University of Oulu

Pyrhönen, K., Kulmala, P., Näyhä, S., & Läärä, E. (2019). Diverse age-incidence patterns of atopic sensitization in an unselected Finnish population up to 12 years. Annals of Allergy, Asthma & Immunology, 122(5), 522–531.e3. https://doi.org/10.1016/j.anai.2019.02.027

Diverse age-incidence patterns of atopic sensitization in an unselected Finnish population up to 12 years

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Author: Pyrhönen, Kaisa1; Kulmala, Petri2,3; Näyhä, Simo4;
Organizations: 1Center for Life Course Health Research, University of Oulu, Oulu, Finland
2PEDEGO Research Unit and MRC Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland
3Biomedicine Research Unit, Medical Microbiology and Immunology, University of Oulu, Oulu, Finland
4Faculty of Medicine, University of Oulu, Oulu, Finland
5Research Unit for Mathematical Sciences, University of Oulu, Oulu, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2019051515578
Language: English
Published: Elsevier, 2019
Publish Date: 2020-03-08
Description:

Abstract

Background: The temporal sequence in which allergic sensitization to different allergens emerges is not well characterized at the level of general population.

Objective: We describe the incidence patterns of atopic sensitization to different allergens from birth up to 12 years of age in an unselected Finnish population.

Methods: The study population comprised all children born between 2001 and 2006 identified from the nationwide population register as residents of the province of South Karelia, Finland (n = 5564). The results of allergy tests (22,380 results from skin prick tests, immunoglobulin E [IgE] antibodies, and open food challenges [OFCs], performed in 1827 children) were collected from patient records of all the health care units in the area.

Results: The incidence rates of positive results for food and animal allergens as well as positive OFCs for cow’s milk showed prominent peaks at 5 months of age. Positive results for pollen allergens started to emerge after 1.5 years of age. The 12-year cumulative incidence of sensitization to food, animal, pollen, and any allergens was 12%, 8%, 10%, and 18%, respectively. The cumulative incidence of sensitization to house dust mites was 1% and to molds or latex less than 1%. Firstborn boys had the highest, and those who were not firstborn girls and children born in rural municipalities had the lowest early incidence of sensitization to inhalation allergens.

Conclusion: In the unselected population, the atopic sensitization against food and animal allergens began before 6 months of age and was followed by sensitization to pollen allergens before 2 years of age. Primary prevention of sensitization to food and inhalation allergens should therefore occur in early infancy.

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Series: Annals of allergy, asthma, & immunology
ISSN: 1081-1206
ISSN-E: 1534-4436
ISSN-L: 1081-1206
Volume: 122
Issue: 5
Pages: 522 - 531.e3
DOI: 10.1016/j.anai.2019.02.027
OADOI: https://oadoi.org/10.1016/j.anai.2019.02.027
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
3121 General medicine, internal medicine and other clinical medicine
Subjects:
Funding: The data collection and the work of the principal investigator (the first author) in years 2005 to 2006 was mainly funded by the Social Insurance Institution of Finland and partly by EVO grants from the hospital districts of South Karelia and Northern Ostrobothnia, by Lappeenranta City Council and personal grants from the Finnish Cultural Foundation, South Karelia Regional fund, Finland; the Viipuri Tuberculosis Foundation, Finland; the Väinö and Laina Kivi Foundation, Finland; the Tyyni Tani Foundation, Finland; Kymenlaakson Terveyden Turva ry, Finland; the Allergy Foundation, Finland; and the Medical Society of South Karelia, Finland. The work of the principal investigator was funded in years 2012 to 2014 by University of Oulu and Lappeenranta University of Technology. In 2016 to 2019, the extended data collection and the work of the principal investigator was funded by the Finnish Cultural Foundation (Pekka and Jukka-Pekka Lylykari's Fund), Finland; South Karelia Regional Fund (Lauri and Lahja Hotinen Fund), Finland and by the Viipuri Tuberculosis Foundation, Finland, and the Finnish Pediatric Research Foundation, Finland. The work of the second author was supported by the research grants from the Alma and K.A. Snellman Foundation, Finland; the Finnish Medical Association, Finland; the Allergy Research Foundation, Finland and the Finnish Pediatric Research Foundation, Finland. None of the funding organizations was involved in the design or execution of the study.
Copyright information: © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http:/creativecommons.org/licenses/by-nc-nd/4.0/
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