University of Oulu

Palaniswamy et al. Vitamin d and the Promotion of long-term Metabolic health from a Programming Perspective. Nutrition and Metabolic Insights 2015:8(s1) 11–21 doi:10.4137/NMi.s29526

Vitamin D and the promotion of long-term metabolic health from a programming perspective

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Author: Palaniswamy, Saranya1,2; Williams, Dylan3; Järvelin, Marjo-Riitta1,2,3,4,5;
Organizations: 1Center for Life-Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland
2Biocenter Oulu, Faculty of Medicine, University of Oulu, Oulu, Finland
3Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK
4MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College, London, UK
5Unit of Primary Care, Oulu University Hospital, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.5 MB)
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Language: English
Published: Libertas Academica, 2015
Publish Date: 2019-05-09


Studies linking vitamin D and long-term metabolic health have generated much debate. Recommendations for the intake of vitamin D by the general public and by the health care professionals have been complicated by a number of inconsistencies in the literature. These caveats relate to the methodological approaches, differences in the populations (and the species) of study, and the definitions used for thresholds of vitamin D status. This review addresses current evidence available for assessing the potential programming of long-term metabolic health of offspring by maternal vitamin D status in pregnancy. It summarizes knowledge on the early origins of metabolic health and analyzes evidence for an association between the vitamin D status in pregnancy and maternal and fetal health status. In addition, we analyze the link between the regulation of inflammation and the vitamin D status in the general population to inform on the general mechanisms through which early vitamin D might affect the programming of long-term health. The evidence suggests an association between the vitamin D status in early life and the programming of long-term health. However, to the best of our knowledge, the current finding is insufficient to draw a final conclusion for evidence-based preventive actions. The data warrant replication in prospective studies and additional research substantiating the causal factors and pathways.

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Series: Nutrition and metabolic insights
ISSN: 1178-6388
ISSN-E: 1178-6388
ISSN-L: 1178-6388
Volume: 8
Issue: 1
Pages: 11 - 21
DOI: 10.4137/NMI.S29526
Type of Publication: A1 Journal article – refereed
Field of Science: 3142 Public health care science, environmental and occupational health
Funding: The authors are thankful to the Academy of Finland, Biocenter Oulu, and the European Commission (Grant DynaHEALTH-H2020-633595) for funding their research. The authors confirm that the funder had no influence over the study design, content of the article, or selection of this journal.
EU Grant Number: (633595) DYNAHEALTH - Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging
Copyright information: © the authors, publisher and licensee Libertas Academica Limited. This is an open-access article distributed under the terms of the creative commons CC-BY-NC 3.0 license.