Anne-Mari J. Mustonen, Mikko A. J. Finnilä, Katri S. Puukka, Timo J. Jämsä, Simo Saarakkala, Juha K. Tuukkanen, T. Petteri Nieminen, Raccoon dog model shows preservation of bone during prolonged catabolism and reduced physical activity, Journal of Experimental Biology 2017 220: 2196-2202; doi: 10.1242/jeb.135475
Raccoon dog model shows preservation of bone during prolonged catabolism and reduced physical activity
|Author:||Mustonen, Anne-Mari J.1,2; Finnilä, Mikko A. J.3,4,5; Puukka, Katri S.6,7;|
1University of Eastern Finland, Faculty of Health Sciences, School of Medicine, Institute of Biomedicine/Anatomy, PO Box 1627, Kuopio FI-70211, Finland
2University of Eastern Finland, Faculty of Science and Forestry, Department of Environmental and Biological Sciences, PO Box 111, Joensuu FI-80101, Finland
3University of Oulu, Faculty of Medicine, Research Unit of Medical Imaging, Physics and Technology, PO Box 5000, Oulu FI-90014, Finland
4University of Eastern Finland, Faculty of Science and Forestry, Department of Applied Physics, PO Box 1627, Kuopio FI-70211, Finland
5Medical Research Center Oulu, Oulu University Hospital and University of Oulu, PO Box 5000, Oulu FI-90014, Finland
6NordLab Oulu, Oulu University Hospital, PO Box 500, Oulu FI-90029, OYS, Finland
7University of Oulu, Faculty of Medicine, Department of Clinical Chemistry, PO Box 8000, Oulu FI-90014, Finland
8Department of Diagnostic Radiology, Oulu University Hospital, PO Box 50, Oulu FI-90029, Finland
9University of Oulu, Faculty of Medicine, Research Group of Cancer Research and Translational Medicine, PO Box 5000, Oulu FI-90014, Finland
|Online Access:||PDF Full Text (PDF, 0.4 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2019062622112
Company of Biologists,
|Publish Date:|| 2019-06-26
The raccoon dog (Nyctereutes procyonoides) is a promising animal model capable of preventing disuse-induced osteoporosis. Previous data suggest that this species resembles bears in the preservation of bone mass and biomechanical properties during prolonged passivity and catabolism. This longitudinal study examined the osteological properties of tibiae in farm-bred raccoon dogs that were either fed or fasted (n=6 per group) for a 10 week period. Peripheral quantitative computed tomography was utilized and plasma markers of bone turnover measured before fasting and at 9 weeks followed by mechanical testing (three-point bending), micro-computed tomography and Fourier transform infrared imaging at 10 weeks. Passive wintering with prolonged catabolism (body mass loss 32%) had no significant effects on bone mineralization, porosity or strength. The concentration of C-terminal telopeptide of type I collagen, indicative of bone resorption, increased in the plasma of the fasted raccoon dogs, while the bone formation markers were unchanged. The levels of 25-hydroxyvitamin D were reduced in the fasted animals. Based on these data, the preservation of bone in wintering raccoon dogs shares characteristics with that of bears with no apparent decrease in the formation of bone but increased resorption. To conclude, raccoon dogs were able to minimize bone loss during a 10 week period of catabolism and passivity.
Journal of experimental biology
|Pages:||2196 - 2202|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
The work was supported by the Sigrid Juséliuksen Säätiö [to M.A.J.F.].
© 2017. Published by The Company of Biologists Ltd http://www.biologists.com/user-licence-1-1/.