University of Oulu

Cuthbertson, DJ, Brown, E, Koskinen, J, et al. Longitudinal analysis of risk of non‐alcoholic fatty liver disease in adulthood. Liver Int. 2019; 39: 1147– 1154. https://doi.org/10.1111/liv.13993

Longitudinal analysis of risk of non-alcoholic fatty liver disease in adulthood

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Author: Cuthbertson, Daniel J.1; Brown, Emily1; Koskinen, Juha2,3;
Organizations: 1Obesity and Endocrinology Research Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK
2Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
3Heart Center, Kymenlaakson keskussairaala, Kotka, Finland
4Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia
5Department of Pediatrics, University of Tampere and Tampere University Hospital, Tampere, Finland
6Murdoch Children’s Research Institute, Melbourne, Victoria, Australia
7The Royal Children’s Hospital and University of Melbourne, Melbourne, Victoria, Australia
8Department of Pediatrics, PEDEGO Research Unit and Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland
9Department of Pediatric Cardiology, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
10Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland
11Department of Medicine, University of Turku, Turku, Finland
12Division of Medicine, Turku University Hospital, Turku, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2019070522811
Language: English
Published: John Wiley & Sons, 2019
Publish Date: 2020-06-30
Description:

Abstract

Background & Aims: We aimed to determine how childhood body mass index and metabolic health, along with the change in body mass index between childhood and adulthood, determine the risk of adult non‐alcoholic fatty liver disease.

Methods: Data from 2020 participants aged 3‐18 years at baseline, followed up 31 years later, were examined to assess the utility of four childhood metabolic phenotypes (Metabolic Groups I: normal body mass index, no metabolic disturbances; II: normal body mass index, one or more metabolic disturbances; III: overweight/obese, no metabolic disturbances; IV: overweight/obese, one or more metabolic disturbances) and four life‐course adiposity phenotypes (Adiposity Group 1: normal child and adult body mass index; 2, high child, normal adult body mass index; 3, normal child body mass index, high adult body mass index; 4, high child and adult body mass index) in predicting adult non‐alcoholic fatty liver disease.

Results: The risk for adult non‐alcoholic fatty liver disease was similar across all four groups after adjustment for age, sex, lifestyle factors and adult body mass index. Risk of adult non‐alcoholic fatty liver disease was not increased among individuals overweight/obese in childhood but non‐obese in adulthood. In contrast, overweight or obese adults, irrespective of their youth body mass index status, had ~eight‐fold to 10‐fold increased risk (P < 0.001).

Conclusions: Childhood overweight/obesity, not metabolic health, is associated with increased risk for adult non‐alcoholic fatty liver disease. However, the increased risk associated with childhood overweight/obesity can be largely removed by obtaining a normal body mass index by adulthood.

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Series: Liver international
ISSN: 1478-3223
ISSN-E: 1478-3231
ISSN-L: 1478-3223
Volume: 39
Issue: 6
Pages: 1147 - 1154
DOI: 10.1111/liv.13993
OADOI: https://oadoi.org/10.1111/liv.13993
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Subjects:
Funding: The Young Finns Study has been supported by Academy of Finland grants 126925, 121584, 124282, 129378 (Salve), 117797 (Gendi) and 41071 (Skidi); the Social Insurance Institution of Finland; Kuopio, Tampere and Turku University Hospital Medical Funds (grants 9M048 and 9N035); the Juho Vainio Foundation; the Paavo Nurmi Foundation; the Finnish Foundation for Cardiovascular Research; the Finnish Cultural Foundation; the Tampere Tuberculosis Foundation; and the Emil Aaltonen Foundation. This work was also funded by the National Health and Medical Research Council (grant APP1098369). C.G.M is supported by a National Heart Foundation of Australia Future Leader Fellowship (100849). J.K. was supported by Turku University Foundation, Emil Aaltonen Foundation and Urmas Pekkala Foundation.
Copyright information: © 2018 John Wiley & Sons A/S. This is the peer reviewed version of the following article: Cuthbertson, DJ, Brown, E, Koskinen, J, et al. Longitudinal analysis of risk of non‐alcoholic fatty liver disease in adulthood. Liver Int. 2019; 39: 1147– 1154. https://doi.org/10.1111/liv.13993 , which has been published in final form at https://doi.org/10.1111/liv.13993. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.