University of Oulu

Oura, P. , Junno, J. , Auvinen, J. , Niinimäki, J. , Karppinen, J. , Ojaniemi, M. and Paananen, M. (2019), Body Mass Index Trajectories From Birth to Midlife and Vertebral Dimensions in Midlife: the Northern Finland Birth Cohort 1966 Study. JBMR Plus, 3: 37-44. doi:10.1002/jbm4.10065

Body mass index trajectories from birth to midlife and vertebral dimensions in midlife : the Northern Finland birth cohort 1966 study

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Author: Oura, Petteri1,2,3; Junno, Juho‐Antti1,4,5; Auvinen, Juha1,3;
Organizations: 1Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland
2Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
3Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
4Cancer and Translational Medicine Research Unit, Faculty of Medicine, University of Oulu, Oulu, Finland
5Department of Archaeology, Faculty of Humanities, University of Oulu, Oulu, Finland
6Finnish Institute of Occupational Health, Oulu, Finland
7PEDEGO Research Unit, Faculty of Medicine, University of Oulu, Oulu, Finland
8Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.3 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2019070122437
Language: English
Published: John Wiley & Sons, 2019
Publish Date: 2019-07-01
Description:

Abstract

Vertebral fracture risk is higher among individuals with small vertebral dimensions. Obesity is a global health problem and may also contribute to bone size and fracture risk. In this work we report the association between life course body mass index (BMI) and vertebral cross‐sectional area (CSA) in midlife. The Northern Finland Birth Cohort 1966 study with its 46‐year follow‐up provided the material for this study. A subsample of 780 individuals had attended lumbar magnetic resonance imaging (MRI) at the age of 46 years, and had records of objectively measured BMI from the ages of 0, 7, 15, 31, and 46 years. Of these, MRI‐derived data on vertebral size was available for 682 individuals. We identified latent lifelong BMI trajectories by performing latent class growth modeling (LCGM) on the BMI data, and then used sex‐stratified linear regression models to compare the identified trajectory groups in terms of midlife vertebral CSA. Gestational age, education years, adult height, lifelong physical activity, lifelong smoking history, and adulthood diet were assessed as potential confounders. Three distinct trajectory groups (“stable slim,” “stable average,” and “early onset overweight”) were identified among both sexes. Comparisons to the stable slim trajectory revealed that vertebral CSA was significantly (p < 0.001) larger among the stable average and early onset overweight trajectories (69.8 and 118.6 mm² larger among men, 57.7 and 106.1 mm² larger among women, respectively). We conclude that lifelong BMI has a positive association with midlife vertebral size among both sexes. Future studies should characterize the mediating factors of this association.

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Series: JBMR plus
ISSN: 2473-4039
ISSN-E: 2473-4039
ISSN-L: 2473-4039
Volume: 3
Issue: 1
Pages: 37 - 44
DOI: 10.1002/jbm4.10065
OADOI: https://oadoi.org/10.1002/jbm4.10065
Type of Publication: A1 Journal article – refereed
Field of Science: 3142 Public health care science, environmental and occupational health
Subjects:
Funding: This study was funded by University of Oulu (grant numbers 65354 and 24000692), Oulu University Hospital (grant numbers 2/97, 8/97, and 2430114), Ministry of Health and Social Affairs (grant numbers 23/251/97, 160/97, 190/97), National Institute for Health and Welfare (grant number 54121), Regional Institute of Occupational Health, Oulu, Finland (grant numbers 50621 and 54231), and the European Regional Development Fund (grant number 539/2010 A31592).
Copyright information: © 2018 American Society for Bone and Mineral Research. This version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.
  https://creativecommons.org/licenses/by-nc-nd/4.0/