University of Oulu

Rosenberg, A., Ngandu, T., Rusanen, M., Antikainen, R., Bäckman, L., Havulinna, S., Hänninen, T., Laatikainen, T., Lehtisalo, J., Levälahti, E., Lindström, J., Paajanen, T., Peltonen, M., Soininen, H., Stigsdotter-Neely, A., Strandberg, T., Tuomilehto, J., Solomon, A., Kivipelto, M. (2018) Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial. 14 (3), 263-270. doi:10.1016/j.jalz.2017.09.006

Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics : the FINGER trial

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Author: Rosenberg, Anna1; Ngandu, Tiia2,3; Rusanen, Minna2,3,4;
Organizations: 1Institute of Clinical Medicine, Department of Neurology, University of Eastern Finland, Kuopio, Finland
2Department of Public Health Solutions, Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland
3Division of Clinical Geriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden
4Department of Neurology, North Karelia Central Hospital, Joensuu, Finland
5Center for Life Course Health Research/Geriatrics, University of Oulu, Oulu, Finland
6Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland
7Oulu City Hospital, Oulu, Finland
8Aging Research Center, Karolinska Institutet-Stockholm University, Stockholm, Sweden
9Aging, Disability and Functioning Unit, National Institute for Health and Welfare, Helsinki, Finland
10Department of Neurology, Kuopio University Hospital, Kuopio, Finland
11Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
12Joint municipal authority for North Karelia Social and Health services, Joensuu, Finland
13Department of Public Health, University of Helsinki, Helsinki, Finland
14Finnish Institute of Occupational Health, Helsinki, Finland
15Neurocenter, Neurology, Kuopio University Hospital, Kuopio, Finland
16Department of Psychology, Umeå University, Umeå, Sweden
17Department of Social and Psychological Sciences, Karlstad University, Karlstad, Sweden
18University of Helsinki, Helsinki University Hospital, Helsinki, Finland
19South Ostrobothnia Central Hospital, Seinäjoki, Finland
20Stockholms Sjukhem, Research & Development Unit, Stockholm, Sweden
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.4 MB)
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Language: English
Published: Elsevier, 2018
Publish Date: 2019-07-01


Introduction: The 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) multidomain lifestyle intervention trial (NCT01041989) demonstrated beneficial effects on cognition. We investigated whether sociodemographics, socioeconomic status, baseline cognition, or cardiovascular factors influenced intervention effects on cognition.

Methods: The FINGER recruited 1260 people from the general Finnish population (60–77 years, at risk for dementia). Participants were randomized 1:1 to multidomain intervention (diet, exercise, cognition, and vascular risk management) and regular health advice. Primary outcome was change in cognition (Neuropsychological Test Battery z-score). Prespecified analyses to investigate whether participants’ characteristics modified response to intervention were carried out using mixed-model repeated-measures analyses.

Results: Sociodemographics (sex, age, and education), socioeconomic status (income), cognition (Mini–Mental State Examination), cardiovascular factors (body mass index, blood pressure, cholesterol, fasting glucose, and overall cardiovascular risk), and cardiovascular comorbidity did not modify response to intervention (P-values for interaction > .05).

Conclusions: The FINGER intervention was beneficial regardless of participants’ characteristics and can thus be implemented in a large elderly population at increased risk for dementia.

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Series: Alzheimer's & dementia. The journal of the Alzheimer's Association
ISSN: 1552-5260
ISSN-E: 1552-5279
ISSN-L: 1552-5260
Volume: 14
Issue: 3
Pages: 263 - 270
DOI: 10.1016/j.jalz.2017.09.006
Type of Publication: A1 Journal article – refereed
Field of Science: 3124 Neurology and psychiatry
Funding: This work was supported by the Academy of Finland's Responding to Public Health Challenges Research Programme, project grants 259615, 278457, 287490, 294061, key project funding 305810; Joint Program of Neurodegenerative Disorders–prevention (MIND-AD) grant; La Carita Foundation; Alzheimer Association grant (HAT-10-173121); Juho Vainio Foundation, Finnish Medical Foundation; Novo Nordisk Foundation; Finnish Social Insurance Institution; Ministry of Education and Culture Research grant, and EVO/VTR grants of University Hospitals of Kuopio, Oulu and Turku, Seinäjoki Central Hospital and Oulu City Hospital; Swedish Research Council; Knut and Alice Wallenberg Foundation, Sweden; Center for Innovative Medicine (CIMED) at Karolinska Institutet, Sweden; Stiftelsen Stockholms sjukhem, Sweden; Konung Gustaf V:s och Drottning Victorias Frimurarstiftelse, Sweden; af Jochnick Foundation, Sweden; Alzheimer's Research & Prevention Foundation, USA; AXA Research Fund; University of Eastern Finland Doctoral School. Funding sources had no involvement in study design, collection, analysis or interpretation of data, writing the report, or in the decision to submit the manuscript for publication.
Copyright information: © 2017 Published by Elsevier Inc. on behalf of the Alzheimer's Association. This is an open access article under the CC BY-NC-NDlicense (