University of Oulu

Hirvasniemi, J., Thevenot, J., Guermazi, A. et al. Eur Radiol (2017) 27: 4874.

Differences in tibial subchondral bone structure evaluated using plain radiographs between knees with and without cartilage damage or bone marrow lesions : the Oulu knee osteoarthritis study

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Author: Hirvasniemi, Jukka1; Thevenot, Jérôme1,2; Guermazi, Ali3;
Organizations: 1Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, POB 5000, FI-90014 Oulu, Finland
2Infotech Oulu, University of Oulu, Oulu, Finland
3Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA
4Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany
5Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
6Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.6 MB)
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Language: English
Published: Springer Nature, 2017
Publish Date: 2019-06-19


Objectives: To investigate whether subchondral bone structure from plain radiographs is different between subjects with and without articular cartilage damage or bone marrow lesions (BMLs).

Methods: Radiography-based bone structure was assessed from 80 subjects with different stages of knee osteoarthritis using entropy of Laplacian-based image (ELap) and local binary patterns (ELBP), homogeneity index of local angles (HIAngles,mean), and horizontal (FDHor) and vertical fractal dimensions (FDVer). Medial tibial articular cartilage damage and BMLs were scored using the magnetic resonance imaging osteoarthritis knee score. Level of statistical significance was set to p < 0.05.

Results: Subjects with medial tibial cartilage damage had significantly higher FDVer and ELBP as well as lower ELap and HIAngles,mean in the medial tibial subchondral bone region than subjects without damage. FDHor, FDVer, and ELBP were significantly higher, whereas ELap and HIAngles,mean were lower in the medial trabecular bone region. Subjects with medial tibial BMLs had significantly higher FDVer and ELBP as well as lower ELap and HIAngles,mean in medial tibial subchondral bone. FDHor, FDVer, and ELBP were higher, whereas ELap and HIAngles,mean were lower in medial trabecular bone.

Conclusions: Our results support the use of bone structural analysis from radiographs when examining subjects with osteoarthritis or at risk of having it.

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Series: European radiology
ISSN: 0938-7994
ISSN-E: 1432-1084
ISSN-L: 0938-7994
Volume: 27
Issue: 11
Pages: 4874 - 4882
DOI: 10.1007/s00330-017-4826-8
Type of Publication: A1 Journal article – refereed
Field of Science: 3111 Biomedicine
3126 Surgery, anesthesiology, intensive care, radiology
Funding: This study has received funding by the Radiological Society of Finland, the Orion Corporation Research Foundation, Päivikki and Sakari Sohlberg Foundation, Academy of Finland (project 268378), University of Oulu (strategic funding), Sigrid Juselius Foundation, and European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013)/ERC Grant Agreement no. 336267. The funding sources had no role in the study design, data collection or analysis, interpretation of data, writing of the manuscript, or in the decision to submit the manuscript for publication.
EU Grant Number: (336267) 3D-OA-HISTO - Development of 3D Histopathological Grading of Osteoarthritis
Academy of Finland Grant Number: 268378
Detailed Information: 268378 (Academy of Finland Funding decision)
Copyright information: © The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.