University of Oulu

Ylä-Herttuala, E., Saraste, A., Knuuti, J. et al. Curr Cardiovasc Imaging Rep (2019) 12: 11.

Molecular imaging to monitor left ventricular remodeling in heart failure

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Author: Ylä-Herttuala, Elias1; Saraste, Antti2,3; Knuuti, Juhani2,3;
Organizations: 1A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
2Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland
3Heart Center, Turku University Hospital, Turku, Finland
4Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland
5Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
6Heart Center, Kuopio University Hospital, Kuopio, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 5.1 MB)
Persistent link:
Language: English
Published: Springer Nature, 2019
Publish Date: 2019-07-01


Purpose of Review: Cardiovascular diseases are the leading cause of deaths worldwide. Many complex cellular and molecular pathways lead to myocardial remodeling after ischemic insults. Anatomy, function, and viability of the myocardium can be assessed by modern medical imaging techniques by both visualizing and quantifying damages. Novel imaging techniques aim for a precise and accurate visualization of the myocardium and for the detection of alternations at the molecular level.

Recent Findings: Magnetic resonance imaging assesses anatomy, function, and tissue characterization of the myocardium non-invasively with high spatial resolution, sensitivity, and specificity. Using hyperpolarized magnetic resonance imaging, molecular and metabolic conditions can be assessed non-invasively. Single photon-emission tomography and positron-emission tomography are the most sensitive techniques to detect biological processes in the myocardium. Cardiac perfusion, metabolism, and viability are the most common clinical targets. In addition, molecular-targeted imaging of biological processes involved in heart failure, such as myocardial innervation, inflammation, and extracellular matrix remodeling, is feasible.

Summary: Novel imaging techniques can provide a precise and accurate visualization of the myocardium and for the detection of alternations at molecular level.

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Series: Current cardiovascular imaging reports
ISSN: 1941-9066
ISSN-E: 1941-9074
ISSN-L: 1941-9066
Volume: 12
Issue: 4
Article number: 11
DOI: 10.1007/s12410-019-9487-3
Type of Publication: A2 Review article in a scientific journal
Field of Science: 3126 Surgery, anesthesiology, intensive care, radiology
Funding: This study has been supported by the Finnish Academy Center of Excellence, Instrumentarium Science Foundation, Finnish Foundation for Cardiovascular Research, and Finnish Heart Foundation. Open access funding provided by University of Eastern Finland (UEF) including Kuopio University Hospital.
Copyright information: © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.