Tiina Taka-Eilola (nèe Riekki), Juha Veijola, Graham K. Murray, Jari Koskela, Pirjo Mäki, Severe mood disorders and schizophrenia in the adult offspring of antenatally depressed mothers in the Northern Finland 1966 Birth Cohort: Relationship to parental severe mental disorder, Journal of Affective Disorders, Volume 249, 2019, Pages 63-72, ISSN 0165-0327, https://doi.org/10.1016/j.jad.2019.02.011
Severe mood disorders and schizophrenia in the adult offspring of antenatally depressed mothers in the Northern Finland 1966 Birth Cohort : relationship to parental severe mental disorder
|Author:||Taka-Eilola (nèe Riekki), Tiina1; Veijola, Juha1,2,3; Murray, Graham K.4;|
1Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, P.O. Box 5000, FIN-90014 Oulu, Finland
2Department of Psychiatry, Oulu University Hospital, Oulu, Finland
3Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
4Department of Psychiatry, University of Cambridge, 18b Trumpington Road, Cambridge CB2 8AH, United Kingdom
5Department of Psychiatry, Länsi-Pohja Healthcare District; Department of Psychiatry, the Middle Ostrobothnia Central Hospital, Soite; Mental Health Services, Joint Municipal Authority of Wellbeing in Raahe District; Mental Health Services and Basic Health Care District of Kallio; and Department of Psychiatry, Kainuu Central Hospital, Kainuu Social and Healthcare District, Finland
|Online Access:||PDF Full Text (PDF, 1.1 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2019070422762
|Publish Date:|| 2020-04-15
Background: Maternal antenatal depression may alter offspring neurodevelopment, but long follow-up studies are lacking. We studied the risks for mood disorders and schizophrenia in adult offspring of antenatally depressed mothers, taking account parental severe mental disorders.
Methods: In the general population-based Northern Finland 1966 Birth Cohort with 12,058 children, 13.9% of the mothers reported themselves depressed at mid-gestation. The offspring were followed 43 years. Severe mood disorders and schizophrenia in the offspring and severe mental disorders in the parents were detected using the Care Register for Healthcare. Maternal smoking during pregnancy, perinatal complications, fathers’ social class, family type at birth, and grand multiparity were considered as confounding variables.
Results: The offspring of antenatally depressed mothers had an elevated risk for depression (adjusted OR 1.5; 95% CI 1.03–2.2), compared to cohort members without maternal antenatal depressed mood. The offspring with maternal antenatal depressed mood and parental severe mental disorder had markedly elevated risks for depression (3.3; 1.8–6.2), and schizophrenia (3.9; 2.0–7.5), compared to the offspring without one or both of these risk factors.
Limitations: Maternal antenatal depressed mood was determined by one question and did not necessarily signify a clinical condition. Data on maternal postnatal mood was not available.
Conclusion: The offspring with maternal antenatal depressed mood and parental severe mental disorder had high risk for depression and schizophrenia. Early interventions in parental severe mental disorder might present an opportunity for decreasing the risk for mood disorders and schizophrenia in the offspring.
Journal of affective disorders
|Pages:||63 - 72|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3124 Neurology and psychiatry
The work was supported by grants from the Paulo Foundation (author TTE), Jalmari and Rauha Ahokas Foundation, Academy of Finland (#124257, #212818, #214273) (author JV), the Sigrid Juselius Foundation (author JV), the Signe and Ane Gyllenberg Foundation, Finland (author PM). The funding sources were not involved in study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the article for publication.
|Academy of Finland Grant Number:||
124257 (Academy of Finland Funding decision)
212818 (Academy of Finland Funding decision)
214273 (Academy of Finland Funding decision)
© 2019 Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.