Inst Mol Med, Houston, TX 77030 USA.
108Univ West Indies, Trop Metab Res Unit, Res Inst Trop Med, Kingston, Jamaica.
109Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA.
110Karolinska Inst, Dept Mol Med & Surg, Cardiothorac Surg Unit, Stockholm, Sweden.
111Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland.
112Synpromics Ltd, Edinburgh, Midlothian, Scotland.
113Univ Michigan, Sch Med, Dept Cardiol, Ann Arbor, MI 48109 USA.
114Univ Insubria, Dept Clin & Expt Med, Epidemiol & Prevent Med EPIMED Res Ctr, Varese, Italy.
115IRCCS, Ist Neurol Mediterraneo NEUROMED, Dept Epidemiol & Prevent, Pozzilli, Italy.
116Univ Leicester, Glenfield Hosp, Dept Cardiovasc Sci, Leicester, Leics, England.
117Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England.
118Cedars Sinai Med Ctr, Div Endocrinol Diabet & Metab, Los Angeles, CA 90048 USA.
119Univ Regensburg, Inst Epidemiol & Prevent Med, Dept Genet Epidemiol, Regensburg, Germany.
120Univ Hosp Regensburg, Dept Nephrol, Regensburg, Germany.
121Tech Univ Dresden, Dept Med 2, Div Pathobiochem, Dresden, Germany.
122Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.
123Iceland Heart Assoc, Kopavogur, Iceland.
124Univ Iceland, Fac Med, Reykjavik, Iceland.
125Univ Oulu, Inst Clin Med Obstet & Gynaecol, Oulu, Finland.
126Oulu Univ Hosp, Med Res Ctr, Oulu, Finland.
127Kuopio Res Inst Exercise Med, Kuopio, Finland.
128Western Gen Hosp, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.
129Univ Paris 13, UREN, INSERM U557, INRA U1125,Sorbonne Paris Cite, Bobigny, France.
130Univ Oulu, Inst Biomed, Med Res Ctr Oulu, Oulu, Finland.
131Oulu Univ Hosp, Oulu, Finland.
132Univ Oulu, Bioctr Oulu, Oulu, Finland.
133Poznan Univ Med Sci, Dept Gastroenterol & Metab, Poznan, Poland.
134European Acad Bozen Bolzano EURAC, Ctr Biomed, Bolzano, Italy.
135Univ Lubeck, Inst, Lubeck, Germany.
136Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA USA.
137Harvard Med Sch, Dept Genet, Boston, MA USA.
138Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
139Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, HUNT Res Ctr, Levanger, Norway.
140Univ Trondheim Hosp, St Olav Hosp, Trondheim, Norway.
141Univ Utah, Sch Med, Cardiovasc Genet Div, Salt Lake City, UT USA.
142Weill Cornell Med Coll Qatar, Dept Genet Med, Doha, Qatar.
143Erasmus MC, Dept Radiol, Rotterdam, Netherlands.
144Erasmus MC, Univ Med Ctr Rotterdam, Dept Neurol, Rotterdam, Netherlands.
145Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany.
146Hannover Med Sch, Inst Human Genet, Hannover, Germany.
147Kaiser Permanente, Div Res, Oakland, CA USA.
148Univ Tampere, Sch Med, Dept Clin Physiol, Tampere, Finland.
149Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA USA.
150Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.
151Harvard Med Sch, Dept Med, Boston, MA USA.
152Univ Penn, Dept Surg, Div Transplantat, Philadelphia, PA 19104 USA.
153Univ Penn, Dept Pediat, Philadelphia, PA 19104 USA.
154Univ Cambridge, Inst Publ Hlth, Dept Publ Hlth & Primary Care, Cambridge, England.
155Onassis Cardiac Surg Ctr, Dept Cardiol 1, Athens, Greece.
156Imperial Coll London, Hammersmith Hosp Campus, Natl Heart & Lung Inst, London, England.
157Hannover Med Sch, Hannover Unified Biobank, Hannover, Germany.
158Childrens Hosp Oakland, Res Inst, Dept Med, Oakland, CA 94609 USA.
159Ealing Hosp NHS Trust, Dept Cardiol, Southall, Middx, England.
160MRC Unit Lifelong Hlth & Ageing UCL, London, England.
161Massachusetts Gen Hosp, Div Cardiol, Dept Med, Boston, MA 02114 USA.
162Univ Lausanne, Dept Med Genet, Lausanne, Switzerland.
163Swiss Inst Bioinformat, Lausanne, Switzerland.
164Univ Eastern Finland, Dept Med, Kuopio, Finland.
165Kuopio Univ Hosp, Kuopio, Finland.
166Univ Eastern Finland, Inst Biomed Physiol, Kuopio, Finland.
167Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, Kuopio, Finland.
168Off Populat Studies Fdn Inc, Cebu, Philippines.
169Univ San Carlos, Dept Anthropol Sociol & Hist, Cebu, Philippines.
170Taichung Vet Gen Hosp, Dept Internal Med, Div Endocrine & Metab, Taichung, Taiwan.
171Natl Yang Ming Univ, Sch Med, Taipei, Taiwan.
172Taichung Vet Gen Hosp, Dept Med Res, Taichung, Taiwan.
173NHLBI, Populat Sci Branch, US Natl Inst Hlth, Bldg 10, Bethesda, MD 20892 USA.
174Taichung Vet Gen Hosp, Cardiovasc Ctr, Taichung, Taiwan.
175Natl Yang Ming Univ, Inst Clin Med, Sch Med, Taipei, Taiwan.
176Boston Univ, Sch Med, Sect Computat Biomed, Dept Med, Boston, MA 02215 USA.
177EGID, Lille, France.
178Lille Pasteur Inst, CNRS UMR 8199, Lille, France.
179Univ Lille 2, Lille, France.
180Univ Dresden, Med Fac Carl Gustav Carus, Ctr Evidence Based Healthcare, Dresden, Germany.
181Univ Munich, Univ Hosp Grosshadern, Dept Med 1, Munich, Germany.
182Univ Munich, Inst Med Informat Biometry & Epidemiol, Munich, Germany.
183Univ Cambridge, Neurol Unit, Biomed Campus, Cambridge, England.
184Harokopio Univ, Dept Dietet Nutr, Athens, Greece.
185Univ Paris 13, Univ Paris 06, Sorbonne Univ, INSERM U1142,LIMICS,UMRS 1142, Paris, France.
186Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England.
187Univ Verona, Dept Life & Reprod Sci, Verona, Italy.
188Kuopio Univ Hosp, Dept Med, Kuopio, Finland.
189Oulu Univ Hosp, Unit Gen Practice, Oulu, Finland.
190Univ Maryland, Sch Med, Dept Med, Program Personalized & Genom Med, Baltimore, MD 21201 USA.
191Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Houston, TX 77030 USA.
192Cittadella Univ Monseratto, IRGB, CNR, Cagliari, Italy.
193Tampere Univ Hosp, Ctr Heart, Dept Cardiol, Tampere, Finland.
194Univ Tampere, Sch Med, Dept Cardiol, Tampere, Finland.
195NHLBI, Div Cardiovasc Sci, Bldg 10, Bethesda, MD 20892 USA.
196Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England.
197Childrens Hosp Boston, Genet & Program Genom, Boston, MA USA.
198Vrije Univ Amsterdam, Dept Psychiat, EMGO Inst, Med Ctr, Neurosci Campus, Amsterdam, Netherlands.
199Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands.
200Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.
201Imperial Coll London, Int Ctr Circulatory Hlth, London, England.
202Gen Cent Hosp, Dept Neurol, Bolzano, Italy.
203Univ Lubeck, Dept Neurol, Lubeck, Germany.
204Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
205Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA.
206Grp Hlth Res Inst, Grp Hlth Cooperat, Seattle, WA USA.
207Washington Univ, Sch Med, Div Biostat, St Louis, MO USA.
208Ctr Noncommunicable Dis, Karachi, Pakistan.
209Umea Univ, Dept Biobank Res, Umea, Sweden.
210Univ Med Greifswald, Inst Physiol, Greifswald, Germany.
211Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
212Univ Ottawa, Inst Heart, Cardiovasc Res Methods Ctr Ontario, Ottawa, ON, Canada.
213Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada.
214South Karelia Cent Hosp, Lappeenranta, Finland.
215Deutsch Herzzentrum Munich, Munich, Germany.
216Tech Univ Munich, Munich, Germany.
217Deutsch Zentrum Herz Kreislauf Forsch DZHK, Munich, Germany.
218Munich Heart Alliance, Munich, Germany.
219Univ Oulu, Ctr Lifecourse Hlth Res, Oulu, Finland.
220Natl Def Med Ctr, Coll Med, Taipei, Taiwan.
221Univ Eastern Finland, Kuopio, Finland.
222Royal Coll Surgeons Ireland, Mol & Cellular Therapeut, Dublin, Ireland.
223Univ Cambridge, Dept Haematol, Cambridge, England.
224Natl Univ Singapore, Dept Med, Singapore, Singapore.
225NIA, Intramural Res Program, Lab Cardiovasc Sci, US Natl Inst Hlth, Baltimore, MD 21224 USA.
226Univ Med Greifswald, Inst Community Med, Greifswald, Germany.
227Univ Leicester, Dept Hlth Sci, Leicester, Leics, England.
