University of Oulu

Jenni Lehtisalo, Esko Levälahti, Jaana Lindström, Tuomo Hänninen, Teemu Paajanen, Markku Peltonen, Riitta Antikainen, Tiina Laatikainen, Timo Strandberg, Hilkka Soininen, Jaakko Tuomilehto, Miia Kivipelto, Tiia Ngandu, Dietary changes and cognition over 2 years within a multidomain intervention trial—The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), Alzheimer’s & Dementia, Volume 15, Issue 3, 2019, Pages 410-417, ISSN 1552-5260,

Dietary changes and cognition over 2 years within a multidomain intervention trial : the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)

Saved in:
Author: Lehtisalo, Jenni1,2; Levälahti, Esko1; Lindström, Jaana1;
Organizations: 1Department of Public Health Solutions, Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland
2Department of Public Health, University of Helsinki, Helsinki, Finland
3Department of Neurology, Kuopio University Hospital, Kuopio, Finland
4Research and Service Centre for Occupational Health, Finnish Institute of Occupational Health, Helsinki, Finland
5Center for Life Course Health Research, University of Oulu, Oulu, Finland
6Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland
7Oulu City Hospital, Oulu, Finland
8Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
9Joint Municipal Authority for North Karelia Social and Health Services, Joensuu, Finland
10University of Helsinki, Clinicum, and Helsinki University Hospital, Helsinki, Finland
11Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
12South Ostrobothnia Central Hospital, Seinäjoki, Finland
13Department of Clinical Neurosciences and Preventive Medicine, Danube-University Krems, Krems, Austria
14Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia
15Dasman Diabetes Institute, Kuwait City, Kuwait
16Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Huddinge, Sweden
17Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden
18Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, London, United Kingdom
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.3 MB)
Persistent link:
Language: English
Published: Elsevier, 2019
Publish Date: 2019-07-08


Introduction: Association between healthy diet and better cognition is well established, but evidence is limited to evaluate the effect of dietary changes adopted in older age.

Methods: We investigated the role of dietary changes in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) with 1260 at-risk participants (60–77 years) who were randomized to intensive multidomain intervention (including dietary counseling) or regular health advice for 2 years. Parallel process latent growth curves of adherence to dietary recommendations and cognitive performance were analyzed.

Results: Adherence to healthy diet at baseline predicted improvement in global cognition, regardless of intervention allocation (P = .003). Dietary improvement was associated with beneficial changes in executive function, especially in the intervention group (P = .008; P = .051 for groups combined).

Discussion: Dietary changes initiated during the intervention were related to changes in executive function in 2 years. Long-term diet appeared more influential for global cognition.

see all

Series: Alzheimer's & dementia. The journal of the Alzheimer's Association
ISSN: 1552-5260
ISSN-E: 1552-5279
ISSN-L: 1552-5260
Volume: 15
Issue: 3
Pages: 410 - 417
DOI: 10.1016/j.jalz.2018.10.001
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Funding: The FINGER trial was supported by the Academy of Finland (Responding to Public Health Challenges Research Programme SALVE; and grant numbers 129395, 129397, 129459, 129421, 129416, 129511, 129401, 259615, 278457); the Finnish Medical Foundation; La Carita Foundation; Alzheimer's Association (HAT-10-173121); Juho Vainio Foundation; Novo Nordisk Foundation; Finnish Social Insurance Foundation; Ministry of Education and Culture Research Grant; EVO/VTR grants of University Hospitals of Kuopio, Oulu and Turku, Seinäjoki Central Hospital and Oulu City Hospital for FINGER project; Swedish Research Council; Alzheimer's Research & Prevention Foundation, USA; AXA Research Found; the Sheikha Salama Bint Hamdan Al Nahyan Foundation; Knut and Alice Wallenberg Foundation, Sweden; Center for Innovative Medicine (CIMED) at Karolinska Institutet, Sweden; Stiftelsen Stockholms Sjukhem, Sweden, Konung Gustaf V:s och Drottning Victorias Frimurarstiftelse, Sweden; and Alexander von Humboldt Research award, and a donation from the af Jochnick Foundation. Funders had no role in the design, analysis, or writing of this article.
Academy of Finland Grant Number: 129416
Detailed Information: 129416 (Academy of Finland Funding decision)
Copyright information: © 2018 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY-NC-ND license (