University of Oulu

Verdejo-Román, J., Björnholm, L., Muetzel, R.L. et al. Maternal prepregnancy body mass index and offspring white matter microstructure: results from three birth cohorts. Int J Obes 43, 1995–2006 (2019) doi:10.1038/s41366-018-0268-x

Maternal prepregnancy body mass index and offspring white matter microstructure : results from three birth cohorts

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Author: Verdejo-Román, Juan1; Björnholm, Lassi2,3,4; Muetzel, Ryan L.5,6,7;
Organizations: 1Mind, Brain and Behavior Research Center (CIMCYC), University of Granada, Granada, Spain
2The Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, Oulu, Finland
3Department of Psychiatry, Oulu University Hospital, Oulu, Finland
4Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
5The Department of Child and Adolescent Psychiatry, Erasmus MC, Sophia Children’s Hospital, Rotterdam, 3000 CB, The Netherlands
6The Generation R Study Group, Erasmus MC, Rotterdam, 3000 CA, The Netherlands
7The Department of Epidemiology, Erasmus MC, Rotterdam, 3000 CA, The Netherlands
8EURISTIKOS, Excellence Center for Pediatric Research, University of Granada, Granada, Spain
9The Department of Pediatrics, School of Medicine, University of Granada, Granada, Spain
10The Department of Pediatrics, Erasmus MC, Sophia Children’s Hospital, Rotterdam, 3000 CB, The Netherlands
11Department of Oncology and Radiotherapy, Oulu University Hospital, Oulu, Finland
12Institute of Diagnostics, Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
13Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland
14Biocenter Oulu, University of Oulu, Oulu, Finland
15Unit of Primary Health Care, Oulu University Hospital, Oulu, Finland
16Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK
17Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK
18The Department of Social and Behavioral Science, Harvard TH Chan School of Public Health, Boston, MA, USA
19Department of Psychology, Education & Child Studies, Erasmus University Rotterdam, Rotterdam, The Netherlands
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.3 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2019050714612
Language: English
Published: Springer Nature, 2019
Publish Date: 2019-06-05
Description:

Abstract

Background and aims: Prepregnancy maternal obesity is a global health problem and has been associated with offspring metabolic and mental ill-health. However, there is a knowledge gap in understanding potential neurobiological factors related to these associations. This study explored the relation between maternal prepregnancy body mass index (BMI) and offspring brain white matter microstructure at the age of 6, 10, and 26 years in three independent cohorts.

Subjects and methods: The study used data from three European birth cohorts (n = 116 children aged 6 years, n = 2466 children aged 10 years, and n = 437 young adults aged 26 years). Information on maternal prepregnancy BMI was obtained before or during pregnancy and offspring brain white matter microstructure was measured at age 6, 10, or 26 years. We used magnetic resonance imaging-derived fractional anisotropy (FA) and mean diffusivity (MD) as measures of white matter microstructure in the brainstem, callosal, limbic, association, and projection tracts. Linear regressions were fitted to examine the association of maternal BMI and offspring white matter microstructure, adjusting for several socioeconomic and lifestyle-related confounders, including education, smoking, and alcohol use.

Results: Maternal BMI was associated with higher FA and lower MD in multiple brain tracts, for example, association and projection fibers, in offspring aged 10 and 26 years, but not at 6 years. In each cohort maternal BMI was related to different white matter tract and thus no common associations across the cohorts were found.

Conclusions: Maternal BMI was associated with higher FA and lower MD in multiple brain tracts in offspring aged 10 and 26 years, but not at 6 years of age. Future studies should examine whether our observations can be replicated and explore the potential causal nature of the findings.

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Series: International journal of obesity
ISSN: 0307-0565
ISSN-E: 1476-5497
ISSN-L: 0307-0565
Volume: 43
Pages: 1995 - 2006
DOI: 10.1038/s41366-018-0268-x
OADOI: https://oadoi.org/10.1038/s41366-018-0268-x
Type of Publication: A1 Journal article – refereed
Field of Science: 3142 Public health care science, environmental and occupational health
Subjects:
Funding: This work was supported by the European Union's Horizon 2020 research and innovation program [grant agreement No.633595 DynaHEALTH] and No.733206 LifeCycle], the Netherlands Organization for Health Research and Development [ZONMW Vici project 016.VICI.170.200]. The PREOBE cohort was funded by Spanish Ministry of Innovation and Science. Junta de Andalucía: Excellence Projects (P06-CTS-02341) and Spanish Ministry of Economy and Competitiveness (BFU2012-40254-C03-01). The first phase of the Generation R Study is made possible by financial support from the Erasmus Medical Centre, the Erasmus University, and the Netherlands Organization for Health Research and Development (ZonMW, grant ZonMW Geestkracht 10.000.1003).
EU Grant Number: (633595) DYNAHEALTH - Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging
(733206) LIFECYCLE - Early-life stressors and LifeCycle health
Copyright information: © 2018, Springer Nature. This is a post-peer-review, pre-copyedit version of an article published in International Journal of Obesity. The final authenticated version is available online at: https://doi.org/10.1038/s41366-018-0268-x.