228Erasmus MC, Dept Internal Med, Rotterdam, Netherlands.
229Univ Eastern Finland, Dept Publ Hlth & Clin Nutr, Kuopio, Finland.
230Kuopio Univ Hosp, Res Unit, Kuopio, Finland.
231Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommunicable Dis, Esfahan, Iran.
232Johns Hopkins Med Inst, Baltimore, MD 21205 USA.
233NGI Erasmus Med Ctr, Ctr Med Syst Biol CMSB 12, Rotterdam, Netherlands.
234Acad Med Ctr, Dept Clin Epidemiol Biostat & Bioinformat, Amsterdam, Netherlands.
235ICIN Netherlands Heart Inst, Durrer Ctr Cardiogenet Res, Utrecht, Netherlands.
236Boston Univ, Dept Med, Sect Prevent Med, Sch Med, Boston, MA USA.
237Boston Univ, Sch Med, Dept Med, Cardiol, Boston, MA 02215 USA.
238Univ Penn, Perelman Sch Med, Dept Genet, Dept Syst Pharmacol & Translat Therapeut, Philadelphia, PA 19104 USA.
239Univ Lausanne Hosp, Dept Internal Med, Lausanne, Switzerland.
240Univ Strasbourg, EA3430, Dept Epidemiol & Publ Hlth, Strasbourg, France.
241Univ Michigan, Sch Med, Div Cardiovasc Med, Dept Internal Med, Ann Arbor, MI 48109 USA.
242Univ Groningen, Univ Med Ctr Groningen, Groningen, Netherlands.
243Univ West Indies, Res Inst Trop Med, Epidemiol Res Unit, Kingston, Jamaica.
244Univ Tromso, Dept Community Med, Fac Hlth Sci, Tromso, Norway.
245Univ Tromso, Fac Hlth Sci, Dept Clin Med, Tromso, Norway.
246Univ Cambridge, MRC Canc Unit, Cambridge, England.
247Case Western Reserve Univ, Dept Epidemiol & Biostat, Sch Med, Cleveland, OH 44106 USA.
248Minist Hlth, Victoria, Seychelles.
249Univ Penn, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA.
250Imperial Coll London, Sch Publ Hlth, MRC PHE Ctr Environm & Hlth, London, England.
251Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands.
252Acad Med Ctr, Dept Vasc Med, Amsterdam, Netherlands.
253Univ Hosp, Paul Langerhans Inst Dresden, Helmholtz Ctr Munich, Dresden, Germany.
254Tech Univ Dresden, Fac Med, Dresden, Germany.
255German Ctr Diabet Res DZD, Neuherberg, Germany.
256Cent Finland Hlth Care Dist, Dept Med, Jyvaskyla, Finland.
257Dasman Diabet Inst, Dasman, Kuwait.
258King Abdulaziz Univ, Saudi Diabet Res Grp, Jeddah, Saudi Arabia.
259Danube Univ Krems, Ctr Vasc Prevent, Krems, Austria.
260Columbia Univ, Dept Med, New York, NY USA.
261Synlab Acad, Synlab Serv, Mannheim, Germany.
262Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Graz, Austria.
263Oulu Univ Hosp, Unit Primary Care, Oulu, Finland.
264Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
265Tech Univ Munich, Inst Med Stat & Epidemiol, Munich, Germany.
266Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.
267Icahn Sch Med Mt Sinai, Mindich Child Hlth Dev Inst, New York, NY 10029 USA.
268King Abdulaziz Univ, Princess Al Jawhara Al Brahim Ctr Excellence Res, Jeddah, Saudi Arabia.
269Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England.
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 1.1 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2019050714611
Language: English
Published: Springer Nature, 2016
Publish Date: 2019-05-07
Description:

Abstract

To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure–associated loci, of which 17 were new; 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target organ damage in multiple tissues but with minor effects in the kidney. Our findings expand current knowledge of blood pressure–related pathways and highlight tissues beyond the classical renal system in blood pressure regulation.

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Series: Nature genetics
ISSN: 1061-4036
ISSN-E: 1546-1718
ISSN-L: 1061-4036
Volume: 48
Issue: 10
Pages: 1171 - 1184
DOI: 10.1038/ng.3667
OADOI: https://oadoi.org/10.1038/ng.3667
Type of Publication: A1 Journal article – refereed
Field of Science: 3141 Health care science
Subjects:
EU Grant Number: (633595) DYNAHEALTH - Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging
Copyright information: © 2016 Nature America Inc., part of Springer Nature. All rights reserved. This is a post-peer-review, pre-copyedit version of an article published in Nature Genetics. The final authenticated version is available online at: http://dx.doi.org/10.1038/ng.3667