University of Oulu

Oura, P., Auvinen, J., Paananen, M. et al. Osteoporos Int (2019) 30: 985. https://doi.org/10.1007/s00198-019-04843-9

Dairy- and supplement-based calcium intake in adulthood and vertebral dimensions in midlife—the Northern Finland Birth Cohort 1966 Study

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Author: Oura, Petteri1,2,3; Auvinen, Juha1,2; Paananen, Markus1,2;
Organizations: 1Medical Research Center Oulu,Oulu University Hospital and University of Oulu, Oulu, Finland
2Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland
3Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
4Cancer and Translational Medicine Research Unit, Faculty of Medicine, University of Oulu, Oulu, Finland
5Finnish Institute of Occupational Health, Oulu, Finland
6Department of Sports and Exercise Medicine, Oulu Deaconess Institute, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.8 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2019061420594
Language: English
Published: Springer Nature, 2019
Publish Date: 2019-06-14
Description:

Abstract

Summary: Among a representative sample of 1064 Northern Finns, we studied the association of dairy- and supplement-based calcium intake in adulthood with vertebral size in midlife. Inadequate calcium intake (< 800 mg/day) from age 31 to 46 predicted small vertebral size and thus decreased spinal resilience among women but not men.

Introduction: Small vertebral size predisposes individuals to fractures, which are common among aging populations. Although previous studies have associated calcium (Ca) intake with enhanced bone geometry in the appendicular skeleton, few reports have addressed the axial skeleton or the vertebrae in particular. We aimed to investigate the association of dairy- and supplement-based Ca intake in adulthood with vertebral cross-sectional area (CSA) in midlife.

Methods: A sample of 1064 individuals from the Northern Finland Birth Cohort 1966 had undergone lumbar magnetic resonance imaging at the age of 46, and provided self-reported data on diet and Ca intake (dairy consumption and use of Ca supplements) at the ages of 31 and 46. We assessed the association between Ca intake (both continuous and categorized according to local recommended daily intake) and vertebral CSA, using generalized estimating equation and linear regression models with adjustments for body mass index, diet, vitamin D intake, education, leisure-time physical activity, and smoking.

Results: Women with inadequate Ca intake (< 800 mg/day) over the follow-up had 3.8% smaller midlife vertebral CSA than women with adequate Ca intake (p = 0.009). Ca intake among men showed no association with vertebral CSA.

Conclusions: Inadequate Ca intake (< 800 mg/day) from the age of 31 to 46 predicts small vertebral size and thus decreased spinal resilience among middle-aged women. Future studies should confirm these findings and investigate the factors underlying the association of low Ca intake in women but not in men with smaller vertebral size.

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Series: Osteoporosis international
ISSN: 0937-941X
ISSN-E: 1433-2965
ISSN-L: 0937-941X
Volume: 30
Issue: 5
Pages: 985 - 994
DOI: 10.1007/s00198-019-04843-9
OADOI: https://oadoi.org/10.1007/s00198-019-04843-9
Type of Publication: A1 Journal article – refereed
Field of Science: 3142 Public health care science, environmental and occupational health
Subjects:
Funding: NFBC1966 received financial support from the University of Oulu (grant no. 65354, 24000692), the Oulu University Hospital (grant no. 2/97, 8/97, 24301140), the Finnish Ministry of Health and Social Affairs (grant no. 23/251/97, 160/97, 190/97), the National Institute for Health and Welfare, Helsinki, Finland (grant no. 54121), the Regional Institute of Occupational Health, Oulu, Finland (grant no. 50621, 54231), and the European Regional Development Fund (grant no. 539/2010 A31592). P. Oura received financial support from the Finnish Foundation for Nutrition Research (Ravitsemuksen tutkimussäätiö), the Vappu Uuspää Foundation (Vappu Uuspään säätiö), and the Päivikki and Sakari Sohlberg Foundation (Päivikki ja Sakari Sohlbergin säätiö). Open access funding provided by University of Oulu including Oulu University Hospital.
Dataset Reference: Supplementary material
  https://static-content.springer.com/esm/art%3A10.1007%2Fs00198-019-04843-9/MediaObjects/198_2019_4843_MOESM1_ESM.docx
Copyright information: © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
  https://creativecommons.org/licenses/by-nc/4.0/