University of Oulu

Ried, J. S. et al. A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. Nat. Commun. 7, 13357 doi: 10.1038/ncomms13357 (2016).

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

Saved in:
Author: Ried, Janina S.1; Jeff, Janina M.2; Chu, Audrey Y.3;
Bragg-Gresham, Jennifer L.4; van Dongen, Jenny5; Huffman, Jennifer E.6; Ahluwalia, Tarunveer S.7,8,9; Cadby, Gemma10; Eklund, Niina; Eriksson, Joel11; Esko, Tonu12,13,14,15; Feitosa, Mary F.; Goel, Anuj16,17; Gorski, Mathias18,19; Hayward, Caroline6; Heard-Costa, Nancy L.20,21; Jackson, Anne U.22; Jokinen, Eero23; Kanoni, Stavroula24,25; Kristiansson, Kati26,27; Kutalik, Zoltan28,29,30; Lahti, Jari31,32; Luan, Jian'an33; Maegi, Reedik14,17; Mahajan, Anubha17; Mangino, Massimo34; Medina-Gomez, Carolina35,36; Monda, Keri L.37,38; Nolte, Ilja M.; Perusse, Louis39,40; Prokopenko, Inga17,41,42,43; Qi, Lu44,45; Rose, Lynda M.3; Salvi, Erika46,47; Smith, Megan T.48; Snieder, Harold; Stancakova, Alena49; Sung, Yun Ju50; Tachmazidou, Ioanna24; Teumer, Alexander51,52; Thorleifsson, Gudmar53; van der Harst, Pim54,55,56; Walker, Ryan W.2,57; Wang, Sophie R.15,58,59,60; Wild, Sarah H.61; Willems, Sara M.62; Wong, Andrew63; Zhang, Weihua64,65; Albrecht, Eva1; Alves, Alexessander Couto66; Bakker, Stephan J. L.67; Barlassina, Cristina46,47; Bartz, Traci M.48,68,69; Beilby, John70,71; Bellis, Claire72,73; Bergman, Richard N.74; Bergmann, Sven28,29; Blangero, John75; Blueher, Matthias76,77; Boerwinkle, Eric; Bonnycastle, Lori L.78; Bornstein, Stefan R.79; Bruinenberg, Marcel80; Campbell, Harry61; Chen, Yii-Der Ida81; Chiang, Charleston W. K.; Chines, Peter S.78; Collins, Francis S.78; Cucca, Fracensco82; Cupples, L. Adrienne20; D'Avila, Francesca46,47; de Geus, Eco J. C.5,83; Dedoussis, George84; Dimitriou, Maria24,84; Doering, Angela85,86; Eriksson, Johan G.31,87,88; Farmaki, Aliki-Eleni84; Farrall, Martin16,17; Ferreira, Teresa17; Fischer, Krista14; Forouhi, Nita G.33; Friedrich, Nele89; Gjesing, Anette Prior7; Glorioso, Nicola90; Graff, Mariaelisa37; Grallert, Harald86,91,92; Grarup, Niels7; Graessler, Juergen93; Grewal, Jagvir64,65; Hamsten, Anders94,95,96; Harder, Marie Neergaard7; Hartman, Catharina A.97; Hassinen, Maija98; Hastie, Nicholas6; Hattersley, Andrew Tym99; Havulinna, Aki S.26; Heliovaara, Markku26; Hillege, Hans56; Hofman, Albert35; Holmen, Oddgeir100; Homuth, Georg52; Hottenga, Jouke-Jan5; Hui, Jennie70,71,101; Husemoen, Lise Lotte102; Hysi, Pirro G.34; Isaacs, Aaron62; Ittermann, Till51; Jalilzadeh, Shapour16,17; James, Alan L.103; Jorgensen, Torben104,105,106; Jousilahti, Pekka26; Jula, Antti26; Justesen, Johanne Marie7; Justice, Anne E.37; Kahonen, Mika107,108; Karaleftheri, Maria109; Khaw, Kay Tee110; Keinänen-Kiukaanniemi, Sirkka M.111,112; Kinnunen, Leena113; Knekt, Paul B.26; Koistinen, Heikki A.113,114,115; Kolcic, Ivana116; Kooner, Ishminder K.65; Koskinen, Seppo26; Kovacs, Peter76; Kyriakou, Theodosios16,17; Laitinen, Tomi117,118; Langenberg, Claudia33,119; Lewin, Alexandra M.66; Lichtner, Peter120; Lindgren, Cecilia M.12,17,121; Lindstrom, Jaana26; Linneberg, Allan102,104,122; Lorbeer, Roberto51; Lorentzon, Mattias11; Luben, Robert123; Lyssenko, Valeriya8,124,125; Mannisto, Satu26; Manunta, Paolo11,126,127; Leach, Irene Mateo56; McArdle, Wendy