University of Oulu

R. Kontio, J. Hagström, P. Lindholm, T. Böhling, M. Sampo, K. Mesimäki, K. Saarilahti, P. Koivunen, A.A. Mäkitie, Craniomaxillofacial osteosarcoma — The role of surgical margins, Journal of Cranio-Maxillofacial Surgery, Volume 47, Issue 6, 2019, Pages 922-925, ISSN 1010-5182, https://doi.org/10.1016/j.jcms.2019.03.020

Craniomaxillofacial osteosarcoma : the role of surgical margins

Saved in:
Author: Kontio, R.1; Hagström, J.2; Lindholm, P.3;
Organizations: 1Department of Oral and Maxillofacial Surgery — Head and Neck Surgery, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland
2Department of Pathology — Head and Neck Surgery, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland
3Department of Oncology, Turku University Hospital, Turku, Finland
4Department of Oncology — Head and Neck Surgery, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland
5Department of Otorhinolaryngology — Head and Neck Surgery, Oulu University Hospital, Oulu, Finland
6Department of Otorhinolaryngology — Head and Neck Surgery, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland
7Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
8Research Programme in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2019070322657
Language: English
Published: Elsevier, 2019
Publish Date: 2020-06-30
Description:

Abstract

Background: Osteosarcomas (OS) in the craniomaxillofacial (CMF) region are typically diagnosed at later age than long-bone OS, but they are reported to have better 5-year survival. Curative treatment warrants wide surgical resection, which is often not possible in the CMF region. The purpose of this article is to present a nationwide series of CMF in Finland to discuss the role of surgery.

Patients and methods: All 21 CMF OS patients managed in Finland from 1992 to 2009 were included. The mean age was 40 years (range 15–72). Data on patient and tumor characteristics, treatment modalities, and survival were recorded. All patients had a minimum follow-up of 5 years or until death.

Results: OS was evenly represented in the mandible and maxillary bones, which together constituted 76% of all sites. Surgery with curative intent was carried out in 20 patients. Clear margins were achieved in only five cases. Eight (40%) of these 20 patients died due to OS, and their average survival time was 1.3 years. Seven (35%) out of the 20 patients received radiotherapy due to close/intralesional surgical margins, and four of them did not develop recurrences during the follow-up.

Conclusions: The results suggest that postoperative radiotherapy may alter the prognosis in CMF OS, particularly in cases with close or intralesional margins. This may increase the survival rates achieved by prompt action in performing radical surgery.

see all

Series: Journal of cranio-maxillo-facial surgery
ISSN: 1010-5182
ISSN-E: 1878-4119
ISSN-L: 1010-5182
Volume: 47
Issue: 6
Pages: 922 - 925
DOI: 10.1016/j.jcms.2019.03.020
OADOI: https://oadoi.org/10.1016/j.jcms.2019.03.020
Type of Publication: A1 Journal article – refereed
Field of Science: 3125 Otorhinolaryngology, ophthalmology
3122 Cancers
3126 Surgery, anesthesiology, intensive care, radiology
Subjects:
Funding: This study was supported by the Helsinki University Hospital Research Fund.
Copyright information: ©2019 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.
  https://creativecommons.org/licenses/by-nc-nd/4.0/