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The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) randomized controlled trial : case finding, screening and characteristics of eligible participants |
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| Author: | Marzetti, Emanuele1; Cesari, Matteo2,3; Calvani, Riccardo1; |
| Organizations: |
1Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy 2Department of Clinical Sciences and Community Health, University of Milan, Italy 3Geriatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
4Sanofi R&D, Chilly-Mazarin, Paris, France
5Service of Geriatrics, Getafe University Hospital, Madrid, Spain 6Scientific Direction, IRCCS INRCA, Ancona, Italy 7Geriatria, Accettazione Geriatrica e Centro di Ricerca per l'Invecchiamento, IRCCS INRCA, Ancona, Italy 8Research Unit of Medicine of Aging, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy 9Division of Geriatric Cardiology and Medicine, Department of Geriatrics and Medicine, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy 10Department of Geriatric Rehabilitation, University Hospital of Parma, Parma, Italy 11Department of Medicine and Surgery, University of Parma, Parma, Italy 12Gérontopôle, University Hospital of Toulouse, Toulouse, France 13University Hospital of Limoges, Limoges, France 14Servicio de Geriatría, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain 15Institute for Biomedicine of Aging, Friedrich-Alexander-University, Nuremberg, Germany 16Department of Internal Medicine and Gerontology, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland 17Foundation for Diabetes Research in Older People, Diabetes Frail Limited, Worcestershire, UK 18Department of Geriatrics, First Faculty of Medicine, Charles University, Prague, Czech Republic 19Geriatric Department, Silesians Hospital, Opava, Czech Republic 20University of Helsinki, Clinicum, Helsinki, Finland 21Helsinki University Hospital, Medicine and Rehabilitation, Helsinki, Finland 22University of Oulu, Center for Life Course Health Research, Oulu, Finland 23Department of Respiratory Medicine, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center, Maastricht, the Netherlands 24Department of Health Services Research, Maastricht University Medical Center, Maastricht, the Netherlands 25Department of Internal Medicine, Medical University of Graz, Graz, Austria 26Department of Geriatrics, Faculty of Medicine, Landspitali University Hospital, University of Iceland, Reykjavik, Iceland 27BlueCompanion Ltd., London, UK 28Biophytis, Paris, France 29Department of Aging and Geriatric Research, Institute on Aging, University of Florida, Gainesville, FL, USA 30Translational Medicine, Novartis Institutes for Biomedical Research, Basel, Switzerland |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 1.5 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2019062021529 |
| Language: | English |
| Published: |
Elsevier,
2018
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| Publish Date: | 2019-06-20 |
| Description: |
AbstractBackground: The ongoing “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies (SPRINTT)” randomized controlled trial (RCT) is testing the efficacy of a multicomponent intervention in the prevention of mobility disability in older adults with physical frailty & sarcopenia (PF&S). Here, we describe the procedures followed for PF&S case finding and screening of candidate participants for the SPRINTT RCT. We also illustrate the main demographic and clinical characteristics of eligible screenees. Methods: The identification of PF&S was based on the co-occurrence of three defining elements: (1) reduced physical performance (defined as a score on the Short Physical Performance Battery between 3 and 9); (2) low muscle mass according to the criteria released by the Foundation for the National Institutes of Health; and (3) absence of mobility disability (defined as ability to complete the 400-m walk test in 15 min). SPRINTT was advertised through a variety of means. Site-specific case finding strategies were developed to accommodate the variability across centers in catchment area characteristics and access to the target population. A quick “participant profiling” questionnaire was devised to facilitate PF&S case finding. Results: During approximately 22 months, 12,358 prescreening interviews were completed in 17 SPRINTT sites resulting in 6710 clinic screening visits. Eventually, 1566 candidates were found to be eligible for participating in the SPRINTT RCT. Eligible screenees showed substantial physical function impairment and comorbidity burden. In most centers, project advertisement through mass media was the most rewarding case finding strategy. Conclusion: PF&S case finding in the community is a challenging, but feasible task. Although largely autonomous in daily life activities, older adults with PF&S suffer from significant functional impairment and comorbidity. This subset of the older population is therefore at high risk for disability and other negative health-related events. Key strategies to consider for successfully intercepting at-risk older adults should focus on mass communication methods. see all
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| Series: |
Experimental gerontology |
| ISSN: | 0531-5565 |
| ISSN-E: | 0531-5565 |
| ISSN-L: | 0531-5565 |
| Volume: | 113 |
| Pages: | 48 - 57 |
| DOI: | 10.1016/j.exger.2018.09.017 |
| OADOI: | https://oadoi.org/10.1016/j.exger.2018.09.017 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3121 General medicine, internal medicine and other clinical medicine |
| Subjects: | |
| Funding: |
The present work was funded by a grant from the Innovative Medicines Initiative - Joint Undertaking (IMI-JU 115621). The work was also partly supported by the nonprofit research foundation “Centro Studi Achille e Linda Lorenzon” and by intramural research grants from the Università Cattolica del Sacro Cuore (D3.2 2013 and D3.2 2015). |
| Copyright information: |
© 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/ |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |