University of Oulu

Das, N. K., Dey, R., Chakraborty, S., Panigrahi, P. K., Meglinski, I., & Ghosh, N. (2018). Submicron scale tissue multifractal anisotropy in polarized laser light scattering. Laser Physics Letters, 15(3), 35601.

Submicron scale tissue multifractal anisotropy in polarized laser light scattering

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Author: Das, Nandan Kumar1; Dey, Rajib1; Chakraborty, Semanti1;
Organizations: 1Department of Physical Sciences, Indian Institute of Science Education and Research Kolkata Mohanpur-741246, West Bengal, India
2Opto-Electronics and Measurement Techniques, Faculty of Information Technology and Electrical Engineering, University of Oulu, Erkki Koiso-Kanttilankatu 3, Oulu 90570, Finland
3Interdisciplinary Laboratory of Biophotonics, National Research Tomsk State University, Prospect Lenina 36, Tomsk 634050, Russia
4ITMO University, Kronverkskiy Prospect 49, St Petersburg 197101, Russia
5Institute of Biology, Irkutsk State University, 3 Lenin St, Irkutsk 664003, Russia
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 1.3 MB)
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Language: English
Published: IOP Publishing, 2018
Publish Date: 2019-06-03


The spatial fluctuations of the refractive index within biological tissues exhibit multifractal anisotropy, leaving its signature as a spectral linear diattenuation of scattered polarized light. The multifractal anisotropy has been quantitatively assessed by the processing of relevant Mueller matrix elements in the Fourier domain, utilizing the Born approximation and subsequent multifractal analysis. The differential scaling exponent and width of the singularity spectrum appear to be highly sensitive to the structural multifractal anisotropy at the micron/sub-micron length scales. An immediate practical use of these multifractal anisotropy parameters was explored for non-invasive screening of cervical precancerous alterations ex vivo, with the indication of a strong potential for clinical diagnostic purposes.

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Series: Laser physics letters
ISSN: 1612-2011
ISSN-E: 1612-202X
ISSN-L: 1612-2011
Volume: 15
Issue: 3
Article number: 035601
DOI: 10.1088/1612-202X/aa86f2
Type of Publication: A1 Journal article – refereed
Field of Science: 114 Physical sciences
Funding: This work was supported by IISER-Kolkata, an autonomous institute funded by MHRD, Govt. of India. We would also like to acknowledge BRNS-DAE, Govt. of India for funding.
Copyright information: © 2018 Astro Ltd. This is an author-created, un-copyedited version of an article published in Laser Physics Letters. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at