L.128; Mcknight, Barbara48,69,129; Mohlke, Karen L.130; Mihailov, Evelin14; Milani, Lili14; Mills, Rebecca65; Montasser, May E.131; Morris, Andrew P.17,132; Mueller, Gabriele133; Musk, Arthur W.134; Narisu, Narisu78; Ong, Ken K.33,63,135; Oostra, Ben A.62; Osmond, Clive136; Palotie, Aarno27,137; Pankow, James S.138; Paternoster, Lavinia139; Penninx, Brenda W.140,141; Pichler, Irene142,143; Pilia, Maria G.144; Polasek, Ozren61,116; Pramstaller, Peter P.142,143,145,146; Raitakari, Olli T.147,148; Rankinen, Tuomo149; Rao, D. C.49,50; Rayner, Nigel W.17,43,150; Ribel-Madsen, Rasmus7; Rice, Treva K.50,151; Richards, Marcus43,63; Ridker, Paul M.3,152; Rivadeneira, Fernando35,36; Ryan, Kathy A.131; Sanna, Serena144; Sarzynski, Mark A.149; Scholtens, Salome; Scott, Robert A.33; Sebert, Sylvain41,42,153,154; Southam, Lorraine17,24; Sparso, Thomas Hempel7; Steinthorsdottir, Valgerdur53; Stirrups, Kathleen24,25; Stolk, Ronald P.; Strauch, Konstantin1,155; Stringham, Heather M.22; Swertz, Morris A.55; Swift, Amy J.78; Toenjes, Anke77; Tsafantakis, Emmanouil156; van der Most, Peter J.; Van Vliet-Ostaptchouk, Jana V.157; Vandenput, Liesbeth11; Vartiainen, Erkki26; Venturini, Cristina34,158; Verweij, Niek56; Viikari, Jorma S.159,160; Vitart, Veronique6; Vohl, Marie-Claude40,161; Vonk, Judith M.; Waeber, Gerard162,163; Widen, Elisabeth27; Willemsen, Gonneke5; Wilsgaard, Tom164; Winkler, Thomas W.19; Wright, Alan F.6; Yerges-Armstrong, Laura M.131; Zhao, Jing Hua33; Zillikens, M. Carola36; Boomsma, Dorret I.5; Bouchard, Claude149; Chambers, John C.64,65,165; Chasman, Daniel I.3,152; Cusi, Daniele46,47; Gansevoort, Ron T.67; Gieger, Christian1,86,92; Hansen, Torben7,166; Hicks, Andrew A.142,143; Hu, Frank44,45; Hveem, Kristian100; Jarvelin, Marjo-Riitta153,167,168; Kajantie, Eero26,87,169,170,171,172; Kooner, Jaspal S.65,165,173; Kuh, Diana63; Kuusisto, Johanna49; Laakso, Markku49; Lakka, Timo A.98,174; Lehtimaeki, Terho175,176,177; Metspalu, Andres14; Njolstad, Inger164,178; Ohlsson, Claes11; Oldehinkel, Albertine J.97; Palmer, Lyle J.179,180; Pedersen, Oluf7; Perola, Markus26,14,27; Peters, Annette86,92,181; Psaty, Bruce M.69,182,183,184; Puolijoki, Hannu185; Rauramaa, Rainer98,186; Rudan, Igor61; Salomaa, Veikko26; Schwarz, Peter E. H.79,187; Shudiner, Alan R.131,188; Smit, Jan H.140,141; Sorensen, Thorkild I. A.7,189,190; Spector, Timothy D.34; Stefansson, Kari53,191; Stumvoll, Michael76,77; Tremblay, Angelo39; Tuomilehto, Jaakko68,192,193,194; Uitterlinden, Andre G.35,36; Uusitupa, Matti195,196; Voelker, Uwe52,197; Vollenweider, Peter162,163; Wareham, Nicholas J.33; Watkins, Hugh16,17; Wilson, James F.6,61; Zeggini, Eleftheria24; Abecasis, Goncalo R.22; Boehnke, Michael22; Borecki, Ingrid B.; Deloukas, Panos25,150,198; van Duijn, Cornelia M.62,199; Fox, Caroline20,152; Groop, Leif C.124,125,200; Heid, Iris M.19,201; Hunter, David J.12,44,45,202; Kaplan, Robert C.203; McCarthy, Mark I.17,43,204; North, Kari E.205; O'Connell, Jeffrey R.131; Schlessinger, David206; Thorsteinsdottir, Unnur53,191; Strachan, David P.207; Frayling, Timothy208; Hirschhorn, Joel N.12,13,15,58,59,60,209; Mueller-Nurasyid, Martina1,155,181,210; Loos, Ruth J. F.2,33,57,211,212
Organizations: 1Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, D-85764 Neuherberg, Germany.
2Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.
3Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02215 USA.
4Univ Michigan, Kidney Epidemiol & Cost Ctr Internal Med Nephrol, Ann Arbor, MI 48109 USA.
5Vrije Univ Amsterdam, Dept Biol Psychol, NL-1081 BT Amsterdam, Netherlands.
6Univ Edinburgh, MRC Human Genet Unit Inst Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland.
7Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Sect Metab Genet, DK-2100 Copenhagen, Denmark.
8Steno Diabet Ctr A S, DK-2820 Gentofte, Denmark.
9Univ Copenhagen, Herlev & Gentofte Hosp, Copenhagen Prospect Studies Asthma Childhood, COPSAC, Ledreborg Alle 34, DK-2820 Copenhagen, Denmark.
10Univ Western Australia, Ctr Genet Origins Hlth & Dis, Crawley, WA 6009, Australia.
11Univ Gothenburg, Sahlgrenska Acad, Ctr Bone & Arthrit Res Inst Med, Dept Internal Med & Clin Nutr, S-41345 Gothenburg, Sweden.
12Harvard Univ, Broad Inst, Cambridge, MA 2142 USA.
13Boston Childrens Hosp, Ctr Basic & Translat Obes Res, Div Endocrinol & Genet, Boston, MA 02115 USA.
14Univ Tartu, Estonian Genome Ctr, EE-51010 Tartu, Estonia.
15Harvard Med Sch, Dept Genet, Boston, MA 02115 USA.
16Univ Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford OX3 9DU, England.
17Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England.
18Univ Hosp Regensburg, Dept Nephrol, D-93042 Regensburg, Germany.
19Univ Regensburg, Inst Epidemiol & Prevent Med, Dept Genet Epidemiol, D-93053 Regensburg, Germany.
20NHLBI, Framingham Heart Study, Framingham, MA 01702 USA.
21Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA.
22Univ Michigan, Ctr Stat Genet, Dept Biostat, Ann Arbor, MI 48109 USA.
23Univ Helsinki, Hosp Children & Adolescents, FI-00290 Helsinki, Finland.
24Human Genet, Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England.
25Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London EC1M 6BQ, England.
26Natl Inst Hlth & Welf THL, Dept Hlth, FI-00271 Helsinki, Finland.
27Univ Helsinki, Inst Mol Med Finland, FI-00290 Helsinki, Finland.
28Swiss Inst Bioinformat, CH-1015 Lausanne, Switzerland.
29Univ Lausanne, Dept Med Genet, CH-1005 Lausanne, Switzerland.
30Univ Hosp Lausanne CHUV, Inst Social & Prevent Med, CH-1010 Lausanne, Switzerland.
31Folkhalsan Res Ctr, FI-00290 Helsinki, Finland.
32Univ Helsinki, Inst Behav Sci, FI-00014 Helsinki, Finland.
33Univ Cambridge, Inst Metab Sci, Sch Clin Med, MRC Epidemiol Unit, Cambridge Biomed Campus, Cambridge CB2 0QQ, England.
34Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England.
