University of Oulu

Ji-Han Xia & Gong-Hong Wei (2018) Oncogenic regulatory circuits driven by 19q13 rs11672691 underlies prostate cancer aggressiveness, Molecular & Cellular Oncology, 5:6, DOI: 10.1080/23723556.2018.1516451

Oncogenic regulatory circuits driven by 19q13 rs11672691 underlies prostate cancer aggressiveness

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Author: Xi, Ji-Han1; Wei, Gong-Hong1
Organizations: 1Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 2 MB)
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Language: English
Published: Informa, 2018
Publish Date: 2019-06-28


The 19q13 allele rs11672691 has been reproducibly found in association with aggressive form of prostate cancer, yet the underlying mechanism remains totally unknown. We have recently uncovered a mechanism by which rs11672691 influenced a novel oncogenic regulatory circuit, including HOXA2, PCAT19 and CEACAM21, thereby contributing to prostate cancer aggressiveness.

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Series: Molecular & cellular oncology
ISSN: 2372-3548
ISSN-E: 2372-3556
ISSN-L: 2372-3548
Volume: 5
Issue: 6
Article number: e1516451
DOI: 10.1080/23723556.2018.1516451
Type of Publication: A1 Journal article – refereed
Field of Science: 1182 Biochemistry, cell and molecular biology
3122 Cancers
Funding: This work was supported by Academy of Finland (284618 and 279760), Jane and Aatos Erkko Foundation, and Finnish Cancer Foundation.
Academy of Finland Grant Number: 284618
Detailed Information: 284618 (Academy of Finland Funding decision)
279760 (Academy of Finland Funding decision)
Copyright information: © 2018 The Author(s). Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.