University of Oulu

Myhrstad, M. C. W., Mello, V. D., Dahlman, I., Kolehmainen, M., Paananen, J., Rundblad, A., … Ulven, S. M. (2019). Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with Metabolic Syndrome–A SYSDIET Sub‐Study. Molecular Nutrition & Food Research, 1801405. https://doi.org/10.1002/mnfr.201801405

Healthy nordic diet modulates the expression of genes related to mitochondrial function and immune response in peripheral blood mononuclear cells from subjects with metabolic syndrome : a SYSDIET sub-study

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Author: Myhrstad, Mari C. W.1; de Mello, Vanessa D.2; Dahlman, Ingrid3;
Organizations: 1Department of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University, 0130, Oslo, Norway
2Institute of Public Health and Clinical Nutrition, University of Eastern Finland, 70211 Kuopio, Finland
3Department of Medicine (H7), Karolinska Institute, 141 86, Stockholm, Sweden
4Institute of Public Health and Clinical Nutrition, University of Eastern Finland, 70211, Kuopio, Finland
5Department of Nutrition, Institute for Basic Medical Sciences, University of Oslo, 0316, Oslo, Norway
6Institute of Biomedicine, University of Eastern Finland, 70211, Kuopio, Finland
7Department of Medical Biochemistry, Oslo University Hospital, 0424, Oslo, Norway
8Department of Medicine, Endocrinology and Clinical Nutrition, Kuopio University Hospital, 70029 Kuopio, Finland
9Department of Nutrition, Institute for Basic Medical Sciences, University of Oslo, 0316 Oslo, Norway
10Norwegian National Advisory Unit on Familial Hypercholesterolemia, Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, 0424 Oslo, Norway
11Department of Endocrinology and Internal Medicine, Aarhus University Hospital, 8200 Aarhus, Denmark
12Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, DK‐2200 Copenhagen N, Denmark
13Unit for Nutrition Research, University of Iceland and Landspitali – The National University Hospital of Iceland, 101 Reykjavík, Iceland
14Biomedical Nutrition, Pure and Applied Biochemistry, Lund University, 221 00 Lund, Sweden
15Department of Clinical Nutrition, Skåne University Hospital, 221 00 Lund, Sweden
16Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, 751 22 Uppsala, Sweden
17Department of Internal Medicine and Biocenter Oulu, University of Oulu, and Medical Research Center, Oulu University Hospital, 90014 Oulu, Finland
18Institute of Biomedicine and Biocenter of Oulu, University of Oulu, Medical Research Center (MRC) and University Hospital, 90014 Oulu, Finland
19Department of Gastroenterology and Metabolism, Poznań University of Medical Sciences, 10 61‐701 Poznań, Poland
20VTT Technical Research Centre of Finland, 02044 VTT Espoo, Finland
21Department of Medicine (H7), Karolinska Institute, 141 86 Stockholm, Sweden
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2019070122424
Language: English
Published: John Wiley & Sons, 2019
Publish Date: 2020-04-09
Description:

Abstract

Scope: To explore the effect of a healthy Nordic diet on the global transcriptome profile in peripheral blood mononuclear cells (PBMCs) of subjects with metabolic syndrome.

Methods and results: Subjects with metabolic syndrome undergo a 18/24 week randomized intervention study comparing an isocaloric healthy Nordic diet with an average habitual Nordic diet served as control (SYSDIET study). Altogether, 68 participants are included. PBMCs are obtained before and after intervention and total RNA is subjected to global transcriptome analysis. 1302 probe sets are differentially expressed between the diet groups (p‐value < 0.05). Twenty‐five of these are significantly regulated (FDR q‐value < 0.25) and are mainly involved in mitochondrial function, cell growth, and cell adhesion. The list of 1302 regulated probe sets is subjected to functional analyses. Pathways and processes involved in the mitochondrial electron transport chain, immune response, and cell cycle are downregulated in the healthy Nordic diet group. In addition, gene transcripts with common motifs for 42 transcription factors, including NFR1, NFR2, and NF‐κB, are downregulated in the healthy Nordic diet group.

Conclusion: These results suggest that benefits of a healthy diet may be mediated by improved mitochondrial function and reduced inflammation.

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Series: Molecular nutrition & food research
ISSN: 1613-4125
ISSN-E: 1613-4133
ISSN-L: 1613-4125
Volume: 63
Issue: 13
Article number: 1801405
DOI: 10.1002/mnfr.201801405
OADOI: https://oadoi.org/10.1002/mnfr.201801405
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Subjects:
Funding: The project was funded by NordForsk Nordic Centre of Excellence in Food, Nutrition and Health project 070014 (SYSDIET [Systems Biology in Controlled Dietary Interventions and Cohort Studies]) and further, Oslo Metropolitan University-OsloMet (Norway), University of Oslo (Norway), Throne Holst Foundation (Norway), Academy of Finland, Swedish Research Council, Svenska Diabetesförbundet, SRP Diabetes, Finnish Diabetes Research Foundation, Finnish Foundation for Cardiovascular Research, the Sigrid Juselius Foundation, EVO funding from Kuopio University Hospital (Finland), the Druvan Foundation, Skåne University Hospital, the Heart-Lung Foundation, Diabetesfonden and Foundation Cerealia (Sweden), the Danish Obesity Research Centre (DanORC, www.danorc.dk), the Danish Council for Strategic Research (DairyHealth, BioFunCarb) (Denmark), the Agricultural Productivity Fund, and the Research Fund of the University of Iceland (Iceland). M.C.W.M
Copyright information: © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: Myhrstad, M. C. W., Mello, V. D., Dahlman, I., Kolehmainen, M., Paananen, J., Rundblad, A., … Ulven, S. M. (2019). Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with Metabolic Syndrome–A SYSDIET Sub‐Study. Molecular Nutrition & Food Research, 1801405. https://doi.org/10.1002/mnfr.201801405 , which has been published in final form at https://doi.org/10.1002/mnfr.201801405. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.