University of Oulu

Jaakko M. Piitulainen, Jussi P. Posti, Pekka K. Vallittu, Kalle M. Aitasalo, Willy Serlo, A Large Calvarial Bone Defect in a Child: Osseointegration of an Implant, World Neurosurgery, Volume 124, 2019, Pages 282-286, ISSN 1878-8750,

A large calvarial bone defect in a child : osseointegration of an implant

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Author: Piitulainen, Jaakko M.1,2; Posti, Jussi P.3,4,2; Vallittu, Pekka K.2,5;
Organizations: 1Department of Otorhinolaryngology–Head and Neck Surgery, Division of Surgery and Cancer Diseases, Turku University Hospital, University of Turku, Turku, Finland
2Department of Biomaterials Science and Turku Clinical Biomaterials Centre, Institute of Dentistry, University of Turku, Turku, Finland
3Department of Neurosurgery, Division of Clinical Neurosciences, Turku University Hospital, University of Turku, Turku, Finland
4Turku Brain Injury Centre, Turku University Hospital, University of Turku, Turku, Finland
5City of Turku Welfare Division, Turku, Finland
6Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland
7Medical Research Center Oulu and PEDEGO Research Unit, University of Oulu, Oulu, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 3.6 MB)
Persistent link:
Language: English
Published: Elsevier, 2019
Publish Date: 2020-04-30


Background: This original report describes the outcome of a cranioplasty at long-term follow-up. A large calvarial bone defect of a child was reconstructed with a bioactive and biostable nonmetallic implant.

Case Description: In a child with infantile fibrosarcoma of occipital bone, the malignancy was removed at 2.5 years of age, and the defect site was reconstructed with an onlay glass fiber-reinforced composite–bioactive glass implant. The follow-up examination at 5 years 7 months showed no signs of tumor recurrence. During the follow-up period, the contour of the reconstructed area followed skull anatomic development. Computed tomography demonstrated considerably large areas (approximately 70% of the total area) of bone ongrowth to the peridural surface of the implant.

Conclusions: In the future, a synthetic cranioplasty material that is able to integrate with cranial bone may be considered superior to cryopreserved bone grafts in younger age groups.

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Series: World neurosurgery
ISSN: 1878-8750
ISSN-E: 1878-8769
ISSN-L: 1878-8750
Volume: 124
Pages: 282 - 286
DOI: 10.1016/j.wneu.2019.01.028
Type of Publication: A1 Journal article – refereed
Field of Science: 3126 Surgery, anesthesiology, intensive care, radiology
3123 Gynaecology and paediatrics
Funding: J.P. Posti receives funding support from the Government’s Special Financial Transfer for academic research in health sciences (Finland), Emil Aaltonen Foundation, and Finnish Brain Foundation. J.M. Piitulainen receives funding support from the Finnish Association of Otorhinolaryngology and Head and Neck Surgery.
Copyright information: © 2019 Elsevier Inc. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license