University of Oulu

Elena Toffol, Marius Lahti-Pulkkinen, Jari Lahti, Jari Lipsanen, Kati Heinonen, Anu-Katriina Pesonen, Esa Hämäläinen, Eero Kajantie, Hannele Laivuori, Pia M. Villa, Katri Räikkönen, Maternal depressive symptoms during and after pregnancy are associated with poorer sleep quantity and quality and sleep disorders in 3.5-year-old offspring, Sleep Medicine, Volume 56, 2019, Pages 201-210, ISSN 1389-9457, https://doi.org/10.1016/j.sleep.2018.10.042

Maternal depressive symptoms during and after pregnancy are associated with poorer sleep quantity and quality and sleep disorders in 3.5-year-old offspring

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Author: Toffol, Elena1,2; Lahti-Pulkkinen, Marius1,2,3; Lahti, Jari1,4;
Organizations: 1Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland
2National Institute for Health and Welfare, Helsinki, Finland
3University/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research, Edinburgh, UK
4Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, Finland
5Department of Clinical Chemistry, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
6Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
7PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
8Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
9Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland
10Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland
11Department of Obstetrics and Gynaecology, Tampere University Hospital, Tampere, Finland
12Department of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2019070222627
Language: English
Published: Elsevier, 2019
Publish Date: 2020-04-30
Description:

Abstract

Objective: Maternal depressive symptoms during pregnancy have been associated with poor offspring sleep. Yet, it remains unknown whether depressive symptoms throughout pregnancy are more harmful to the child than depressive symptoms only during certain time periods in pregnancy, whether associations are specific to pregnancy stage, whether maternal symptomatology after pregnancy mediates or adds to the prenatal effects, and whether any effects are specific to some child sleep characteristics.

Methods: A total of 2321 mothers from the Prediction and Prevention of Pre-eclampsia and Intrauterine Growth Restriction (PREDO) study completed the Center for Epidemiological Studies Depression Scale biweekly between gestational weeks + days 12 + 0/13 + 6 and 38 + 0/39 + 6. At child’s mean age of 3.5 (standard deviation = 0.7) years, mothers completed the Beck Depression Inventory−II and answered questions on child sleep quantity and quality using the Brief Infant Sleep Questionnaire (BISQ) and sleep disorders using the Sleep Disturbance Scale for Children.

Results: Maternal depressive symptoms showed high stability throughout pregnancy. Children of mothers with clinically significant symptomatology throughout pregnancy had shorter mother-rated sleep duration, longer sleep latency, higher odds for waking up two or more times during the night and for total and several specific sleep disorders. These associations were robust to covariates. However, maternal depressive symptoms at the child follow-up fully mediated the associations with sleep duration and awakenings, partially mediated those with sleep latency and disorders, and added to the effects on sleep disorders.

Conclusion: Maternal depressive symptoms throughout pregnancy are associated with mother-rated child sleep quantity, quality, and disorders. Maternal depressive symptoms at child follow-up mediate and add to the prenatal adverse effects on child sleep characteristics.

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Series: Sleep medicine
ISSN: 1389-9457
ISSN-E: 1878-5506
ISSN-L: 1389-9457
Volume: 56
Pages: 201 - 210
DOI: 10.1016/j.sleep.2018.10.042
OADOI: https://oadoi.org/10.1016/j.sleep.2018.10.042
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
Subjects:
Funding: The PREDO study is funded by the Academy of Finland, Era-Net Neuron, European Commission (RECAP H2020-SC1-2016-RTDaward 733280), EVO, University of Helsinki Research Funds; the Signe and Ane Gyllenberg Foundation, Emil Aaltonen Foundation,Jane and Aatos Erkko Foundation, Juho Vainio Foundation, Novo Nordisk Foundation, Päivikki and Sakari Sohlberg Foundation,Sigrid Juselius Foundation and Yrjö Jahnsson Foundation; the Finnish Medical Foundation.
Copyright information: © 2018 Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.
  https://creativecommons.org/licenses/by-nc-nd/4.0/