Non‑curative treatment of patients with oral tongue squamous‑cell carcinoma
|Author:||Mroueh, R.1,2; Haapaniemi, A.1,2; Saarto, T.3,4;|
1Department of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki
2HUS Helsinki University Hospital, P.O. Box 263, 00029 HUS FI-00029, Finland
3Department of Oncology, University of Helsinki
4HUS Helsinki University Hospital, Helsinki, Finland
5Department of Otorhinolaryngology-Head and Neck Surgery, University of Turku
6Turku University Hospital, Turku, Finland
7Cancer and Translational Medicine Unit, University of Oulu, Oulu, Finland
8Medical Research Unit, Oulu University Hospital, Oulu, Finland
9Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland
10Haartman Institute, Helsinki, Finland
11Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland
12Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet
13Karolinska Hospital, Stockholm, Sweden
|Online Access:||PDF Full Text (PDF, 0.6 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2019061220152
|Publish Date:|| 2019-06-12
Purpose: Late-stage OTSCC is associated with poor overall survival (OS). Non-curative treatment approach aims to improve quality of life and prolong survival of patients deemed incurable. The purpose of this study was to investigate the used non-curative treatment modalities for OTSSC and patient survival.
Methods: All patients diagnosed with OTSCC and treated with non-curative intent at the HUS Helsinki University Hospital (Helsinki, Finland) during the 12-year period of 2005–2016 were included. Survival analysis after the non-curative treatment decision was conducted using the Kaplan–Meier method in this population-based study.
Results: Eighty-two patients were identified. A non-curative treatment decision was made at presentation without any previous treatment in 26 patients (7% of all patients diagnosed with OTSCC during the study period). Palliative radiotherapy was administered to 24% of all patients. The average survival time after the non-curative treatment decision was 3.7 months (median 2 and range 0–26).
Conclusions: Due to the short mean survival time after decision for treatment with non-curative intent, and the notable symptom burden in this patient population, a prompt initiation of all non-curative measures is warranted.
European archives of oto-rhino-laryngology
|Pages:||2039 - 2045|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
Open access funding provided by the University of Helsinki and Helsinki University Hospital.
© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licen ses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.