Ji-Han Xia & Gong-Hong Wei (2018) Oncogenic regulatory circuits driven by 19q13 rs11672691 underlies prostate cancer aggressiveness, Molecular & Cellular Oncology, 5:6, DOI: 10.1080/23723556.2018.1516451
Oncogenic regulatory circuits driven by 19q13 rs11672691 underlies prostate cancer aggressiveness
|Author:||Xi, Ji-Han1; Wei, Gong-Hong1|
1Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, Oulu, Finland
|Online Access:||PDF Full Text (PDF, 2 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2019062822338
|Publish Date:|| 2019-06-28
The 19q13 allele rs11672691 has been reproducibly found in association with aggressive form of prostate cancer, yet the underlying mechanism remains totally unknown. We have recently uncovered a mechanism by which rs11672691 influenced a novel oncogenic regulatory circuit, including HOXA2, PCAT19 and CEACAM21, thereby contributing to prostate cancer aggressiveness.
Molecular & cellular oncology
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
1182 Biochemistry, cell and molecular biology
This work was supported by Academy of Finland (284618 and 279760), Jane and Aatos Erkko Foundation, and Finnish Cancer Foundation.
|Academy of Finland Grant Number:||
284618 (Academy of Finland Funding decision)
279760 (Academy of Finland Funding decision)
© 2018 The Author(s). Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.