University of Oulu

Rintala, M., Vahlberg, T., Salo, T., Rautava, J. (2018) Proliferative verrucous leukoplakia and its tumor markers: Systematic review and meta‐analysis. 41 (5), 1499-1507. doi:10.1002/hed.25569

Proliferative verrucous leukoplakia and its tumor markers : systematic review and meta‐analysis

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Author: Rintala, Mirjami1; Vahlberg, Tero2; Salo, Tuula3,4,5,6;
Organizations: 1Faculty of Medicine, Department of Oral Pathology, Institute of Dentistry, University of Turku, Turku, Finland
2Biostatistics, Department of Clinical Medicine, University of Turku and Turku University Hospital, Turku, Finland
3Helsinki University Central Hospital, Helsinki, Finland
4Department of Oral Pathology, Institute of Dentistry, University of Helsinki, Helsinki, Finland
5Finland Cancer and Translational Medicine Research Unit, University of Oulu, Oulu, Finland
6Medical Research Center Oulu, Oulu, Finland
7Department of Pathology, Turku University Hospital, Turku, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2019062021544
Language: English
Published: John Wiley & Sons, 2018
Publish Date: 2020-04-16
Description:

Abstract

Background: The aim was to update information on oral proliferative verrucous leukoplakia (PVL), a disease of verrucous‐like lesions with high risk of malignancy, and its biomarkers.

Methods: A systematic search of literature on PVL and its biomarkers showed 22 biomarkers that were investigated in 19 papers. A meta‐analysis was possible for human papillomavirus (HPV), aneuploidy, Ki‐67, and p53.

Results: Aneuploidy was found consistently (I2 = 0%, P = 0.61) in 92% (95% CI 80%‐99%) of the PVL cases. P53 positivity prevalence was 27% (95% CI 15%‐40%) in two available studies (I2 = 0%, P = 0.64). With HPV and Ki‐67, the most outlying studies needed to be removed and after that the pooled HPV positivity prevalence (I2 = 24%, P = 0.27) was 5% (95% CI 0%‐14%) and for Ki‐67 (I2 = 9%, P = 0.33) 14% (95% CI 6%‐26%).

Conclusions: With the evidence of the current literature, aneuploidy could value as a biomarker of PVL but should be further validated.

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Series: Head & neck
ISSN: 1043-3074
ISSN-E: 1097-0347
ISSN-L: 1043-3074
Volume: 41
Pages: 1499 - 1507
DOI: 10.1002/hed.25569
OADOI: https://oadoi.org/10.1002/hed.25569
Type of Publication: A2 Review article in a scientific journal
Field of Science: 3122 Cancers
Subjects:
Copyright information: © 2018 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Rintala, M., Vahlberg, T., Salo, T., Rautava, J. (2018) Proliferative verrucous leukoplakia and its tumor markers: Systematic review and meta‐analysis. 41 (5), 1499-1507. doi:10.1002/hed.25569, which has been published in final form at https://doi.org/10.1002/hed.25569. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.