University of Oulu

J. Käkelä, T. Nordström, M. Haapea, E. Jääskeläinen, J. Miettunen, Association between family history of mental disorders and outcome in psychotic disorders, Psychiatry Research, Volume 270, 2018, Pages 616-621, ISSN 0165-1781,

Association between family history of mental disorders and outcome in psychotic disorders

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Author: Käkelä, J.1,2,3; Nordström, T.2,3; Haapea, M.2,3;
Organizations: 1Research Unit of Clinical Neuroscience, Department of Psychiatry, University of Oulu, Oulu, Finland
2Center for Life Course Health Research, University of Oulu, Oulu, Finland
3Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
4Department of Psychiatry, Oulu University Hospital, Oulu, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.8 MB)
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Language: English
Published: Elsevier, 2018
Publish Date: 2019-10-22


We investigated the association of family history of mental disorders, especially psychosis, with occupational and clinical outcome in psychotic disorders in a longitudinal population-based cohort. The Northern Finland Birth Cohort 1986 (n = 9432) was used to gather the data. In total 189 individuals with psychosis were identified by age of 28. The outcome was assessed by using register information regarding occupational activity, disability pension and hospital treatments due to psychiatric cause. Parental psychosis and any psychiatric disorder were used as predictors of outcome. The results showed that presence of any parental psychiatric disorder was associated with higher number of days spent at hospital and higher number of hospitalizations in psychotic disorders, but was not associated with occupational outcome or disability pension. The presence of parental psychosis was not associated with outcome. These findings suggest that the presence of any psychiatric disorder among parents may increase the risk of poorer outcome in psychoses in terms of need of hospitalisations. Based on this study the presence of parental psychosis is not associated with outcome, but the result should be interpreted with caution due to the small sample size and conflict with the results of earlier studies.

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Series: Psychiatry research
ISSN: 0165-1781
ISSN-E: 1872-7123
ISSN-L: 0165-1781
Volume: 270
Pages: 616 - 621
DOI: 10.1016/j.psychres.2018.10.047
Type of Publication: A1 Journal article – refereed
Field of Science: 3124 Neurology and psychiatry
Funding: This study was funded by the Academy of Finland (grant numbers 278,286, 268,336), the Sigrid Jusélius Foundation, the Brain & Behavior Research Foundation, the North Ostrobothnia Regional Fund of the Finnish Cultural Foundation and the University of Oulu Scholarship Foundation. The funders had no role in the design or conduct of the study.
Academy of Finland Grant Number: 278286
Detailed Information: 278286 (Academy of Finland Funding decision)
268336 (Academy of Finland Funding decision)
Copyright information: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license