35Erasmus MC, Dept Epidemiol, NL-3015 GE Rotterdam, Netherlands.
36Erasmus MC, Dept Internal Med, NL-3015 GE Rotterdam, Netherlands.
37Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA.
38Amgen Inc, Ctr Observat Res, Thousand Oaks, CA 91320 USA.
39Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, NL-9700 RB Groningen, Netherlands.
40Univ Laval, Dept Kinesiol, Quebec City, PQ G1V 0A6, Canada.
41Univ Laval, Inst Nutr & Funct Foods, Quebec City, PQ G1V 0A6, Canada.
42Imperial Coll London, Sch Publ Hlth, Dept Genom Common Dis, London W12 0NN, England.
43Univ Oxford, Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Oxford OX3 7LJ, England.
44Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.
45Harvard Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
46Univ Milan, San Paolo Hosp, Dept Hlth Sci, I-20139 Milan, Italy.
47Filarete Fdn, Genom & Bioinformat Unit, I-20139 Milan, Italy.
48Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
49Univ Eastern Finland, Dept Med, Kuopio 70210, Finland.
50Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA.
51Univ Med Greifswald, Inst Community Med, D-17475 Greifswald, Germany.
52Univ Med Greifswald, Interfac Inst Genet & Funct Genom, D-17475 Greifswald, Germany.
53Amgen Inc, deCODE Genet, IS-101 Reykjavik, Iceland.
54Netherlands Heart Inst, Interuniv Cardiol Inst Netherlands, Durrer Ctr Cardiogenet Res, NL-3501 DG Utrecht, Netherlands.
55Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9700 RB Groningen, Netherlands.
56Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-9700 RB Groningen, Netherlands.
57Icahn Sch Med Mt Sinai, Dept Prevent Med, New York, NY 10029 USA.
58MIT, Program Med & Populat Genet, Cambridge, MA 02142 USA.
59Boston Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA.
60Boston Childrens Hosp, Div Genet & Endocrinol, Boston, MA 02115 USA.
61Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Teviot Pl, Edinburgh EH8 9AG, Midlothian, Scotland.
62Erasmus MC, Dept Epidemiol, Genet Epidemiol Unit, NL-3015 GE Rotterdam, Netherlands.
63UCL, MRC Unit Lifelong Hlth & Ageing, London WC1B 5JU, England.
64Imperial Coll London, Dept Epidemiol & Biostat, London W2 1PG, England.
65Ealing Hosp NHS Trust, London UB1 3HW, Middx, England.
66Imperial Coll London, Sch Publ Hlth, Ctr Environm & Hlth, MRC Hlth Protect Agcy,Dept Epidemiol & Biostat, London W12 0NN, England.
67Univ Groningen, Univ Med Ctr Groningen, Dept Med, NL-9700 RB Groningen, Netherlands.
68Univ Washington, Dept Med, Seattle, WA 98101 USA.
69Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA.
70Pathwest Lab Med Western Australia, Nedlands, WA 6009, Australia.
71Univ Western Australia, Sch Pathol & Lab Med, Nedlands, WA 6009, Australia.
72Queensland Univ Technol, Inst Hlth & Biomed Innovat, Genom Res Ctr, Brisbane, Qld 4001, Australia.
73Agcy Sci Technol & Res Singapore, Genome Inst Singapore, Human Genet, Singapore 138672, Singapore.
74Cedars Sinai Med Ctr, Diabet & Obes Res Inst, Los Angeles, CA 90048 USA.
75Univ Texas Rio Grande Valley, South Texas Diabet & Obes Inst, Brownsville, TX 78520 USA.
76Univ Leipzig, IFB Adipos Dis, D-04103 Leipzig, Germany.
77Univ Leipzig, Dept Med, D-04103 Leipzig, Germany.
78NHGRI, Med Genom & Metab Genet Branch, NIH, Bethesda, MD 20892 USA.
79Univ Dresden, Med Fac Carl Gustav Carus, Dept Med 3, D-01307 Dresden, Germany.
80Univ Groningen, Univ Med Ctr Groningen, Life Lines Cohort Study, NL-9700 RB Groningen, Netherlands.
81Harbor UCLA Med Ctr, Los Angeles BioMed Resesarch Inst, Torrance, CA 90502 USA.
82Univ Sassari, I-07100 Sassari, Italy.
83Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, NL-1081 BT Amsterdam, Netherlands.
84Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens 17671, Greece.
85Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 1, D-85764 Neuherberg, Germany.
86Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 2, D-85764 Neuherberg, Germany.
87Natl Inst Hlth & Welf, Dept Chron Dis Prevent, FI-00271 Helsinki, Finland.
88Univ Helsinki, Dept Gen Practice & Primary Hlth Care, FI-00014 Helsinki, Finland.
89Univ Med Greifswald, Inst Clin Chem & Lab Med, D-17475 Greifswald, Germany.
90AOU Univ Sassari, Hypertens & Related Dis Ctr, I-7100 Sassari, Italy.
91German Ctr Diabet Res DZD, D-85764 Neuherberg, Germany.
92Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, D-85764 Neuherberg, Germany.
93Tech Univ, Dept Med 3, Pathobiochem, D-01307 Dresden, Germany.
94Karolinska Inst, Dept Med, Stockholm, Sweden.
95Karolinska Inst, Atherosclerosis Res Unit, Dept Med Solna, S-17176 Stockholm, Sweden.
96Karolinska Univ Hosp, Ctr Mol Med, S-17176 Stockholm, Sweden.
97Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, NL-9700 RB Groningen, Netherlands.
98Kuopio Res Inst Exercise Med, Kuopio 70100, Finland.
99Univ Exeter, Inst Biomed & Clin Sci, Barrack Rd, Exeter EX2 5DW, Devon, England.
100Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, N-7489 Trondheim, Norway.
101Univ Western Australia, Sch Populat Hlth, Nedlands, WA 6009, Australia.
102Glostrup Cty Hosp, Res Ctr Prevent & Hlth, DK-2600 Glostrup, Denmark.
103Sir Charles Gairdner Hosp, Dept Pulm Physiol & Sleep Med, Nedlands, WA 6009, Australia.
104Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, DK-2200 Copenhagen, Denmark.
105Aalborg Univ, Fac Med, DK-9220 Aalborg, Denmark.
106Capital Region Denmark, Res Ctr Prevent & Hlth, DK-2600 Glostrup, Denmark.
107Tampere Univ Hosp, Dept Clin Physiol, FI-33521 Tampere, Finland.
108Univ Tampere, Sch Med, Dept Clin Physiol, FI-33014 Tampere, Finland.
109Echinos Med Ctr, Echinos 67300, Greece.
110Addenbrookes Hosp, Clin Gerontol Unit, Box 251,Hills Rd, Cambridge CB2 2QQ, England.
111Univ Oulu, Fac Med, Inst Hlth Sci, FI-90014 Oulu, Finland.
112Oulu Univ Hosp, Unit Gen Practice, FI-90029 Oulu, Finland.
113Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland.
114Univ Helsinki, Abdominal Ctr Endocrinol, Dept Med, Helsinki 00290, Finland.
115Minerva Fdn, Helsinki 00290, Finland.
116Univ Split, Fac Med, Dept Publ Hlth, Split 21000, Croatia.
117Kuopio Univ Hosp, Kuopio 70029, Finland.
118Univ Eastern Finland, Dept Clin Physiol & Nucl Med, FI-70211 Kuopio, Finland.
119UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.
120German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Human Genet, D-85764 Neuherberg, Germany.
121Univ Oxford, Big Data Inst, Oxford OX3 7LJ, England.
122Rigshosp, Dept Clin Expt Res, DK-2600 Glostrup, Denmark.
123Strangeways Res Lab Worts Causeway, Cambridge CB1 8RN, England.
124Lund Univ, Diabet Ctr, S-22100 Malmo, Sweden.
125Lund Univ, Dept Clin Sci, Diabet & Endocrinol Unit, S-22100 Malmo, Sweden.
126Univ Vita Salute San Raffaele, Chair Nephrol, I-20139 Milan, Italy.
127IRCCS San Raffaele Sci Inst, Genom Renal Dis & Hypertens Unit, I-20139 Milan, Italy.
128Univ Bristol, Sch Social & Community Med, Bristol BS82BN, Avon, England.
129Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Program Biostat & Biomath, Seattle, WA 98109 USA.
130Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA.
