University of Oulu
Oulu University Library
OuluCRIS
Laturi
Muuntaja

Similar Items

Cover Image

Ji-Han Xia & Gong-Hong Wei (2018) Oncogenic regulatory circuits driven by 19q13 rs11672691 underlies prostate cancer aggressiveness, Molecular & Cellular Oncology, 5:6, DOI: 10.1080/23723556.2018.1516451

Oncogenic regulatory circuits driven by 19q13 rs11672691 underlies prostate cancer aggressiveness

Saved in:
Author: Xi, Ji-Han1; Wei, Gong-Hong1
Organizations: 1Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 2 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2019062822338
Language: English
Published: Informa, 2018
Publish Date: 2019-06-28
Description:

Abstract

The 19q13 allele rs11672691 has been reproducibly found in association with aggressive form of prostate cancer, yet the underlying mechanism remains totally unknown. We have recently uncovered a mechanism by which rs11672691 influenced a novel oncogenic regulatory circuit, including HOXA2, PCAT19 and CEACAM21, thereby contributing to prostate cancer aggressiveness.

see all
Series: Molecular & cellular oncology
ISSN: 2372-3548
ISSN-E: 2372-3556
ISSN-L: 2372-3548
Volume: 5
Issue: 6
Article number: e1516451
DOI: 10.1080/23723556.2018.1516451
OADOI: https://oadoi.org/10.1080/23723556.2018.1516451
Type of Publication: A1 Journal article – refereed
Field of Science: 1182 Biochemistry, cell and molecular biology
3122 Cancers
Subjects:
19q13 locus
HOXA2-PCAT19-CEACAM21 regulatory circuit
aggressive prostate cancer
integrated genomic analysis
rs11672691
Article
Funding: This work was supported by Academy of Finland (284618 and 279760), Jane and Aatos Erkko Foundation, and Finnish Cancer Foundation.
Academy of Finland Grant Number: 284618
279760
Detailed Information: 284618 (Academy of Finland Funding decision)
279760 (Academy of Finland Funding decision)
Copyright information: © 2018 The Author(s). Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
  https://creativecommons.org/licenses/by-nc-nd/4.0/