University of Oulu

H. Ikonen, S. Palaniswamy, T. Nordström, M.R. Järvelin, K.H. Herzig, E. Jääskeläinen, J. Seppälä, J. Miettunen, S. Sebert, Vitamin D status and correlates of low vitamin D in schizophrenia, other psychoses and non-psychotic depression – The Northern Finland Birth Cohort 1966 study, Psychiatry Research, Volume 279, 2019, Pages 186-194, ISSN 0165-1781, https://doi.org/10.1016/j.psychres.2019.02.060

Vitamin D status and correlates of low vitamin D in schizophrenia, other psychoses and non-psychotic depression : the Northern Finland Birth Cohort 1966 study

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Author: Ikonen, H.1; Palaniswamy, S.1,2,3; Nordström, T.1,4,5;
Organizations: 1Centre for Life Course Health Research, University of Oulu, Oulu, Finland
2Biocenter Oulu, University of Oulu, Oulu, Finland
3Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom
4Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
5Northern Finland Birth Cohorts, Faculty of Medicine, University of Oulu, Oulu, Finland
6Unit of Primary Care, Oulu University Hospital, Oulu, Finland
7Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Kingston Lane, Uxbridge, Middlesex UB8 3PH, United Kingdom
8Institute of Biomedicine, Department of Physiology, University of Oulu, Oulu, Finland
9Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland
10Department of Mental and Substance Use Services, Eksote, Lappeenranta, Finland
11Department of Genomics of Complex Diseases, School of Public Health, Imperial College London, London, United Kingdom
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2019052016110
Language: English
Published: Elsevier, 2019
Publish Date: 2020-03-12
Description:

Abstract

There is limited knowledge available on the association of vitamin D with psychiatric disorders in young adults. We aimed to investigate vitamin D levels and associating factors in schizophrenia, other psychoses and non-psychotic depression. We studied 4,987 participants from the Northern Finland Birth Cohort 1966 (31 years) with available serum 25-hydroxyvitamin D [25(OH)D] measurements. The final sample was divided into four groups: schizophrenia (n = 40), other psychoses (n = 24), non-psychotic depression (n = 264) and control (n = 4659). To account for the influence of environmental and technical covariates, we generated a vitamin D score variable with correction for season, sex, batch effect and latitude. We further examined how vitamin D levels correlate with anthropometric, lifestyle, socioeconomic and psychiatric measures. Neither serum 25(OH)D concentration nor vitamin D score differed between schizophrenia, other psychoses, non-psychotic depression and control group. The prevalence of vitamin D deficiency was 3.2%, insufficiency 25.5%, and sufficiency 71.3%. Low vitamin D score correlated with regular smoking in the group with schizophrenia. No difference was observed in other psychiatric conditions. We did not find any difference in vitamin D status between schizophrenia, psychoses, non-psychotic depression and control groups, but future studies are warranted to elucidate the role of vitamin D in psychiatric conditions.

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Series: Psychiatry research
ISSN: 0165-1781
ISSN-E: 1872-7123
ISSN-L: 0165-1781
Volume: 279
Pages: 186 - 194
DOI: 10.1016/j.psychres.2019.02.060
OADOI: https://oadoi.org/10.1016/j.psychres.2019.02.060
Type of Publication: A1 Journal article – refereed
Field of Science: 3124 Neurology and psychiatry
Subjects:
Funding: This work was financially supported by the Academy of Finland (MR. J, grant number 24300796, 24302031; JM, 268336); Medical Research Council, UK (grant number G0601653); Biocenter Oulu Doctoral Program, Juho Vainio Foundation, Orion Research Foundation sr., Emil Aaltonen Foundation, and Finnish Cultural Foundation (S.P); European Union's Horizon 2020 research and innovation program for the DynaHEALTH action (grant number 633595), LifeCycle (grant number 733206), and iHealth-T2D (grant number 643774). No funding bodies had any role in study design, data collection and analysis, decision to publish, or the preparation of the manuscript.
EU Grant Number: (633595) DYNAHEALTH - Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging
(733206) LIFECYCLE - Early-life stressors and LifeCycle health
(643774) iHealth-T2D - Family-based intervention to improve healthy lifestyle and prevent Type 2 Diabetes amongst South Asians with central obesity and prediabetes
Academy of Finland Grant Number: 268336
Detailed Information: 268336 (Academy of Finland Funding decision)
Copyright information: © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.
  https://creativecommons.org/licenses/by-nc-nd/4.0/