University of Oulu

Jaana Karhu, Tero Ilmari Ala-Kokko, Tytti Vuorinen, Pasi Ohtonen, Ilkka Julkunen, Hannu Tapani Syrjälä, Interleukin-5, interleukin-6, interferon induced protein-10, procalcitonin and C-reactive protein among mechanically ventilated severe community-acquired viral and bacterial pneumonia patients, Cytokine, Volume 113, 2019, Pages 272-276, ISSN 1043-4666, https://doi.org/10.10/j.cyto.2018.07.019

Interleukin-5, interleukin-6, interferon induced protein-10, procalcitonin and C-reactive protein among mechanically ventilated severe community-acquired viral and bacterial pneumonia patients

Saved in:
Author: Karhu, Jaana1,2; Ala-Kokko, Tero1,2; Vuorinen, Tytti3;
Organizations: 1Department of Anaesthesiology, Division of Intensive Care, Oulu University Hospital, P.O. Box 21, FI-90029 OUH, Finland
2Medical Research Center Oulu Research Group of Surgery, Anaesthesiology and Intensive Care, University of Oulu, Finland
3Institute of Biomedicine/Virology, University of Turku, Kiinamyllynkatu 10 C 7, FI-20520 Turku, Finland
4Departments of Anaesthesiology and Surgery, Oulu University Hospital, P.O. Box 21, FI-90029 OUH, Finland
5Department of Infection Control, Oulu University Hospital, P.O. Box 21, FI-90029 OUH, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.8 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2019070322663
Language: English
Published: Elsevier, 2019
Publish Date: 2019-07-03
Description:

Abstract

Background: The serum cytokine levels among 45 mechanically ventilated, intensive care unit (ICU)-treated severe community-acquired pneumonia (SCAP) patients with known microbial etiology in three different etiology groups were assessed.

Methods: Blood samples for C-reactive protein (CRP), procalcitonin (PCT), interleukin (IL)-5, IL-6, IL-10, human interferon gamma induced protein (IP)-10, and TNF-α (tumor necrosis factor alpha) were collected at time points 0, 12, 24, 48, 72 and 96 h after study inclusion.

Results: There were 21 (43%) pure bacterial infections (bacterial group, BG), 5 (10%) pure viral infections (viral group, VG), and 19 (39%) mixed bacterial-viral infections (mixed group, MG) among 45 mechanically ventilated SCAP patients. CRP and PCT levels were significantly higher in the MG and values decreased with time in all groups. PCT differed also in time and group analysis (P = 0.001), the highest being in the MG. IL-5 levels were significantly higher in the VG compared to others (Ptime = 0.001, Pgroup = 0.051 and Ptimexgroup = 0.016). IL-6 and IP-10 levels decreased over time (Ptime = 0.003 and Ptime = 0.021), but there were no differences between groups.

Conclusions: SCAP patients with viral etiology have higher IL-5 levels. Patients with mixed viral and bacterial group have higher PCT compared to other etiologies.

see all

Series: Cytokine
ISSN: 1043-4666
ISSN-E: 1096-0023
ISSN-L: 1043-4666
Volume: 113
Pages: 272 - 276
DOI: 10.1016/j.cyto.2018.07.019
OADOI: https://oadoi.org/10.1016/j.cyto.2018.07.019
Type of Publication: A1 Journal article – refereed
Field of Science: 3141 Health care science
Subjects:
Funding: This work was supported by the Finnish State Funding for Health Research.
Copyright information: © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
  https://creativecommons.org/licenses/by-nc-nd/3.0/