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Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics : the FINGER trial |
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| Author: | Rosenberg, Anna1; Ngandu, Tiia2,3; Rusanen, Minna2,3,4; |
| Organizations: |
1Institute of Clinical Medicine, Department of Neurology, University of Eastern Finland, Kuopio, Finland 2Department of Public Health Solutions, Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland 3Division of Clinical Geriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden
4Department of Neurology, North Karelia Central Hospital, Joensuu, Finland
5Center for Life Course Health Research/Geriatrics, University of Oulu, Oulu, Finland 6Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland 7Oulu City Hospital, Oulu, Finland 8Aging Research Center, Karolinska Institutet-Stockholm University, Stockholm, Sweden 9Aging, Disability and Functioning Unit, National Institute for Health and Welfare, Helsinki, Finland 10Department of Neurology, Kuopio University Hospital, Kuopio, Finland 11Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland 12Joint municipal authority for North Karelia Social and Health services, Joensuu, Finland 13Department of Public Health, University of Helsinki, Helsinki, Finland 14Finnish Institute of Occupational Health, Helsinki, Finland 15Neurocenter, Neurology, Kuopio University Hospital, Kuopio, Finland 16Department of Psychology, Umeå University, Umeå, Sweden 17Department of Social and Psychological Sciences, Karlstad University, Karlstad, Sweden 18University of Helsinki, Helsinki University Hospital, Helsinki, Finland 19South Ostrobothnia Central Hospital, Seinäjoki, Finland 20Stockholms Sjukhem, Research & Development Unit, Stockholm, Sweden |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.4 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2019070122446 |
| Language: | English |
| Published: |
Elsevier,
2018
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| Publish Date: | 2019-07-01 |
| Description: |
AbstractIntroduction: The 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) multidomain lifestyle intervention trial (NCT01041989) demonstrated beneficial effects on cognition. We investigated whether sociodemographics, socioeconomic status, baseline cognition, or cardiovascular factors influenced intervention effects on cognition. Methods: The FINGER recruited 1260 people from the general Finnish population (60–77 years, at risk for dementia). Participants were randomized 1:1 to multidomain intervention (diet, exercise, cognition, and vascular risk management) and regular health advice. Primary outcome was change in cognition (Neuropsychological Test Battery z-score). Prespecified analyses to investigate whether participants’ characteristics modified response to intervention were carried out using mixed-model repeated-measures analyses. Results: Sociodemographics (sex, age, and education), socioeconomic status (income), cognition (Mini–Mental State Examination), cardiovascular factors (body mass index, blood pressure, cholesterol, fasting glucose, and overall cardiovascular risk), and cardiovascular comorbidity did not modify response to intervention (P-values for interaction > .05). Conclusions: The FINGER intervention was beneficial regardless of participants’ characteristics and can thus be implemented in a large elderly population at increased risk for dementia. see all
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| Series: |
Alzheimer's & dementia. The journal of the Alzheimer's Association |
| ISSN: | 1552-5260 |
| ISSN-E: | 1552-5279 |
| ISSN-L: | 1552-5260 |
| Volume: | 14 |
| Issue: | 3 |
| Pages: | 263 - 270 |
| DOI: | 10.1016/j.jalz.2017.09.006 |
| OADOI: | https://oadoi.org/10.1016/j.jalz.2017.09.006 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3124 Neurology and psychiatry |
| Subjects: | |
| Funding: |
This work was supported by the Academy of Finland's Responding to Public Health Challenges Research Programme, project grants 259615, 278457, 287490, 294061, key project funding 305810; Joint Program of Neurodegenerative Disorders–prevention (MIND-AD) grant; La Carita Foundation; Alzheimer Association grant (HAT-10-173121); Juho Vainio Foundation, Finnish Medical Foundation; Novo Nordisk Foundation; Finnish Social Insurance Institution; Ministry of Education and Culture Research grant, and EVO/VTR grants of University Hospitals of Kuopio, Oulu and Turku, Seinäjoki Central Hospital and Oulu City Hospital; Swedish Research Council; Knut and Alice Wallenberg Foundation, Sweden; Center for Innovative Medicine (CIMED) at Karolinska Institutet, Sweden; Stiftelsen Stockholms sjukhem, Sweden; Konung Gustaf V:s och Drottning Victorias Frimurarstiftelse, Sweden; af Jochnick Foundation, Sweden; Alzheimer's Research & Prevention Foundation, USA; AXA Research Fund; University of Eastern Finland Doctoral School. Funding sources had no involvement in study design, collection, analysis or interpretation of data, writing the report, or in the decision to submit the manuscript for publication. |
| Copyright information: |
© 2017 Published by Elsevier Inc. on behalf of the Alzheimer's Association. This is an open access article under the CC BY-NC-NDlicense (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |