|
|
Dietary changes and cognition over 2 years within a multidomain intervention trial : the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) |
|---|---|
| Author: | Lehtisalo, Jenni1,2; Levälahti, Esko1; Lindström, Jaana1; |
| Organizations: |
1Department of Public Health Solutions, Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland 2Department of Public Health, University of Helsinki, Helsinki, Finland 3Department of Neurology, Kuopio University Hospital, Kuopio, Finland
4Research and Service Centre for Occupational Health, Finnish Institute of Occupational Health, Helsinki, Finland
5Center for Life Course Health Research, University of Oulu, Oulu, Finland 6Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland 7Oulu City Hospital, Oulu, Finland 8Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland 9Joint Municipal Authority for North Karelia Social and Health Services, Joensuu, Finland 10University of Helsinki, Clinicum, and Helsinki University Hospital, Helsinki, Finland 11Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland 12South Ostrobothnia Central Hospital, Seinäjoki, Finland 13Department of Clinical Neurosciences and Preventive Medicine, Danube-University Krems, Krems, Austria 14Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia 15Dasman Diabetes Institute, Kuwait City, Kuwait 16Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Huddinge, Sweden 17Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden 18Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, London, United Kingdom |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.3 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2019070822886 |
| Language: | English |
| Published: |
Elsevier,
2019
|
| Publish Date: | 2019-07-08 |
| Description: |
AbstractIntroduction: Association between healthy diet and better cognition is well established, but evidence is limited to evaluate the effect of dietary changes adopted in older age. Methods: We investigated the role of dietary changes in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) with 1260 at-risk participants (60–77 years) who were randomized to intensive multidomain intervention (including dietary counseling) or regular health advice for 2 years. Parallel process latent growth curves of adherence to dietary recommendations and cognitive performance were analyzed. Results: Adherence to healthy diet at baseline predicted improvement in global cognition, regardless of intervention allocation (P = .003). Dietary improvement was associated with beneficial changes in executive function, especially in the intervention group (P = .008; P = .051 for groups combined). Discussion: Dietary changes initiated during the intervention were related to changes in executive function in 2 years. Long-term diet appeared more influential for global cognition. see all
|
| Series: |
Alzheimer's & dementia. The journal of the Alzheimer's Association |
| ISSN: | 1552-5260 |
| ISSN-E: | 1552-5279 |
| ISSN-L: | 1552-5260 |
| Volume: | 15 |
| Issue: | 3 |
| Pages: | 410 - 417 |
| DOI: | 10.1016/j.jalz.2018.10.001 |
| OADOI: | https://oadoi.org/10.1016/j.jalz.2018.10.001 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3121 General medicine, internal medicine and other clinical medicine |
| Subjects: | |
| Funding: |
The FINGER trial was supported by the Academy of Finland (Responding to Public Health Challenges Research Programme SALVE; and grant numbers 129395, 129397, 129459, 129421, 129416, 129511, 129401, 259615, 278457); the Finnish Medical Foundation; La Carita Foundation; Alzheimer's Association (HAT-10-173121); Juho Vainio Foundation; Novo Nordisk Foundation; Finnish Social Insurance Foundation; Ministry of Education and Culture Research Grant; EVO/VTR grants of University Hospitals of Kuopio, Oulu and Turku, Seinäjoki Central Hospital and Oulu City Hospital for FINGER project; Swedish Research Council; Alzheimer's Research & Prevention Foundation, USA; AXA Research Found; the Sheikha Salama Bint Hamdan Al Nahyan Foundation; Knut and Alice Wallenberg Foundation, Sweden; Center for Innovative Medicine (CIMED) at Karolinska Institutet, Sweden; Stiftelsen Stockholms Sjukhem, Sweden, Konung Gustaf V:s och Drottning Victorias Frimurarstiftelse, Sweden; and Alexander von Humboldt Research award, and a donation from the af Jochnick Foundation. Funders had no role in the design, analysis, or writing of this article. |
| Academy of Finland Grant Number: |
129416 |
| Detailed Information: |
129416 (Academy of Finland Funding decision) |
| Copyright information: |
© 2018 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0) |
|
https://creativecommons.org/licenses/by-nc-nd/4.0/ |