131Univ Maryland, Sch Med, Div Endocrinol Diabet & Nutr, Program Personalized & Genom Med, Baltimore, MD 21201 USA.
132Univ Liverpool, Dept Biostat, Liverpool L69 3GA, Merseyside, England.
133Univ Dresden, Med Fac Carl Gustav Carus, Ctr Evidence Based Healthcare, D-01307 Dresden, Germany.
134Sir Charles Gairdner Hosp, Dept Resp Med, Nedlands, WA 6009, Australia.
135Univ Cambridge, Dept Paediat, Cambridge CB2 0QQ, England.
136Univ Southampton, Southampton Gen Hosp, MRC Lifecourse Epidemiol Unit, Southampton SO16 6YD, Hants, England.
137Massachusetts Gen Hosp, Ctr Human Genet Res, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA.
138Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN 55455 USA.
139Univ Bristol, Sch Social & Community Med, MRC Integrat Epidemiol Unit, Bristol BS8 1TH, Avon, England.
140Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, AJ Ernstr 1887, NL-1081 HL Amsterdam, Netherlands.
141Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, AJ Ernstr 1887, NL-1081 HL Amsterdam, Netherlands.
142European Acad Bozen Bolzano EURAC, Ctr Biomed, I-39100 Bolzano, Italy.
143Inst Univ Lubeck, D-23562 Lubeck, Germany.
144CNR, Ist Ric Genet & Biomed, I-9042 Monserrato, Italy.
145Univ Lubeck, Dept Neurol, D-23562 Lubeck, Germany.
146Gen Cent Hosp, Dept Neurol, I-39100 Bolzano, Italy.
147Turku Univ Hosp, Dept Clin Physiol & Nucl Med, FI-20521 Turku, Finland.
148Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, FI-20520 Turku, Finland.
149Pennington Biomed Res Ctr, Human Genom Lab, Baton Rouge, LA 70808 USA.
150Wellcome Trust Sanger Inst, Human Genet, Hinxton CB10 1HH, England.
151Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA.
152Harvard Med Sch, Boston, MA 02115 USA.
153Univ Oulu, Bioctr Oulu, FI-90014 Oulu, Finland.
154Univ Oulu, Ctr Life Course Hlth Res, FI-90014 Oulu, Finland.
155Ludwig Maximilians Univ Munchen, Inst Med Informat Biometry & Epidemiol, Chair Genet Epidemiol, D-81377 Munich, Germany.
156Anogia Med Ctr, Anogia 74051, Greece.
157Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, NL-9700 RB Groningen, Netherlands.
158UCL, Inst Ophthalmol, London EC1V 9EL, England.
159Univ Turku, Dept Med, FI 20521 Turku, FI-20521 Turku, Finland.
160Turku Univ Hosp, Div Med, Turku, Finland.
161Univ Laval, Sch Nutr, Quebec City, PQ G1V 0A6, Canada.
162Univ Hosp Lausanne CHUV, Dept Internal Med, CH-1011 Lausanne, Switzerland.
163Univ Lausanne, CH-1011 Lausanne, Switzerland.
164Univ Tromso, Fac Hlth Sci, Dept Community Med, N-9037 Tromso, Norway.
165Imperial Coll Healthcare NHS Trust, London W12 0HS, England.
166Univ Southern Denmark, Fac Hlth Sci, DK-5000 Odense, Denmark.
167Imperial Coll London, Sch Publ Hlth, MRC PHE Ctr Environm & Hlth, Dept Epidemiol & Biostat, London W12 0NN, England.
168Univ Oulu, Ctr Life Course Epidemiol, Fac Med, POB 5000, FI-90014 Oulu, Finland.
169Helsinki Univ Hosp, Childrens Hosp, FI-00029 Helsinki, Finland.
170Univ Helsinki, FI-00029 Helsinki, Finland.
171Oulu Univ Hosp, MRC Oulu, Dept Obstet & Gynecol, FI-90029 Oulu, Finland.
172Univ Oulu, FI-90029 Oulu, Finland.
173Imperial Coll London, Natl Heart & Lung Inst, London W12 0NN, England.
174Univ Eastern Finland, Inst Biomed, Dept Physiol, Kuopio Campus, Kuopio 70210, Finland.
175Univ Tampere, Sch Med, Dept Clin Chem, FI-33014 Tampere, Finland.
