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Molecular imaging to monitor left ventricular remodeling in heart failure |
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| Author: | Ylä-Herttuala, Elias1; Saraste, Antti2,3; Knuuti, Juhani2,3; |
| Organizations: |
1A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland 2Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland 3Heart Center, Turku University Hospital, Turku, Finland
4Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland
5Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland 6Heart Center, Kuopio University Hospital, Kuopio, Finland |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 5.1 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2019070122512 |
| Language: | English |
| Published: |
Springer Nature,
2019
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| Publish Date: | 2019-07-01 |
| Description: |
AbstractPurpose of Review: Cardiovascular diseases are the leading cause of deaths worldwide. Many complex cellular and molecular pathways lead to myocardial remodeling after ischemic insults. Anatomy, function, and viability of the myocardium can be assessed by modern medical imaging techniques by both visualizing and quantifying damages. Novel imaging techniques aim for a precise and accurate visualization of the myocardium and for the detection of alternations at the molecular level. Recent Findings: Magnetic resonance imaging assesses anatomy, function, and tissue characterization of the myocardium non-invasively with high spatial resolution, sensitivity, and specificity. Using hyperpolarized magnetic resonance imaging, molecular and metabolic conditions can be assessed non-invasively. Single photon-emission tomography and positron-emission tomography are the most sensitive techniques to detect biological processes in the myocardium. Cardiac perfusion, metabolism, and viability are the most common clinical targets. In addition, molecular-targeted imaging of biological processes involved in heart failure, such as myocardial innervation, inflammation, and extracellular matrix remodeling, is feasible. Summary: Novel imaging techniques can provide a precise and accurate visualization of the myocardium and for the detection of alternations at molecular level. see all
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| Series: |
Current cardiovascular imaging reports |
| ISSN: | 1941-9066 |
| ISSN-E: | 1941-9074 |
| ISSN-L: | 1941-9066 |
| Volume: | 12 |
| Issue: | 4 |
| Article number: | 11 |
| DOI: | 10.1007/s12410-019-9487-3 |
| OADOI: | https://oadoi.org/10.1007/s12410-019-9487-3 |
| Type of Publication: |
A2 Review article in a scientific journal |
| Field of Science: |
3126 Surgery, anesthesiology, intensive care, radiology |
| Subjects: | |
| Funding: |
This study has been supported by the Finnish Academy Center of Excellence, Instrumentarium Science Foundation, Finnish Foundation for Cardiovascular Research, and Finnish Heart Foundation. Open access funding provided by University of Eastern Finland (UEF) including Kuopio University Hospital. |
| Copyright information: |
© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
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https://creativecommons.org/licenses/by/4.0/ |