University of Oulu

Huang, H.-B., Kuo, P.-L., Chang, J.-W., Jaakkola, J. J. K., Liao, K.-W., & Huang, P.-C. (2018). Longitudinal assessment of prenatal phthalate exposure on serum and cord thyroid hormones homeostasis during pregnancy - Tainan birth cohort study (TBCS). Science of The Total Environment, 619–620, 1058–1065.

Longitudinal assessment of prenatal phthalate exposure on serum and cord thyroid hormones homeostasis during pregnancy : Tainan birth cohort study (TBCS)

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Author: Huang, Han-Bin1; Kuo, Pao-Lin2; Chang, Jung-Wei3;
Organizations: 1School of Public Health, National Defense Medical Center, Taipei, Taiwan
2Department of Obstetric and Gynecology, National Cheng Kung University Hospital, College of Medicine, Tainan, Taiwan
3Research Center for Environmental Trace Toxic Substances, National Cheng Kung University, Tainan, Taiwan
4Center for Environmental and Respiratory Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland
5Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland
6National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan
7Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.8 MB)
Persistent link:
Language: English
Published: Elsevier, 2018
Publish Date: 2019-11-29


An increasing number of studies have revealed that phthalate exposure alters thyroid hormone homeostasis in the general population, but there is insufficient evidence of the effect of longitudinal maternal phthalate exposure on maternal and fetal thyroid hormones during pregnancy. We longitudinally assessed the effect of prenatal phthalate exposure in pregnant women on umbilical cord and maternal thyroid hormones at three trimesters during pregnancy. We recruited 98 pregnant women and collected urine and blood samples at three trimesters in an obstetrics clinic in Southern Taiwan from 2013 to 2014. We analyzed the concentrations of 11 urinary phthalate metabolites, including monoethylhexyl phthalate, mono-(2-ethyl-5-oxo-hexyl) phthalate (MEOHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate, mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono-n-butyl phthalate, monoisobutyl phthalate (MiBP), monoethyl phthalate (MEP), using online liquid chromatography–tandem mass spectrometry. The cord and maternal serum levels of thyroxine (T₄), free T₄, triiodothyronine (T₃), thyroid-stimulating hormone (TSH), and thyroxine-binding globulin were measured using an electrochemiluminescence immunoassay. A mixed-model analysis was utilized to assess the effect of longitudinal phthalate exposure on thyroid hormones and adjusted for significant covariates. We found that urinary MiBP (β = − 0.065, 95% confidence interval (CI): − 0.124, − 0.005), and MEOHP (β = − 0.083, 95% CI: − 0.157, − 0.009) were significantly negatively associated with serum TSH. Urinary MECPP was inversely related to serum T₃ (β = − 0.027, 95% CI: − 0.047, − 0.006). Urinary MEP (β = 0.014, 95% CI: − 0.001, 0.028) and MiBP (β = 0.033, 95% CI: 0.018, 0.049) were positively related to free T₄. We found that cord serum T₃ (β = 0.067, 95% CI: 0.003, 0.131) and free T₄ (β = 0.031, 95% CI: 0.001, 0.062) levels had significant positive associations with maternal ΣDBPm levels at the second trimester. We concluded that different phthalates exposure windows during gestation may alter cord and serum thyroid hormone homoeostasis.

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Series: Science of the total environment
ISSN: 0048-9697
ISSN-E: 1879-1026
ISSN-L: 0048-9697
Volume: 619-620
Pages: 1058 - 1065
DOI: 10.1016/j.scitotenv.2017.11.048
Type of Publication: A1 Journal article – refereed
Field of Science: 3142 Public health care science, environmental and occupational health
Funding: This study was funded by the National Health Research Institutes (Grant No.: EM-105-PP-15, EM-106-PP-12, EM-107-PP-12 and MOST-105-2314-B-400-032, MOST-106-3314-B-400-001).
Copyright information: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http:/