University of Oulu

Myllymäki, V, Saxlin, T, Knuuttila, M, et al. Association between periodontal condition and the development of type 2 diabetes mellitus—Results from a 15‐year follow‐up study. J Clin Periodontol. 2018; 45: 1276– 1286. https://doi.org/10.1111/jcpe.13005

Association between periodontal condition and the development of type 2 diabetes mellitus : results from a 15-year follow-up study

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Author: Myllymäki, Ville1; Saxlin, Tuomas1,2,3; Knuuttila, Matti4,5;
Organizations: 1Institute of Dentistry, University of Eastern Finland, Kuopio, Finland
2Department of Oral and Maxillofacial Diseases, Kuopio University Hospital, Kuopio, Finland
3Research Unit of Oral Health Sciences, University of Oulu, Oulu, Finland
4Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
5Department of Oral and Maxillofacial Surgery, Oulu University Hospital, Oulu, Finland
6Center for Life Course Health Research, University of Oulu, Oulu, Finland
7Unit of Primary Health Care, Oulu University Hospital, Oulu, Finland
8Teaching Health Centre, City of Oulu, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2019070422793
Language: English
Published: John Wiley & Sons, 2018
Publish Date: 2019-11-30
Description:

Abstract

Aim: To study whether periodontal condition is associated with the development of type 2 diabetes mellitus (T2DM).

Materials and Methods: A population‐based follow‐up study was conducted among persons born in 1935 and living in the city of Oulu, Finland (n = 395). The baseline examinations were done during 1990–1992, and the follow‐up examinations were done during 2007–2008. The data were gathered by questionnaires, laboratory tests and clinical measurements. Poisson regression models were used in the data analyses.

Results: The adjusted rate ratios (RR) with 95% confidence intervals (95% CI) for the incident T2DM among subjects with 4–5 mm deep periodontal pockets (n = 98), among subjects with 6 mm deep or deeper periodontal pockets (n = 91), and among edentulous subjects (n = 118) were 1.32 (95% CI: 0.69–2.53), 1.56 (95% CI: 0.84–2.92) and 1.00 (95% CI: 0.53–1.89), respectively, compared to dentate subjects without deepened (4 mm deep or deeper) periodontal pockets (n = 88). The adjusted RR per site (the number of sites with deepened periodontal pockets as a continuous variable) was 1.02 (95% CI: 1.00–1.04).

Conclusions: Poor periodontal condition may be a predictor of the development of T2DM. However, the causality between periodontal condition and the development of T2DM remains uncertain.

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Series: Journal of clinical periodontology
ISSN: 0303-6979
ISSN-E: 1600-051X
ISSN-L: 0303-6979
Volume: 45
Issue: 11
Pages: 1276 - 1286
DOI: 10.1111/jcpe.13005
OADOI: https://oadoi.org/10.1111/jcpe.13005
Type of Publication: A1 Journal article – refereed
Field of Science: 313 Dentistry
Subjects:
Copyright information: © 2018 John Wiley & Sons A/S. This is the peer reviewed version of the following article: Myllymäki, V, Saxlin, T, Knuuttila, M, et al. Association between periodontal condition and the development of type 2 diabetes mellitus—Results from a 15‐year follow‐up study. J Clin Periodontol. 2018; 45: 1276– 1286. https://doi.org/10.1111/jcpe.13005, which has been published in final form at https://doi.org/10.1111/jcpe.13005. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.