176Univ Tampere, Fimlab Labs, Dept Clin Chem, FI-33520 Tampere, Finland.
177Univ Tampere, Sch Med, FI-33520 Tampere, Finland.
178Univ Tromso, Fac Hlth Sci, Dept Clin Med, N-9037 Tromso, Norway.
179Univ Adelaide, Sch Publ Hlth, Adelaide, SA 5005, Australia.
180Univ Adelaide, Robinson Res Inst, Adelaide, SA 5005, Australia.
181DZHK German Ctr Cardiovasc Res, Partnersite Munich Heart Alliance, D-80802 Munich, Germany.
182Univ Washington, Dept Epidemiol, Washington, DC 98101 USA.
183Univ Washington, Dept Hlth Serv, Washington, DC 98101 USA.
184Grp Hlth Res Inst, Grp Hlth Cooperat, Washington, DC 98101 USA.
185South Ostrobothnia Cent Hosp, FI-60220 Seinajoki, Finland.
186Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, Kuopio 70211, Finland.
187German Ctr Diabet Res DZD, Paul Langerhans Inst Dresden, D-01307 Dresden, Germany.
188Vet Adm Med Ctr, Geriatr Res & Educ Clin Ctr, Baltimore, MD 21042 USA.
189Univ Bristol, Sch Social & Community Med, MRC Integrat Epidemiol Unit, Bristol BS8 2BN, Avon, England.
190Bispebjerg & Frederiksberg Hosp, Inst Prevent Med, DK-2000 Frederiksberg, Denmark.
191Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland.
192Natl Inst Hlth & Welf, Diabet Prevent Unit, FI-00271 Helsinki, Finland.
193Danube Univ Krems, Ctr Vasc Prevent, A-3500 Krems, Austria.
194King Abdulaziz Univ, Diabet Res Grp, Jeddah 21589, Saudi Arabia.
195Univ Eastern Finland, Dept Publ Hlth & Clin Nutr, Kuopio 70211, Finland.
196Kuopio Univ Hosp, Res Unit, Kuopio 70029, Finland.
197DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, D-17475 Greifswald, Germany.
198King Abdulaziz Univ, PACER HD, Jeddah 21589, Saudi Arabia.
199Ctr Med Syst Biol, NL-2300 Leiden, Netherlands.
200Univ Helsinki, Finnish Inst Mol Med FIMM, Helsinki 00014, Finland.
201Helmholtz Zentrum Munchen, Inst Genet Epidemiol, D-85764 Neuherberg, Germany.
202Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
203Albert Einstein Coll Med, Dept Epidemiol & Popualt Hlth, Bronx, NY 10461 USA.
204Oxford NIHR Biomed Res Ctr, Oxford OX3 7LJ, England.
205Univ North Carolina Chapel Hill, Dept Epidemiol, Carolina Ctr Genome Sci, Chapel Hill, NC 27599 USA.
206NIA, NIH, Bethesda, MD 20892 USA.
207St Georges Univ London, Populat Hlth Res Inst, London SW17 0RE, England.
208Univ Exeter, Sch Med, Genet Complex Traits, Exeter EX1 2LU, Devon, England.
209Broad Inst, Metab Initiat, Cambridge, MA 02142 USA.
210Ludwig Maximilians Univ Munchen, Univ Hosp Grosshadern, Dept Med 1, D-81377 Munich, Germany.
211Icahn Sch Med Mt Sinai, Genet Obes & Related Metab Traits Program, New York, NY 10029 USA.
212Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA.
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.8 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2019051015060
Language: English
Published: Springer Nature, 2016
Publish Date: 2019-05-10
Description:

Abstract

Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways.

see all

Series: Nature communications
ISSN: 2041-1723
ISSN-E: 2041-1723
ISSN-L: 2041-1723
Volume: 7
Article number: 13357
DOI: 10.1038/ncomms13357
OADOI: https://oadoi.org/10.1038/ncomms13357
Type of Publication: A1 Journal article – refereed
Field of Science: 3142 Public health care science, environmental and occupational health
Subjects:
EU Grant Number: (633595) DYNAHEALTH - Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging
Copyright information: © The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
  https://creativecommons.org/licenses/by/4.0/